The calmodulin antagonist W7 and 4 of its analogues were examined for their ability to inhibit human NK cell mediated cytotoxicity. With the exception of one of these compounds, which is extremely hydrophobic, there was a good correlation between the ability of drugs to inhibit human NK antitumour cytotoxicity and calmodulin-dependent phosphodiesterase activity in vitro. The most potent of the ...

Enzymatic ribosylation of fluorescent 8-azapurine derivatives, like 8-azaguanine and 2,6-diamino-8-azapurine, with purine-nucleoside phosphorylase (PNP) as a catalyst, leads to N9, N8, and N7-ribosides. The final proportion of the products may be modulated by point mutations in the enzyme active site. As an example, ribosylation of the latter substrate by wild-type calf PNP gives N7- and N8-rib...

Hanan Selman Hessan and Ahmed Mohammed Abbas 563 Abstract Immune status was examined after tonsillectomy operations in 30 children with recurrent acute tonsillitis, their ages ranged between 3-10 years, were clinically diagnosed by ENT surgeon at AlHilla General Teaching Hospital and 10 apparently healthy children were included as a control in the study which lasted from February to May 2011 .I...

Ethylene oxide (EO) is widely used in the chemical industry and is also formed in humans through the metabolic oxidation of ethylene, generated during physiologic processes. EO is classified as a human carcinogen and is a direct acting alkylating agent, primarily forming N7-(2-hydroxyethyl)guanine (N7-HEG). To conduct accurate human risk assessments, it is vital to ascertain the relative contri...

Many xenobiotics exert their toxic effects through interaction with DNA in the cells of the exposed organism. This interaction may lead to the formation DNA adducts. Some of these may give rise to mutations that initiate cell transformation and, ultimately, the formation of tumors. Sensitive methods for determining DNA adducts are indispensable for the study of chemical mutagenesis and carcinog...

The macro acidity constants valid for aqueous solutions of several adenine, guanine, and hypoxanthine derivatives are summarized. It is shown how the application of the corresponding constants, e.g., for 7,9-dimethyladenine, allows a quantification of the intrinsic acidic properties of the (N1)H0/+ and (N7)H+ sites via micro acidity constants, and how to use this information for the calculation...

Ethylene oxide (EO) is widely used in the chemical industry and is also formed in humans through the metabolic oxidation of ethylene, generated during physiologic processes. EO is classified as a human carcinogen and is a direct acting alkylating agent, primarily forming N7-(2-hydroxyethyl)guanine (N7-HEG). To conduct accurate human risk assessments, it is vital to ascertain the relative contri...

هديکچ ت یحارط یارب ديدج شور کي هلاقم نيا رد تيوق ارا یطخ زاف اب هدرتسگ هدننک ئ يم ه دوش . شور نيا تيوقت و لاسروسنارت لاتيجيد رتليف یژولوپوت نيب تهابش یانبم رب يم هدرتسگ هدننک دشاب . نيا یانبم رب رواجم هقبط ود نيب ريخات رادقم و هدننک تيوقت زا هقبط ره نيگ یژولوپوت رتليف هيروف طسب زا هدافتسا اب Raise Cosine يم نييعت یروط یسناکرف هلصاف رد هک دوش 0-40 GHz تيوقت یطخ زاف هصخشم یاراد هدننک دشاب ه...

* لوئســ م هدنســ يون : ،نارــ هت ناــ بايخ ،رســ نارهت ناــ بايخ رسنارهت ميرك هاگنامرد ،رفولين راولب ،بيغتسد نفلت : 44506655 email: [email protected] فده و هنيمز : اب نمزم سامت تارثا لاّلح اه ناسنا تملاس رب يلآ ي هـتفرگ رارـق يسررب دروم فلتخم تاعلاطم رد اه اب سامت نيب هجوت لباق طابترا رگناشن هك لاّلح اه تيرفنولورمولگ و تسا هدوب اه . ركراـم يسررب هعلاطم نيا زا فده يويلك تيمس هب ساسح يرا...

Using specific features of the magnetic equilibrium in the W7-X stellarator, ECRH scenarios with X2 and X3 modes are discussed. The aim is to explore the possibility of selective heating of the different classes of electrons, passing and trapped, by different RF beams with different frequencies, which can be launched from ports located in different crosssections of the device. Perspectives for ...