Presently, the understanding of bacterial enteric diseases in the community and their virulence factors relies almost exclusively on clinical disease reporting and examination of clinical pathogen isolates. This study aimed to investigate the feasibility of an alternative approach that monitors potential enteropathogenic Escherichia coli (EPEC) and enterohemorrhagic E. coli (EHEC) prevalence an...

Experimental autoimmune encephalomyelitis (EAE) serves as the prototypic model for T cell–mediated autoim-munity. EAE has striking similarities with the human disease acute disseminated encephalomyelitis, a complication seen with vaccination and after certain viral infections. EAE has been used as a model to help understand the pathogenesis of multiple sclerosis (MS) and to help identify potent...

Both T cells and B cells are implicated in the pathology of multiple sclerosis (MS), but how these cells cooperate to drive disease remains unclear. Recent studies using experimental autoimmune encephalomyelitis (EAE) demonstrated that the TH17 pathway is correlated with increased numbers of ectopic B-cell follicles in the central nervous system (CNS). As follicular T helper (TFH) cells are reg...

Multiple sclerosis (MS) and its animal model experimental autoimmune encephalomyelitis (EAE) are inflammatory demyelinating and neurodegenerative diseases in the central nervous system (CNS). It is believed that MS and EAE are initiated by autoreactive T lymphocytes that recognize myelin antigens; however, the mechanisms responsible for neurodegeneration in these diseases remain elusive. Data i...

Experimental autoimmune encephalomyelitis (EAE) is the most widely accepted in vivo animal model of Multiple sclerosis (MS). EAE model are most suitable for analysis of immunogenetic elements (major histocompatibility complex) and for the study of histological features (inflammation, demyelination and degeneration) of the disease for screening of new treatments for MS. Some approved medications...

Several matrix metalloproteinase (MMP) members contribute to pathology in multiple sclerosis and experimental autoimmune encephalomyelitis (EAE). As the role of MMP-12 in EAE has been understudied, we examined its expression in EAE and in vitro. MMP-12 transcripts increased with EAE, and protein was localized to a subset of macrophages/microglia. The temporal expression of MMP-12 largely corres...

Objective Evaluate chimeric antigen receptor (CAR)-T cell mediated B depletion in experimental autoimmune encephalomyelitis (EAE). Background CAR-T cells are autologous T expressing a non-MHC target specific receptor. We tested whether anti-CD19 cells, which more thoroughly deplete human populations than monoclonal antibodies (mAbs), recapitulated the beneficial effects of EAE. Design/Methods A...

to understand the mechanism of multiple sclerosis (ms), an autoimmune demyelinating disease, the researchers developed an experimental animal model for ms, which is called eae (experimental allergic encephalomyelitis). there are several methods for inducing this animal model. in this research the active eae, which is developed by injecting bovine myelin antigens into genetically susceptible ani...

Introduction: Experimental autoimmune (allergic) encephalomyelitis (EAE) induced by intradermal injection of ho­mogenate the brain, spinal cord and peripheral nerve with Freund’s stimulator, refers to a true disease nervous system.
 Materials methods: studies were conducted on white nonlinear rats. To induce experimental aller­gic (EAE), homologous brain homogenates was used, which leads a...