In the present study, we used a mouse model of chronic intermittent ethanol (CIE) exposure to examine how CIE alters the plasticity of the medial prefrontal cortex (mPFC). In acute slices obtained either immediately or 1-week after the last episode of alcohol exposure, voltage-clamp recording of excitatory post-synaptic currents (EPSCs) in mPFC layer V pyramidal neurons revealed that CIE exposu...

Withdrawal anxiety is a significant factor contributing to continued alcohol abuse in alcoholics. This anxiety is long lasting, can manifest well after the overt physical symptoms of withdrawal, and is frequently associated with relapse in recovering alcoholics. The neurobiological mechanisms governing these withdrawal-associated increases in anxiety are currently unknown. The basolateral amygd...

Withdrawal (WD) anxiety is a significant factor contributing to continued alcohol abuse in alcoholics. This anxiety is extensive, long-lasting, and develops well after the obvious physical symptoms of acute WD. The neurobiological mechanisms underlying this prolonged WD-induced anxiety are not well understood. The basolateral amygdala (BLA) is a major emotional center in the brain and regulates...

Drug addictions including alcoholism are characterized by degradation of executive control over behavior and increased compulsive drug seeking. These profound behavioral changes are hypothesized to involve a shift in the regulation of behavior from prefrontal cortex to dorsal striatum (DLS). Studies in rodents have shown that ethanol disrupts cognitive processes mediated by the prefrontal corte...

[1] The carbonate saturation profile of the oceans shoaled markedly during a transient global warming event known as the Paleocene-Eocene thermal maximum (PETM) (circa 55 Ma). The rapid release of large quantities of carbon into the ocean-atmosphere system is believed to have triggered this intense episode of dissolution along with a negative carbon isotope excursion (CIE). The brevity (120–220...

BACKGROUND In the 1920s and 1930s, disability glare was a topic of great interest in the Commission Internationale de l'Eclairage (CIE). The Second World War prevented agreement being reached on a standard to quantify disability glare but the Stiles-Holladay formula was widely accepted as such. In 1983, CIE started a new effort to develop a CIE standard making use of research data published in ...

The CIE 1997 Interim Color Appearance Model (Simple Version), abbreviated CIECAM97s, was proposed by CIE TC1-34 in 1997 in response to the needs of the imaging industry for a single, practically-applicable, color appearance model for deviceindependent color imaging applications. CIECAM97s has been successful in focusing a large number of researchers in a single direction to implement, evaluate,...

This note is not to be misunderstood as a general obituary touching all of the many facets of Barry’s personality: the teacher, the researcher, the activist, and, in general, the enthusiastic supporter of good causes. Rather, it should be seen as the author’s personal recollection of the crucial role that Barry played in the transition of Computability in Europe from European network proposal v...

In this paper we approach the problem of fast surface grading of flat pieces decorated with random patterns. The proposed method is based on the use of global statistics of color computed in the CIE Lab space. Two other fast methods based on color histograms [1] and Centile-LBP features [8] are introduced for comparison purposes. We used CIE Lab in order to provide accuracy and perceptual appro...

Many plasma membrane (PM) proteins enter cells nonselectively through clathrin-independent endocytosis (CIE). Here, we present evidence that cytoplasmic sequences in three CIE cargo proteins-CD44, CD98, and CD147-were responsible for the rapid sorting of these proteins into endosomal tubules away from endosomes associated with early endosomal antigen 1 (EEA1). We found that Hook1, a microtubule...