Escherichia coli G3/10 is a component of the probiotic drug Symbioflor 2. In an in vitro assay with human intestinal epithelial cells, E. coli G3/10 is capable of suppressing adherence of enteropathogenic E. coli E2348/69. In this study, we demonstrate that a completely novel class II microcin, produced by probiotic E. coli G3/10, is responsible for this behavior. We named this antibacterial pe...

Multiple Classifier Systems (MCSs) allow evaluation of the uncertainty of classification outcomes that is of crucial importance for safety critical applications. The uncertainty of classification is determined by a trade-off between the amount of data available for training, the classifier diversity and the required performance. The interpretability of MCSs can also give useful information for ...

UNLABELLED The practice of clinical supervision (CS) is recommended for allied health professionals. Preliminary evidence suggests that CS can be effective, but it is unknown for which allied health professions it is most effective. METHOD The effectiveness of CS was measured using the allied health-specific modified Manchester Clinical Supervision Scale (MCSS-26). Subscales of the MCSS-26 we...

MOTIVATION Structural studies of metabolic networks yield deeper insight into topology, functionality and capabilities of the metabolisms of different organisms. Here, we address the analysis of potential failure modes in metabolic networks whose occurrence will render the network structurally incapable of performing certain functions. Such studies will help to identify crucial parts in the net...

We are interested in the specification and deployment of multi-agent systems, and particularly we focus on the execution of agents. Along this research line, we have proposed a general model for graded BDI agents, specifying an architecture based on multi-context systems (MCSs) and able to deal with the environment uncertainty (via graded beliefs) and with graded mental proactive attitudes (via...

In this paper, we apply a digital holographic microscope (DHM) in conjunction with stroboscopic acquisition synchronization. Here, the temperature-dependent decrease of the first resonance frequency (S₁(T)) and Young's elastic modulus (E₁(T)) of silicon micromechanical cantilever sensors (MCSs) are measured. To perform these measurements, the MCSs are uniformly heated from T₀ = 298 K to T = 450...

Unusually long duration and heavy rainfall from 5 to 6 February 2021 caused widespread devastating floods in Semarang, Central Java, Indonesia. The was produced by two mesoscale convective systems (MCSs). first MCS developed at 13Z on over the southern coast of Sumatra propagated towards Semarang. second north Semarang 18Z later led peak precipitation 21Z 2021. These MCSs eventually merged into...

Maintenance of organelle identity is crucial for the functionality of eukaryotic cells. Hence, transfer reactions between different compartments must be highly efficient and tightly regulated at the same time. Membrane contact sites (MCSs) represent an important route for inter-organelle transport and communication independent of vesicular trafficking. Due to extensive research, the mechanistic...

One relatively new computational approach to the drug discovery process involves calculating functional group maps of a target structure. Experimental functional group mapping techniques have also recently emerged. In this paper, the structure of RNase A with two bound formates (i.e. carboxylate functionalities) is used as a model system to test the computational methodology. Functional group m...

Multi-context Systems (MCSs) are a formalism for systems consisting of knowledge bases (possibly heterogeneous and non-monotonic) that are interlinked via bridge rules, where the global system semantics emerges from the local semantics of the knowledge bases (also called “contexts”) in an equilibrium. While MCSs and related formalisms are inherently targeted for distributed settings, no truly d...