The mature T cell receptor (TCR) repertoire is shaped by positive- and negative-selection events taking place during T cell development. These events are regulated by interactions between the TCR and major histocompatibility complex molecules presenting self-peptides. It has been shown that many antagonist peptides are efficient at mediating positive selection. In this study we analyzed the eff...

The first Gröbner basis algorithm was constructed by Buchberger in 1965; thus it bears his name to this day – Buchberger’s algorithm.[9] Though Buchberger’s algorithm looks relatively simple, it can take a very large amount of time. The step that creates 0 h via a normal form calculation is computationally very difficult. This is particularly frustrating (and wasteful) if the normal form calcul...

Orally disintegrating tablets are a solid dosage form compromising medicinal substances which disintegrate rapidly, generally within matter of seconds, when placed on the tongue. In this study, paracetamol orally was formulated and evaluated. Direct compression used to prepare 350 mg five formulations (F1- F5) by using single punch manual tableting machine. Pre-formulation studies were performe...

In this paper, we present an improved approach to the “breaking the F5 algorithm”. The key idea is to search for an “optimal” value of β (the probability that a non-zero AC coefficient will be modified) for the image under consideration. Rather than averaging the values of β for 64 shifting steps worked on an image, an optimal β is determined that corresponds to the shift having minimal distanc...

Despite recent advances in decoding cortical activity for motor control, the development of hand prosthetics remains a major challenge. To reduce the complexity of such applications, higher cortical areas that also represent motor plans rather than just the individual movements might be advantageous. We investigated the decoding of many grip types using spiking activity from the anterior intrap...

In many brain areas, repetition of a stimulus usually weakens the neural response. This "adaptation" or repetition suppression effect has been observed with mass potential measures such as event-related potentials (ERPs), in fMRI BOLD responses, and locally with local field potentials (LFPs) and spiking activity. Recently, it has been reported that macaque F5 mirror neurons do not show repetiti...

The objective of research was to explore the suitability of lipids like compritol 888 ATO and stearic acid as release retardant to develop sustained release (SR) tablets. The SR micromatrices of lipid (s) and glipizide were prepared (LM1- LM6) as intermediate product by fusion method and assessed for various pharmacotechnical properties. Micromatrices were formulated as SR tablets (F1-F6) by di...

The genetic background of complex diseases is proposed to consist of several low-penetrance risk loci. Addressing this complexity likely requires both large sample size and simultaneous analysis of different predisposing variants. We investigated the role of four thrombosis genes: coagulation factor V (F5), intercellular adhesion molecule 1 (ICAM1), protein C (PROC), and thrombomodulin (THBD) i...