نتایج جستجو برای: الگوریتم cul
تعداد نتایج: 23329 فیلتر نتایج به سال:
BACKGROUND We aimed to evaluate the microscopic extent of endometriosis in surgical en-bloc specimens of vaginal skin, rectovaginal septum, cul-de-sac, and part of the rectosigmoid bowel. METHODS From December, 1997 to October, 2001, 50 patients with the trias of intestinal pain, palpable disease in the rectovaginal septum, and laparoscopic diagnosis of endometriosis of the cul-de-sac and/or ...
Genome stability requires that genomic DNA is replicated only once per cell cycle. The replication-licensing system ensures that the formation of prereplicative complexes is temporally separated from the initiation of DNA replication [1-4]. The replication-licensing factors Cdc6 and Cdt1 are required for the assembly of prereplicative complexes during G1 phase. During S phase, metazoan Cdt1 is ...
pVHL, the product of the VHL tumor suppressor gene, plays an important role in the regulation of cell growth and differentiation of human kidney cells, and inactivation of the VHL gene is the most frequent genetic event in human kidney cancer. The biochemical function of pVHL is unknown. Here we report that pVHL exists in vivo in a complex that displays ubiquitination-promoting activity in conj...
Fusarium head blight (FHB) is an important disease of wheat and production mycotoxins makes it a major threat in most wheat-producing areas worldwide. This study aimed to identify the impact epidemic FHB conditions (usage artificial inoculation) on mycotoxin levels unprocessed wheat. were monitored at two locations treatments (natural infection inoculation with graminearum F. culmorum) where 13...
Unscheduled DMA synthesis was induced by procarcinogens in freshly isolated suspensions and primary cul tures (6 days old) of hepatocytes on collagen membranes. Incorporation of ['HJthymidine in the presence of hydroxyurea was used to measure unscheduled DMA synthesis. When hepatocellular DNA was isolated on cesium chlo ride gradients, significant levels of unscheduled DNA synthesis were measur...
SRC-3 is an important coactivator of nuclear receptors including the retinoic acid (RA) receptor α. Most of SRC-3 functions are facilitated by changes in the posttranslational code of the protein that involves mainly phosphorylation and ubiquitination. We recently reported that SRC-3 is degraded by the proteasome in response to RA. Here, by using an RNAi E3-ubiquitin ligase entry screen, we ide...
Video legend: Laparoscopic appearance of adhesions in posterior uterine cul de sac due to previous pelvic inflammatory disease (PID). In the first screen, ovary (white in appearance) is located in the middle, fallopian tube (reddish-tan) is to the left and the metallic tip of the manipulating probe is to the right. In the subsequent frames, the adhesions in the posterior cul de sac. (Quicktime ...
The present study investigates the clinical applicability of a new device, which objectively measured nasal resonating vibration via piezoelectric vibratory sensor in 10 normal volunteers, 10 patients with definite hypernasality, and 10 nasal polyposis patients. For the assessment of the hypernasality, the ratio of /ng/ to /a/ as well as the ratio of /mama/ to /papa/ passages were used. For the...
Variants in cullin 4B (CUL4B) are a known cause of syndromic X-linked intellectual disability. Here, we describe an additional 25 patients from 11 families with variants in CUL4B. We identified nine different novel variants in these families and confirmed the pathogenicity of all nontruncating variants. Neuroimaging data, available for 15 patients, showed the presence of cerebral malformations ...
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