BACKGROUND Cognitive behavioural therapy (CBT), including exposure and ritual prevention, is a first-line treatment for obsessive-compulsive disorder (OCD), but few reliable predictors of CBT outcome have been identified. Based on research in animal models, we hypothesized that individual differences in basolateral amygdala-ventromedial prefrontal cortex (BLA-vmPFC) communication would predict ...

Obsessive compulsive disorder (OCD) has been reported in up to 31% of schizophrenia sufferers. This study evaluated the presence of OCD in a Xhosa-speaking schizophrenia group. Xhosa patients (N = 509, including 100 sibships) with schizophrenia were recruited from hospital and community settings. The patients underwent a structured clinical interview for the presence of lifetime co-morbid schiz...

Psychiatric disorders are difficult to explain from an evolutionary aspect, since it is hard to reason how a characteristic carrying a reproductive disadvantage survives through natural selection. There are several evolution-based papers concerning obsessive-compulsive disorder (OCD), which aim at resolving this contradiction. Recent studies provided considerable evidence in support for the evo...

ISSN 1758-2008 10.2217/NPY.10.1 © 2011 Future Medicine Ltd Neuropsychiatry (2011) 1(1), 61–69 Summary Whilst genetic factors are thought to contribute to the development of obsessive–compulsive disorder (OCD), the role of environmental factors in OCD is only beginning to be understood. In this article, we review the influence of stress-related factors in OCD. Overall, studies indicate that: pat...

the obsessive-compulsive disorder (ocd) is a chronic and disabling neurotic disorder. unit recently the information about the incidence, etiology and treatment of this disorder was based on researches done on relatively small samples. in the past few years, owing to a number of studies done on different populations, public knowledge about this disorder has been increased and patients have been ...

PURPOSES (a) To externally validate the Crippa and colleagues' nomograms combining PSA, percentage of positive biopsy cores (PPBC) and biopsy Gleason score to predict organ-confined disease (OCD) in a contemporary sample of patients treated at a tertiary teaching institution. (b) To adjust such variables, resulting in predictive nomograms for OCD and seminal vesicle invasion (SVI): the USP nomo...

BACKGROUND Serotonergic system dysfunction has been implicated in obsessive-compulsive disorder (OCD). This study examined peripheral SLC6A4 gene expression in OCD patients and healthy controls to explore the relationship between SLC6A4 and OCD. METHODS Participants included 50 first episode OCD patients and 60 age and gender-matched healthy controls. Relative SLC6A4 gene expression were exam...

BACKGROUND AND OBJECTIVES Prior research has indicated a number of neuropsychological deficits in patients with OCD consistent with the cortico-striato-thalamo-cortical model of the disorder. Response inhibition (RI), defined as the inability to inhibit a prepotent response, has been identified as a possible candidate endophenotype for OCD. However, the results from previous studies of RI in OC...

when a literature review on pediatric obsessive-compulsive disorder (ocd) is ‎performed, it is observed that there is a dearth of research on preschool period ocd ‎cases. although cognitive behavioral therapy is recommended as the first line of ‎treatment in preschool ocd cases when patients do not show adequate response to ‎cbt, psychopharmacological treatment offers an alternative. the first ...

Research implicates frontostriatal pathophysiology in both attention deficit/hyperactivity disorder (ADHD) and obsessive-compulsive disorder (OCD). Nevertheless, ADHD is characterized with frontostriatal hypoactivity and OCD with hyperactivity. Furthermore, both disorders seem to lie on opposite ends of a clinical impulsive-compulsive continuum. While never having directly been compared, and de...