يتحدث البحث عن العلاقات السوفيتية – الباكستانية خلال عام 1980 الذي شهد تطورات مهمة على المستوى الإقليمي والدولي لاسيما بعد الاحتلال السوفيتي لأفغانستان في 27 كانون الاول 1979، الامر زاد من توتر ابان ذلك العام وخلق ازمة سياسية علاقات البلدين ظلت اثارها مستمرة لعدة سنوات ، وقد سلط طبيعة وما صاحبها مفاوضات جرت بينهما بشأن حل الازمة الأفغانية .
 قسم الى محورين تضمن المحور الاول: ردود الفعل عقب...

Phospholipase C (PLC) was purified to homogeneity from the culture filtrate of Bacillus cereus (65-fold, 540 U/mg protein) and B. thuringiensis (76-fold, 306 U/mg protein) by conventional techniques of enzyme purification. The purified enzymes have the molecular mass of 34 kDa and 38 kDa respectively, as determined by SDS-PAGE. Both the PLCs exhibited identical sensitivity to pH, temperature, c...

Stimulation of the T cell antigen receptor (TCR) activates a protein tyrosine kinase and leads to the tyrosine phosphorylation of phosphoinositide-specific phospholipase C-gamma 1 (PLC gamma 1). The molecular interactions involved in this phosphorylation are not known. After stimulation of the TCR on Jurkat T cells, tyrosine-phosphorylated proteins of 36, 38, 58, and 63 kD coprecipitate with PL...

Mutational activation of the ras proto-oncogenes is frequently found in skin cancers. However, the nature of downstream signaling pathways from Ras involved in skin carcinogenesis remains poorly understood. Recently, we and others identified phospholipase C (PLC) as an effector of Ras. Here we have examined the role of PLC in de novo skin chemical carcinogenesis by using mice whose PLC is genet...

Panebra, A., S.-X. Ma, L.-W. Zhai, X.-T. Wang, S. G. Rhee, and S. Khurana. Regulation of phospholipase C-g1 by the actin-regulatory protein villin. Am J Physiol Cell Physiol 281: C1046–C1058, 2001.—The actin-regulatory protein villin is tyrosine phosphorylated and associates with phospholipase C-g1 (PLC-g1) in the brush border of intestinal epithelial cells. To study the mechanism of villin-ass...

The 145-kDa phospholipase C isozyme, PLC-gamma, is an excellent substrate for the epidermal growth factor (EGF) receptor both in vivo and in vitro. We now demonstrate that EGF treatment of HSC-1 cells, a human squamous cell carcinoma-derived cell line that expresses high levels of the EGF receptor, rapidly induces tyrosine phosphorylation of two-thirds of the total cellular PLC-gamma pool. A tw...

A protective effect of statins on primary liver cancer (PLC) risk has been suggested. However, issues about the dose-response relationship, the protective effect of individual statins, and PLC risk reduction among at-risk populations remain unsolved. Therefore, a meta-analysis was conducted. PubMed and EMBASE were searched for studies providing the risk ratio (RR) on statins and PLC risk. Summa...

Association of phospholipase C (PLC)-gamma 1 with the cytoskeleton has been postulated to be one of the crucial steps for PLC-gamma 1 activation and translocation to the plasma membrane. In this report, direct binding assays were carried out to study which fragment of PLC-gamma 1 Src homology region has been able to bind to the actin-cytoskeleton. Using GST fusion proteins containing various de...

Phospholipase C (PLC)-mediated hydrolysis of membrane phospholipids results in the production of diacylglycerol, inositol phosphates, and choline metabolites. Inositol triphosphate increases calcium levels, while diacylglycerol activates protein kinase C. The present studies demonstrate that exogenous PLC generates inositol phosphates, releases choline metabolites, and activates protein kinase ...