BACKGROUND Apolipoprotein A5 gene (APOA5) has been shown to modulate plasma triglyceride concentrations. We investigated 2 distinct APOA1/C3/A5 haplotypes roles for hypertriglyceridemia. METHODS We recruited 308 cases of hypertriglyceridemia and 281 normal controls from a hospital. Twelve single nucleotide polymorphisms (SNPs) across the APOA1/C3/A5 gene region were genotyped. RESULTS One h...

UNLABELLED Transgenic mice such as apolipoprotein E-deficient (apoE(-/-)) and low-density-lipoprotein receptor-deficient (LDLR(-/-)) mice exhibit hypercholesterolemia and develop complex atherosclerotic lesions similar to those seen in humans. Radiolabeled annexin A5 has been successfully used to noninvasively image experimental and clinical atherosclerotic disease. We evaluated the feasibility...

We consider generalized Melvin-like solutions corresponding to Lie algebras of rank 5 (A5, B5, C5, D5). The take place in a D-dimensional gravitational model with five Abelian two-forms and scalar fields. They are governed by moduli functions Hs(z) (s=1,...,5) squared radial coordinates z=?2, which obey differential master equations. polynomials powers (n1,n2,n3,n4,n5)=(5,8,9,8,5),(10,18,24,28,...

Bidirectional signaling between Eph receptor tyrosine kinases and their cell-surface protein signals, the ephrins, comprises one mechanism for guiding motor axons to their proper targets. During projection of motor axons from the lateral motor column (LMC) motor neurons of the spinal cord to the hindlimb muscles in chick embryos, ephrin-A5 has been shown to be expressed in the LMC motor axons u...

Annexin A5 has been used for the detection of apoptotic cells, due to its ability to bind to phosphatidylserine (PS). Four different labeled Annexin A5 adducts were evaluated in rhesus monkey, with radiolabeling achieved via 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA). Of these adducts differing conjugation methods were employed which resulted in nonspecific radiolabeling (A...

Vascular development and maturation are dependent on the interactions of endothelial cell integrins with surrounding extracellular matrix. Previous investigations of the primacy of certain integrins in vascular development have not addressed whether this could also be a secondary effect due to poor embryonic nutrition. Here, we show that the a5 integrin subunit and fibronectin have critical rol...

Cell-cell interactions organize lens fiber cells into highly ordered structures to maintain transparency. However, signals regulating such interactions have not been well characterized. We report here that ephrin-A5, a ligand of the Eph receptor tyrosine kinases, plays a key role in lens fiber cell shape and cell-cell interactions. Lens fiber cells in mice lacking ephrin-A5 function appear roun...

A5/1 is a shift register based stream cipher which provides privacy for the GSM system. In this paper, we analyse the loading of the secret key and IV during the initialisation process of A5/1. We demonstrate the existence of weak key-IV pairs in the A5/1 cipher due to this loading process; these weak key-IV pairs may generate one, two or three registers containing all-zero values, which may le...

Huangfu, Donghai, and Patrice G. Guyenet. a2Adrenergic autoreceptors in A5 and A6 neurons of neonate rats. Am. J. Physiol. 273 (Heart Circ. Physiol. 42): H2290– H2295, 1997.—A5 noradrenergic neurons control sympathetic outflow, nociception, and respiration. The presence of a2-adrenergic receptors (a2-ARs) in A5 cells has been suggested by immunohistochemistry. In the present experiments, we ana...