The inflammasome/caspase-1 signaling pathway in immune cells plays a critical role in bacterial pathogenesis; however, the regulation of this pathway in the gastric epithelium during Helicobacter pylori infection is yet to be elucidated. Here, we investigated the effect of catechins (CAs), sialic acid (SA), or combination of CA and SA (CASA) on H. pylori-induced caspase-1-mediated epithelial da...

In late 2006, the NSF Engineering Research Center (ERC) for Collaborative and Adaptive Sensing of the Atmosphere (CASA, McLaughlin et al. 2005) began its first integrated project (IP1, Brotzge et al. 2007). CASA-IP1 consists of a network of four x-band dual-polarization Doppler radars in southwest Oklahoma. During the spring of 2007, this radar network collected data from a number of severe con...

PURPOSE The study objective was to assess the content validity of the Cough and Sputum Assessment Questionnaire (CASA-Q) cough domains and the UCSD Shortness of Breath Questionnaire (SOBQ) for use in patients with Idiopathic Pulmonary Fibrosis (IPF). METHODS Cross-sectional, qualitative study with cognitive interviews in patients with IPF. Study outcomes included relevance, comprehension of i...

Casa Grande is an Indian ruin of undetermined antiquity situated in Pinal County, southern Arizona, a little more than a mile from the left bank of the Gila River. It lies twelve miles from Florence and about eighteen miles from the Casa Grande station on the Southern Pacific Railroad. Casa Grande was given its name about 1694 by its discoverer, the celebrated Jesuit, Father Eusebio Francisco K...

Objective To assess whether cervical spinal cord atrophy heralds the onset of progressive MS. Methods We studied 34 individuals with radiologically isolated syndrome (RIS) and 31 patients with relapsing-remitting MS (RRMS) age matched to 25 patients within a year of onset of secondary progressive MS (SPMS). Two raters independently measured (twice per rater) the cervical spinal cord average seg...

Structure prediction and computational protein design should benefit from accurate solvent models. We have applied implicit solvent models to two problems that are central to this area. First, we performed sidechain placement for 29 proteins, using a solvent model that combines a screened Coulomb term with an Accessible Surface Area term (CASA model). With optimized parameters, the prediction q...

Introduction: The six-minute walking test distance, despite being considered the main parameter, does not consider body weight which is known to influence exercise capacity. A body of evidence * Professor do Centro Universitário Feevale de Novo Hamburgo/ Médico pneumologista do Pavilhão Pereira Filho/ Professor do Programa de Pós Graduação em Ciências Pneumológicas da Universidade Federal do Ri...

This study was designed to determine the ability of computer-assisted sperm morphometry analysis (CASA-Morph) with fluorescence to discriminate between spermatozoa carrying different sex chromosomes from the nuclear morphometrics generated and different statistical procedures in the bovine species. The study was divided into two experiments. The first was to study the morphometric differences b...

Mechanical tension is an ever-present physiological stimulus essential for the development and homeostasis of locomotory, cardiovascular, respiratory, and urogenital systems. Tension sensing contributes to stem cell differentiation, immune cell recruitment, and tumorigenesis. Yet, how mechanical signals are transduced inside cells remains poorly understood. Here, we identify chaperone-assisted ...