The present case report described a 61-year-old female patient who was diagnosed as Meige syndrome with double eyelid spasm, anxiety and insomnia. After she was treated with psychoactive drugs, it was found that clonazepam tablets in the benzodiazepine class and dopamine antagonist olanzapine tablets aggravated double eyelid spasm; while eszopiclone tablets as a specificity γ-aminobutyric acid ...

The present study analyzed expressional changes of excitatory neurotransmitters and inhibitory neurotransmitters in the rat corpus striatum after single-use and combined-use diazepam and Chinese herb moschus. The influence of moschus on the central nervous system was analyzed, in particular whether moschus increased penetration of other drugs into the brain. Reverse-phase high-performance liqui...

Electrical high frequency stimulation is used as treatment for motoricas well as psychomotoric disorders in various regions of the brain. The biochemical mechanisms of the action of high frequency stimulation underlying the effective results are unclear. Previous studies have demonstrated that electrical 130 Hz stimulation was capable of increasing local γaminobutyric acid outflow in the rat ca...

State Key Laboratory of Microbial Resources and Dept. of Industrial 4 Microbiology and Biotechnology, Institute of Microbiology, Chinese Academy of 5 Sciences, Beijing 100101, PR China; Key Laboratory of Agricultural and 6 Environmental Microbiology, Wuhan Institute of Virology, Chinese Academy of 7 Sciences, Wuhan 430071, People's Republic of China 8 9 Running title 10 GABA uptake system in C....

Exposure to high pCO2 or low pH alters sensation and behaviour in many marine animals. We show that crab larvae lose their ability to detect and/or process predator kairomones after exposure to low pH over a time scale relevant to diel pH cycles in coastal environments. Previous work suggests that acidification affects sensation and behaviour through altered neural function, specifically the ac...

We study the conformation and reorientation dynamics of the inhibitory neurotransmitter γ-aminobutyric acid (GABA) under neutral and acidic conditions using a combination of broadband dielectric relaxation spectroscopy and polarization-resolved femtosecond mid-infrared pump-probe spectroscopy. We find that both zwitterionic and cationic GABA adopt nearly linear conformations in aqueous solution...

Abstract Pain is a complex physiological and psychological activity, involving at least three dimensions, including pain sensation, emotion, cognition. Acupuncture can clearly relieve the sensation of patients improve emotion cognition induced by pain; acupuncture participates in multi-dimensional regulation through brain regions limbic system such as anterior cingulate cortex (ACC), amygdala (...

While the amygdala is considered to play a critical role in temporal lobe epilepsy, conclusions on underlying pathophysiological mechanisms have been derived largely from experimental animal studies. Therefore, the present study aimed to characterize synaptic network interactions, focusing on spontaneous interictal-like activity, and the expression profile of transmitter receptors in the human ...

background: there are some reports in the literature showing that hypothalamus synthesizes and secretes amino acid neurotransmitters. according to several studies, elevated serum levels of gamma-amino butyric acid (gaba), a potent inhibitory neurotransmitter, have recently been implicated in the pathogenesis of neural diseases. the purpose of this research was to estimate the effects of curcumi...