OBJECTIVES To determine the diagnostic value of beta 2 microglobulin in parotid saliva, its concentration in relation to salivary flow was determined in 29 patients with primary Sjögren's syndrome and in 30 normal controls. The specific secretion rate of beta 2 microglobulin was calculated. METHODS Parotid saliva samples were collected within a 20 minute period directly from Stensen's duct wi...

Crystals of the bovine milk protein lactollin yield x-ray diffraction data extending to a resolution of 2.8 A. Lactollin is a bovine analogue of #2-microglobulin, a protein that is homologous in amino acid sequence to the constant domains of immunoglobulins and is the light chain of the human and murine major histocompatability antigens. The protein crystallizes in the orthorhombic space group ...

Klebsiella pneumoniae is a leading cause of both community-acquired and nosocomial gram-negative bacterial pneumonia. A significant clinical complication of Klebsiella pulmonary infections is peripheral blood dissemination, resulting in a systemic infection concurrent with the localized pulmonary infection. We report here on the critical importance of 2-microglobulin expression during murine K....

Incubation of purified human 82-microglobulin (B2-m) with tissue transglutaminase (Tgase) resulted in the formation of high molecular weight polymers revealed by sodium dodecyl sulfate polyacrylamide gel electrophoresis. In the presence of 30 mM ['4C]methylamine, the polymer formation was prevented, but incorporation of methylamine into ,8 2-m (equal to 1 methylamine per 1 molecule) could be ob...

A patient receiving haemodialysis for 15 years developed systemic amyloidosis of I2 microglobulin type. Noticeable deposits of amyloid were present in the myocardium, intervertebral discs, joint cartilages and tendons. Less conspicuous amounts were present in blood vessel walls in the lungs, liver, adrenal glands and brain, and within the stroma of the prostate, testis and kidney, often with fo...

Beta-2 microglobulin (B2M) is an immune system protein that found on the surface of all nucleated human cells. B2M naturally shed from cell surfaces into plasma, followed by renal excretion. In patients with impaired function, will accumulate in organs and tissues leading to significantly reduced life expectancy quality life. While current hemodialysis methods have been successful managing elec...

Sempatik sinirlerin insan vücudunda çeşitli etkilere yol açtığı 19.yüzyıldan itibaren bilinmektedir. Birden fazla adrenerjik reseptör olduğu Ahlquist tarafından ilk olarak 1948 yılında ileri sürülmüş ve birçok araştırıcı bu reseptörlerin sayısının bilinmediği ifade edilmiştir. Daha sonra 1984 Arch adlı bilim adamı kemirgenlerde beyaz kahverengi yağda atipik bir β adrenoseptor (AR) varlığı ortay...

An enzyme-linked immunosorbent assay (ELISA) for urinary retinol-binding protein (RBP) has been developed and compared with urinary beta 2-microglobulin for the detection of tubular proteinuria. The assay has a working range of 10 to 250 micrograms of RBP per liter of urine. The within-assay CV was 3.2-7.1%, the between-assay CV 12.5%. A control population of 118 male subjects gave a geometric ...