نتایج جستجو برای: β lactam
تعداد نتایج: 181457 فیلتر نتایج به سال:
Resistance to drugs/antibiotics in pathogenic bacteria is a growing clinical concern, and the spread of resistant strains worldwide has been discombobulating public health, everywhere, exemplified with Pseudomonas, Staphylococcus and a few more pathogens[1]. Particularly, β-lactam antibiotics were known to be equally active against both Gram-positive and Gram-negative bacteria. But, the range o...
We present here the draft genome of Bacillus toyonensis VU-DES13, which was isolated from the midgut of the soil-living springtail Folsomia candida Previous research revealed the presence of gene clusters for the biosynthesis of various secondary metabolites, including β-lactam antibiotics, in the host's genome. The genome data are discussed in the light of the antimicrobial properties against ...
In the title compound, C26H27N3O5, the β-lactam (azetidin-2-one) ring is nearly planar [maximum deviation = 0.011 (3) Å]. The mean plane formed by the four C atoms of the morpholine ring, which adopts a chair conformation, the benzene ring and the naphthalene ring system form dihedral angles of 72.85 (17), 87.46 (15) and 65.96 (11)°, respectively, with the β-lactam ring. In the crystal, molecul...
The central β-lactam ring of the title compound, C(23)H(21)NO(3), is almost planar (r.m.s. deviation = 0.032Å). The meth-oxy-benzene ring is almost coplanar with the β-lactam ring [dihedral angle = 1.87 (11)°], whereas the tolyl ring is almost normal to it [75.73 (12)°]. The dihedral angle between the β-lactam ring and the O-bonded phenyl ring is 51.95 (12)°. An intra-molecular C-H⋯O inter-acti...
Mycobacterium tuberculosis (M. tuberculosis) is considered innately resistant to β-lactam antibiotics. However, there is evidence that susceptibility to β-lactam antibiotics in combination with β-lactamase inhibitors is variable among clinical isolates, and these may present therapeutic options for drug-resistant cases. Here we report our investigation of susceptibility to β-lactam/β-lactamase ...
Background and purpose: Acinetobacter has emerged as a significant opportunistic pathogen responsible for nosocomial infections. Treatment of infections due to this organism is becoming a serious clinical concern and this bacterium is frequently resistant to multiple classes of antibiotics such as family of β-lactam drugs. β-lactamases enzyme represent the main mechanism of bacterial resista...
In an approach to the biologically important 6-azabicyclo[3.2.1]octane ring system, the scope of the tandem 4-exo-trig carbamoyl radical cyclization-dithiocarbamate group transfer reaction to ring-fused β-lactams is evaluated. β-Lactams fused to five-, six-, and seven-membered rings are prepared in good to excellent yield, and with moderate to complete control at the newly formed dithiocarbamat...
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