Ursolic acid (UA) and oleanolic acid (OA) are insoluble drugs. The objective of this study was to encapsulate them into β-cyclodextrin (β-CD) and compare the solubility and intermolecular force of β-CD with the two isomeric triterpenic acids. The host-guest interaction was explored in liquid and solid state by ultraviolet-visible absorption,1 H NMR, phase solubility analysis, and differential s...

Dicarboxylic organic acids have properties that differ from those of sulfuric acid during hydrolysis of lignocellulose. To investigate the effects of different acid catalysts on the hydrolysis and degradation of biomass compounds over a range of thermochemical pretreatments, maleic, oxalic and sulfuric acids were each used at the same combined severity factor (CSF) values during hydrolysis. Xyl...

2-AS: 2-(9-anthroyloxy)stearic acid 12-AS: 12-(9-anthroyloxy)stearic acid 25-NBD-cholesterol: 25-[N-[(7-nitrobenz-2-oxa-1,3-diazol-4-yl)-methyl]amino]27norcholesterol DOPC: dioleoyl-sn-glycero-3-phosphocholine MβCD: methyl-β-cyclodextrin NBD: 7-nitrobenz-2-oxa-1,3-diazol-4-yl NBD-PE: N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)-1,2-dipalmitoyl-sn-glycero-3-pho sphoethanolamine REES: red edge excitatio...

Article history: Received on: 26/07/2015 Revised on: 15/08/2015 Accepted on: 09/09/2015 Available online: 27/09/2015 Objective To evaluate the effect of Polyethylene glycol and β-cyclodextrin on the solubility and dissolution of silymarin, a poorly water soluble herbal drug. Methodology Effects of beta cyclodextrins and Polyethylene glycol on solubility of silymarin were evaluated by phase solu...

Well-defined star-like amphiphilic polymers composed of a β-cyclodextrin core, from which 21 hydrophobic poly(lactic acid) arms and hydrophilic poly(ethylene glycol) arms are grafted sequentially, form robust and uniform unimolecular micelles that are biocompatible and efficient in the delivery of anticancer drugs.

We describe here the sugar functionalized β-cyclodextrin-ferrocene glass slides as fully reversible bacterial biosensors under the influence of external adamantane carboxylic acid. The prototype d-mannose - E. coli ORN 178 and l-fucose - P. aeruginosa interactions serve as a model to illustrate the new approach.

A non-classic complexation mode was discovered upon spectroscopic, thermodynamic, crystallographic and computational studies of a β-cyclodextrin/propionic acid complex. A "fully immersed" complexation phenomenon, where both the guest's hydrophobic and polar moieties are located inside the host and are stabilized by it, was found and calculated as the most favorable configuration.

Fexofenadine is a selective histamine H(1) receptor antagonist, used for relief of the symptoms of allergy. However its aqueous solubility is very poor. Solid inclusion complexes of fexofenadine and β-cyclodextrin were prepared at the molar ratios of 1:1 and 1:2 by kneading, and coprecipitation methods to improve its solubility. Characterization of the complexes was performed using infrared spe...

Feeding states may affect the performance of colonic prodrugs. The aim is to investigate the influence of feeding regimen in Wistar rats on: (i) distribution and pH contents along the gut and (ii) metabolism of two colonic prodrugs, diclofenac-β-cyclodextrin and a commercially available control, sulfasalazine, within the caecal and colonic contents. Male Wistar rats were subject to four differe...

The incidence of Lactococcosis caused by Lactococcus garvieae, in rainbow trout (Oncorhynchus mykiss, Walbaum, 1792) farms is disquieting and increasing in recent years. Knowledge of biotypes and serotypes involved in disease incidence is essential to adopt disease prevention and control policies. Twelve isolates of L. garvieae from some rainbow trout farms were identified by phenotypic, bioche...