Medicinal plants are the local heritage with global importance playing a vital role in world health care system of developing countries. Calotropis procera (Asclepiadaceae), a giant milk weed, is known for its pharmacological importance for centuries. The coarse shrub is a very promising source of anticancerous, ascaricidal, schizonticidal, anti-microbial, anthelmintic, insecticidal, anti-infla...

Licorice (roots and stolons of Glycyrrhiza plants, Leguminosae) is a well-known natural sweetener, and its sweet constituent is an oleanane-type triterpene saponin, glycyrrhizin. Cultured cells of G. glabra do not produce glycyrrhizin, but produce two structurally different triterpenoid constituents, betulinic acid and soyasaponins. Both glycyrrhizin and soyasaponins are oleanane-type triterpen...

BACKGROUND Metabolic engineering is an attractive approach in order to improve the microbial production of drugs. Triterpenes is a chemically diverse class of compounds and many among them are of interest from a human health perspective. A systematic experimental or computational survey of all feasible gene modifications to determine the genotype yielding the optimal triterpene production pheno...

The evolution of the ability to synthesize specialized metabolites is likely to have been key for survival and diversification of different plant species. Oats (Avena spp.) produce antimicrobial triterpenoids (avenacins) that protect against disease. The oat beta-amyrin synthase gene AsbAS1, which encodes the first committed enzyme in the avenacin biosynthetic pathway, is clearly distinct from ...

Abroma augusta (L.) L. f. has been used as traditional medicine by tribal women in India, Bangladesh forms ancient times. Ayurvedic medicine, derived from herbal plants is to reduce the gamble effects of synthetic drugs. In homeopathy, it using successfully for a long period. Major Phytochemicals such as, Taraxerol, Friedelin, β-Sitosterol, α-Amyrin, Lupeol, Octacosanol, have potentialities con...

To evaluate possible new drugs for the treatment of Colorectal Carcinoma (CRC) using in silico tools was main objective this study. The method analysis used evaluation tumor markers and their interaction with selected drugs, through study its pharmacokinetic pharmacodynamic characteristics. A potential therapeutic target pointed out Cell Division Cycle 25 B (CDC25B), belonging to CDC25 phosphat...

Developing and germinating pea seeds were compared with respect to their capacity to incorporate mevalonate into sterols and triterpenes. The capacity for sterol synthesis is greatest in the least mature fruits and decreases during their development. Label is shown, by gas-liquid chromatography and counting the radioactivity of trapped fractions, to be associated with campesterol, beta-sitoster...