There has been considerable debate about the reasons for the association observed between cannabis use and psychosis in both clinical and general population samples. Among the hypotheses proposed to explain the association are the following: 1) common factors explain the co-occurrence; 2 cannabis causes psychosis that would not have occurred in the absence of cannabis use; 3) cannabis precipita...

The dopamine hypothesis has been the major pathophysiological theory of psychosis in recent decades. Molecular imaging studies have provided in vivo evidence of increased dopamine synaptic availability and increased presynaptic dopamine synthesis in the striata of people with psychotic illnesses. These studies support the predictions of the dopamine hypothesis, but it remains to be determined w...

Korea, like other nations, is experiencing a demographic transition featuring the rapid expansion of the proportion of aged persons. Elderly-related mental health issues are gaining prominence. Late-onset psychosis, which has been a well-recognized but poorly-understood phenomenon, has emerged as an important issue in geriatrics. It is unclear whether this psychosis occurs for the first time at...

The files of 60 cases who received a diagnosis of epileptic psychosis in the period 1980-1985 were reviewed. Unclassifiable psychosis and paranoid hallucinatory states were the most common presentations. Except for the gap between onset of epilepsy and psychosis, there were no other predictors of type of psychosis. Shorter psychotic episodes tended to be characterised by pressure of speech, ina...

The concept of a clinical high-risk state for psychosis has been used to describe individuals who have prodromal symptoms of psychosis and, thus, are at high-risk of developing psychosis. This high-risk concept promotes a more detailed developmental understanding of the evolution of psychosis and provides a theoretical basis for providing necessary mental health services to people at clinically...

BACKGROUND Psychiatric taxonomists have sometimes argued for a unitary psychosis syndrome and sometimes for a pentagonal model, including 5 diagnostic constructs of positive symptoms, negative symptoms, cognitive disorganization, mania, and depression. This continues to be debated in preparation for impending revisions of the Diagnostic and Statistical Manual of Mental Disorders and the Interna...

BACKGROUND The suffering people experience following a first episode of psychosis is great, and has been well-investigated. Conversely, potential positive outcomes following a first episode of psychosis have been under-investigated. One such outcome that may result from a first episode of psychosis is posttraumatic growth, or a positive aftermath following the trauma of a first psychotic episod...

OBJECTIVE There has been growing interest in the use of cognitive analytic therapy (CAT) with those facing experiences of psychosis. However, there is little research on how CAT is best applied to working with psychosis. This study aimed to identify what the key aspects of CAT for psychosis are or whether this approach requires adaptation when applied to those with experiences of psychosis, dra...

BACKGROUND The individual risk of developing psychosis after being tested for clinical high-risk (CHR) criteria (posttest risk of psychosis) depends on the underlying risk of the disease of the population from which the person is selected (pretest risk of psychosis), and thus on recruitment strategies. Yet, the impact of recruitment strategies on pretest risk of psychosis is unknown. METHODS ...

BACKGROUND Psychoses such as hallucinations are a frequent non-motor problem in patients with Parkinson disease (PD) and serious psychosis requires anti-psychotic medications that worsen Parkinsonism. Although psychosis could be associated with patient-related or biological factors such as cognition, age, and severity of PD, it can also be associated with medications.Therefore we aimed to inves...