Selective placement of an aliphatic â-alanine (â) residue paired side-by-side with either a pyrrole (Py) or imidazole (Im) aromatic amino acid is found to compensate for sequence composition effects for recognition of the minor groove of DNA by hairpin pyrrole-imidazole polyamides. A series of polyamides were prepared which contain pyrrole and imidazole aromatic amino acids, as well as γ-aminob...

Small-cell carcinoma of the lung is a highly lethal form of cancer associated with a wide variety of paraneoplastic syndromes. Using the patch-clamp technique, we have directly demonstrated the presence of voltage-gated k4. Na4, and (a24 channels in three cell lines of human small-cell carcinoma, NCI-HI28, NCI-H69, and NCI-HI46. Whole-cell currents were measured from the tumor cells held at —...

Small-cell carcinoma of the lung is a highly lethal form of cancer associated with a wide variety of paraneoplastic syndromes. Using the patch-clamp technique, we have directly demonstrated the presence of voltage-gated k4. Na4, and (a24 channels in three cell lines of human small-cell carcinoma, NCI-HI28, NCI-H69, and NCI-HI46. Whole-cell currents were measured from the tumor cells held at —...

Several human monoclonal antibodies directed to tumor-associated glycolipid antigens have been established, but more than one-half of them react with gangliosides and the others react with neutral glycolipids. We report here the first establishment of a human IgM monoclonal antibody directed to the sulfated glycolipid. This monoclonal antibody, M14-376, did not react with SM<and Sm„ which hav...

â â â â â â â  abstract â  the present research aims to identify effective factors on the reduction of social cooperation with the purpose of attracting social cooperation in directing city zones (zone number 3 in shiraz).the methodology of this research was based on documentary and survey methods. the statistical sample of this research contains people 18 years old and over who live in zone nu...

We suggest and investigate a scheme for non-deterministic noiseless linear amplification of coherent states using successive photon addition, (â(†))(2), where â(†) is the photon creation operator. We compare it with a previous proposal using the photon addition-then-subtraction, ââ(†), where â is the photon annihilation operator, that works as an appropriate amplifier only for weak light fields...

Mechanisms for resistance were studied in three classic type, human small cell lung cancer cell lines, (.!(,,, (.I.(',„,and <;i.<',.i, that were established from one patient during clinical follow-up. Clinically the tumor changed from sensitive (<;!,(,,) to completely resistant to (chemo)therapy ((il.(.',,,) during this period. The stain with JSB-1 anti body, detecting the M, 170,000 multidru...

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â â â  moral values of shanfara in , lamyat- alarab ode â  â  somayeh kazemi * â  jafar delshad ** â  â  in this descriptive-analytic study, the researchers aimed to study the verses of lamyat- al arab and examine the moral values and mental pains which made the poet shanfara express such values. â  this survey has been affected by a hadith that indicates the tendency of the poet to the moral v...