Ali Akbar Moosavi-Movahedi
IBB, Universiy of Teharn
[ 1 ] - Three Decades of Continuous Records for Biophysical Chemistry Laboratory (BCL)
The Biophysical Chemistry Laboratory (BCL) was established in 1986 at Institute of Biochemistry and Biophysics (IBB), University of Tehran as the main base and the mother of biophysical chemistry in Iran. BCL is a famous worldwide research lab in the area of thermodynamics of protein denaturation and biomacromolecular interaction. The first student that joined BCL was MSc student in 1987, while...
[ 2 ] - Fasting Reduces the Binding between Sugar and Protein; New Insights into Diabetic Complications
Fasting has numerous biological, physical and mental health advantages or that as some physicians cure their patients by prescribing fasting to them. Fasting protects people from many diseases such as cancer, cardiovascular diseases, and diabetes complications. The main health-promoting effects of fasting are increased production of neurotrophic factors, neuroendocrine activation, hormetic stre...
[ 3 ] - Protein Stability, Folding, Disaggregation and Etiology of Conformational Malfunctions
Estimation of protein stability is important for many reasons: first providing an understanding of the basic thermodynamics of the process of folding, protein engineering, and protein stability plays important role in biotechnology especially in food and protein drug design. Today, proteins are used in many branches, including industrial processes, pharmaceutical industry, and medical fields. A...
[ 4 ] - Studies of Interaction between Propranolol and Human Serum Albumin in the Presence of DMMP by Molecular Spectroscopy and Molecular Dynamics Simulation
The interaction between propranolol (PROP) and human serum albumin (HSA) was studied in the presence of dimethyl methylphosphonate (DMMP). DMMP is usually considered as a simulant for chemical warfare agents (CWAs). For this purpose fluorescence quenching, resonance light scattering (RLS), synchronous, three-dimensional fluorescence spectroscopy and molecular dynamics (MD) simulation were emplo...
[ 5 ] - Change in Oxygen Absorption of Human Adult and Fetal Hemoglobin Due to 940 MHz Electromagnetic Field Radiation Exposure
The effects of electromagnetic fields (EMFs) radiation at the frequency of 940 MHz on the structure and function of human adult and fetal hemoglobin (HbA and HbF) were studied. After extraction and purification of HbA and HbF, the oxygen absorption values for exposed and unexposed HbA and HbF to EMF were compared. The slope of oxygen absorption curve for exposed HbA was increased while that for...
[ 6 ] - Fructation Induces Hemin Degradation in Methemoglobin
Under prolonged diabetic conditions, HbA1c is produced from normal hemoglobin (HbA0) through a non-enzymatic glycosylation or glycation, a process which enhances the hemoglobin susceptibility to be auto-oxidized to methemoglobin (metHb). Here we are reporting that the non-enzymatic reaction between fructose and metHb (metHb fructation) induces significant changes in the gl...
[ 7 ] - A tri state mechanism for oxygen release in fish hemoglobin: Using Barbus sharpeyi as a model
Hemoglobin is a porphyrin containing protein with an a2b2 tetrameric structure and like other porphyrin compounds shows spectral behavior of species specific characteristics. Researchers tend to relate bands in the hemoglobin spectra to certain structural and/or functional features. Given the fact that hemoglobin is the main oxygen carrier in animals functioning through the Oxy«Deoxy equilibriu...
[ 8 ] - Aggregation of adult and fetal hemoglobin by ingested nitrate anions
The ingested nitrates sourced from tap water, food, chemicals and pharmaceuticals areconverted to nitrites in the body surfaces by bacteria and then, the nitrite ions can lead thestructural changing in hemoglobin. In the present work, aggregation of the purified hemoglobinin adult (HbA) and in fetus or newborn (HbF) in the presence of nitrite ions were studied.Hemoglobin aggregation was perform...
[ 9 ] - کورکومین، ملکول نیروهای چندگانه، تعدیل کننده بیولوژیکی و اثرات درمانی آن
کورکومین ماده فعال بیولوژیک زردچوبه، دارای خواص بیولوژیکی گسترده‌ای، مانند ضد التهاب، آنتی‌اکسیدان، ضد دیابت و ضد سرطان می‌باشد. اگرچه به علت حلالیت کم این ماده در آب، استفاده از خواص دارویی و بیولوژیکی آن محدود است، اما با وجود دسترسی محدود در سطح فعالیت بیولوژیکی، کورکومین در سیستم گوارشی انسان و سیستم‌های دفاعی بدن، اثرات مثبت و قابل توجهی را نشان داده است و مهارکننده انواع مختلفی از بیماری ...
[ 10 ] - اثر شیر شتر در کنترل گلایسمی و پروفایل لیپیدی بیماران دیابتی: کارآزمایی بالینی تصادفی
مقدمه: مطالعه‌ی حاضر با هدف بررسی اثر شیر شتر بر قند خون و پروفایل لیپیدی بیماران مبتلا به دیابت که از انسولین طولانی اثر استفاده می‌کنند، انجام گرفت. مواد و روش‌ها: در این کارآزمایی بالینی، 40 بیمار مبتلا به دیابت شیرین مصرف‌کننده‌ی انسولین طولانی اثر به طور تصادفی در دو گروه دریافت‌کننده شیر شتر (19 نفر با میانگین سنی 05/1±84/59 سال) و شیر گاو (17 نفر با میانگین سنی 93/2±47/49 سال) قرارگرفتند...
[ 11 ] - استفاده از گرماسنجی روبشی تفاضلی در تشخیص مراحل اولیه سرطان‌ها: گزارش کوتاه
Background: Cancer is the most common cause of death in the world, and it incidence has been increasing for many years in economically developed countries. Early detection of cancers greatly increases the chances for successful treatment. So finding cancers before they start to cause symptoms is a most effective treatment. Recent studies have proposed that blood plasma contains a rich source of...
[ 12 ] - Effect of L-Arginine Modified Magnetic Nanoparticles (RMNPs) on Lysozyme in the Presence or Absence of Urea
L-Arginine (Arg or R) is a non-toxigenic, metabolically versatile and conditionally essential amino acid. Single-pot synthesis of Arg modified magnetic nanoparticles (RMNPs) was achieved using magnetite nanoparticles (MNPs) and binary function of Arg as a functional group and an alkali precipitator. This modification is supposed to offer several advantages to the MNPs from a bio-application vie...
نویسندگان همکار