Mohammad Ramezani

[ 1 ] - Chemical composition, antimicrobial activity and antiviral activity of essential oil of Carum copticum from Iran

Objectives: Evaluation of therapeutic effects of Carum copticum (C. copticum) has been the subject of several studies in recent years. Thymol the major component of C. copticum is a widely known anti-microbial agent. In this study, the antibacterial and anti viral activities of essential oil of C. copticum fruit were determined. Materials and Methods: Essential oil of C. copticum was analyzed ...

[ 2 ] - Phototoxicity activity of Psoralea drupacea L. using Atremia salina bioassay system

Objective: Phototoxicity is a kind of dermatitis that is activated by exposure to ultraviolet light following the administration of some drugs or natural products. Artemia salina (A. salina) (brine shrimp) has been effectively applied for toxicity testing and is perfect for biological screening of many chemicals for simultaneous evaluation of toxicity and phototoxicity. The objective of this st...

[ 3 ] - Comparative proteome analysis of human esophageal cancer and adjacent normal tissues

Objective(s): Ranking as the sixth commonest cancer, esophageal squamous cell carcinoma (ESCC) represents one of the leading causes of cancer death worldwide. One of the main reasons for the low survival of patients with esophageal cancer is its late diagnosis. Materials and Methods: We used proteomics approach to analyze ESCC tissues with the aim of a better understanding of the malignant mech...

[ 4 ] - The Effects of Low Level Laser Therapy on the Expression of Collagen Type I Gene and Proliferation of Human Gingival Fibroblasts (Hgf3-Pi 53): in vitro Study

  Objective(s): Recent investigations show that both proliferation and secretion of macromolecules by cells can be regulated by low level laser therapy (LLLT). The aim of this study was to determine whether LLLT could induce a bio-stimulatory effects on human gingival fibroblasts (HGF3-PI 53). Therefore, the effect of laser irradiation on human gingival cell proliferation and collage...

[ 5 ] - The Effect of Cationic Charge Density Change on Transfection Efficiency of Polyethylenimine

[ 6 ] - Development and Validation of HPLC Method for Determination of Crocetin, a constituent of Saffron, in Human Serum Samples

Objective(s):The present study reports the development and validation of a sensitive and rapid extraction method beside high performance liquid chromatographic method for the determination of crocetin in human serum. Materials and Methods:The HPLC method was carried out by using a C18 reversed-phase column and a mobile phase composed of methanol/water/acetic acid (85:14.5:0.5 v/v/v) at the flow...

[ 7 ] - Immunoinhibitory Effect of Teuclatriol a Guaiane Sesquiterpene from Salvia mirzayanii

Background: Salvia mirzayanii, a native plant to Iran, is shown to have immunomodulatory effects on lymphocyte proliferation. Objective: To identify the bioactive immunomodulatory compound(s) present in S. mirzayanii. Methods: The crude extract was fractionated to five fractions in two steps using different solvents. The fractions were subjected to bioassay-guided fractionation. All the fractio...

[ 8 ] - The Therapeutic Effect of Zinc Sulfate on Neonatal Hyperbilirubinemia

Background: Approximately 60% of term neonates and 80% of preterm ones suffer from hyperbilirubinemia in theirfirst week of life. This study sought to characterize the therapeutic effect of oral zinc sulfate on neonatalhyperbilirubinemia.Methods: In this randomized, double-blind, placebo-controlled clinical trial, 70 term neonates with total serumbilirubin (TSB) level ≥ 20 mg/dl were enrolled. ...

[ 9 ] - Effects of oral zinc sulfate on hyperbilirubinemia in low-birth-weight neonates

Background: Hyperbilirubinemia is one of the most common and persistent problems encountered in preterm newborns. This condition in preterm infant is more likely to be associated with neurological damage rather than terms. So far, no major studies have precisely assessed the effects of zinc sulfate on hyperbilirubinemia in low-birth-weight (LBW) neonates. Therefore, in this study, we aimed to e...

[ 10 ] - Prophylactic effect of zinc sulphate on hyperbilirubinemia in premature very low birth weight neonates: a randomized clinical trial

Introduction: One of the common problems in neonatal period is jaundice that occurs in the first week of birth in 60% of term and 80% of preterm neonates. In preterm newborn hyperbilirubinaemia is higher, persistent, longer, and more likely to be associated with neurological injury than term neonates. The purpose of this study was to determine Prophylactic effect of zinc sulphate on hyperbiliru...

[ 11 ] - Preparation, optimization and toxicity evaluation of (SPION-PLGA) ±PEG nanoparticles loaded with Gemcitabine as a multifunctional nanoparticle for therapeutic and diagnostic applications

The aim of this study was to develop a novel multifunctional nanoparticle, which encapsulates SPION and Gemcitabine in PLGA±PEG to form multifunctional drug delivery system. For this aim, super paramagnetic iron oxide nanoparticles (SPIONs) were synthesized and encapsulated simultaneously with Gemcitabine (Gem) in PLGA±PEG copolymers via W/O/W double emulsification method. Optimum size and enca...

[ 12 ] - Colorimetric gold nanoparticles-based aptasensors

Recognition of different agents including chemical and biological plays important role in forensic, biomedical and environmentalfield.In recent decades, nanotechnology and nano materials had a high impact on development of sensors. Using  nanomaterials in construction of biosensors can effectively improve the Sensitivity and other features of biosensors. Different type of nanostructures includi...

[ 13 ] - Preparation, optimization and toxicity evaluation of (SPION-PLGA) ±PEG nanoparticles loaded with Gemcitabine as a multifunctional nanoparticle for therapeutic and diagnostic applications

The aim of this study was to develop a novel multifunctional nanoparticle, which encapsulates SPION and Gemcitabine in PLGA±PEG to form multifunctional drug delivery system. For this aim, super paramagnetic iron oxide nanoparticles (SPIONs) were synthesized and encapsulated simultaneously with Gemcitabine (Gem) in PLGA±PEG copolymers via W/O/W double emulsification method. Optimum size and enca...

[ 14 ] - Pentoxifylline Decreases Serum Level of Adhesion Molecules in Atherosclerosis Patients

Background: Inflammation is involved in development, progression, and complications of atherosclerotic disease. Clinical studies have indicated that the level of monocyte chemoattractant protein 1 (MCP-1), IL-18, and adhesion molecules correlates with the severity of atherosclerosis and can predict future cardiovascular events. Experimental studies have shown pentoxifylline (PTX) reduces these ...

[ 15 ] - تهیه و ارزیابی نانوحامل های پلیمری حاصل از اتصال پلی اتیلن ایمین به پلی ال لیزین با استفاده از لینکر 10 کربنه به منظور انتقال ژن به سلول یوکاریوتی

Background & Aim: A lack of efficient gene-delivery carriers has always been the biggest challenge in gene therapy. Polyethylenimine (PEI) and poly (L-lysine) (PLL) are the most studied non-viral gene carriers. The purpose of this study is to prepare new nano-carriers, by conjugating these two polymers via 10 carbon linkers (10-bromodecanoic acid), in order to take advantage of them and compens...

[ 16 ] - Synthesis of new biodegradable nanocarriers for SN38 delivery and synergistic phototherapy

Objective (s): SN38 is the prominent and effective anticancer drug for treating various types of human cancers such as colorectal, ovarian and lung cancers. SN38 is highly toxic, and due to its poor solubility in aqueous media, and low stability and hydrolysis at physiological pH, it has not been used as an anti-cancer drug. To overcome these problems, SN38 was conjugated with new nanocarriers ...

[ 17 ] - Evaluation of leishmanicidal effect of Euphorbia petiolata extract by in vivo anti-leishmanial assay using promastigotes of Leishmania major

Objective: The extract of different species of Euphorbia has been successfully used as a remedy for treatment of cutaneous leishmaniasis. The aim of this study was to assess the in vitro leishmanicidal effect of Euphorbia petiolata (E. petiolata) extract. Materials and Methods: Ethanolic percolated and methanolic Soxhlet extract of E. petiolata on promastigotes of L. major at different concentr...

[ 18 ] - The effects of crocetin, extracted from saffron, in chemotherapy against the incidence of multiple drug resistance phenotype

Objective(s): Crocetin, one of the main substances of saffron extract, has anti-cancer effects. Drug resistance proteins (e.g. MRP1 and MRP2) are important reasons for the failure of cancer therapy. We intended to investigate the efficacy of crocetin on MRP1 and MRP2 activity in human ovarian cisplatin-resistant carcinoma cell line (A2780-RCIS).Materials and Methods: The cytotoxic effect of cro...

[ 19 ] - تهیه و تعیین خصوصیات گرافن اکساید عامل دار شده با گاما-سیکلودکسترین و نانو ذرات سوپر پارامغناطیس اکسیدآهن به عنوان نانو حامل جدید برای دارو رسانی

با وجود آنکه داروهای خوراکی بهترین انتخاب برای دارو رسانی است، ولی بسیاری از ترکیبات دارویی از جمله ضدسرطان ها با ساختار آروماتیک، محلولیت پایینی در آب و مایعات بیولوژیکی دارند، این امر موجب کاهش مقدار و سرعت جذب این مواد دارویی و در نهایت منجر به محدودیت استفاده از آن ها در درمان بیماری ها می شود. علم نانو با خصوصیات منحصر به فرد خود بسیاری از این محدودیت ها را کاهش داده است؛ به گونه ای که با ...

[ 20 ] - Effect of Mothers' Educational Supportive Care Program on Pain Intensity and Crying Duration Caused by Colic Pain in Infants Aged 1-5 Months

Background: Baby colic is one of the most common digestive problems in infants. Due to its several and unknown causes, colic treatment depends on the parent's individual and social education and support. Aim: This study aimed to determine the effect of mothers' educational supportive care program on the pain intensity and crying caused by colic in infants...

[ 21 ] - In-vitro Study of Multifunctional PLGA-SPION Nanoparticles Loaded with Gemcitabine as Radiosensitizer Used in Radiotherapy

This study aimed to modify the biological response of cells to ionizing radiation by combination therapy using radio-sensitizer agent and anticancer drug. Super paramagnetic iron oxide nanoparticles (SPIONs) were prepared and used with gemcitabine (Gem). These two agents were encapsulated simultaneously intopoly (D, L-lactic-co-glycolic acid) (PLGA) to form multifunctional drug delivery system....

[ 22 ] - In-vitro Study of Multifunctional PLGA-SPION Nanoparticles Loaded with Gemcitabine as Radiosensitizer Used in Radiotherapy

This study aimed to modify the biological response of cells to ionizing radiation by combination therapy using radio-sensitizer agent and anticancer drug. Super paramagnetic iron oxide nanoparticles (SPIONs) were prepared and used with gemcitabine (Gem). These two agents were encapsulated simultaneously intopoly (D, L-lactic-co-glycolic acid) (PLGA) to form multifunctional drug delivery system....

[ 23 ] - A novel formulation of Mtb72F DNA vaccine for immunization against tuberculosis

Objective(s): Mycobacterium tuberculosis (M. tuberculosis), an intracellular pathogen, causes 1.5 million deaths globally. Bacilli Calmette-Guérin (BCG) is commonly administered to protect people against M. tuberculosis infection; however, there are some obstacles with this first-generation vaccine. DNA vaccines, the third generation vaccines, can induce cellular immun...

[ 24 ] - Silica -magnetic inorganic hybrid nanomaterials as versatile sensing platform

Several hybrid sensing materials, which are organized by interaction of organic molecules onto inorganic supports, have been developed as a novel and hopeful class of hybrid sensing probes. The hybrid silica-magnetic based sensors provide perfect properties for production of various devices in sensing technology. The hybridization of silica and magnetic NPs as biocompatible, biodegradable and s...

[ 25 ] - Comparison of liposomal formulations incorporating BMP-2 peptide to induce bone tissue engineering

Objective(s): Fabricating a biomimetic scaffold platform combined with controlled release of bioactive agents is a practical approach for bone tissue engineering. Controlled delivery of peptides and growth factors which play a significant role in osteogenesis is an important issue reducing the associated adverse effects and leading to cost-effectiveness. Materials and Methods: We develope...