Seyed Jalal Hosseinimehr

[ 1 ] - Effect of Malva sylvestris cream on burn injury and wounds in rats

Objectives: Burn injury is one of the most health-threatening problems in the world. Malva sylvestris (M. sylvestris) flowershave a high mucilage content and are used as a remedy for cut wound and dermal infected wounds in Iranian folklore Medicine. The purpose of this study was to investigate the effect of M. sylvestris cream on the second degree burn injury in rats. Materials and Methods: Fiv...

[ 2 ] - Zataria multiflora ameliorates cisplatin-induced testicular damage via suppression of oxidative stress and apoptosis in a mice model

Objective(s): Cisplatin (CP), as an anti-neoplastic drug, causes testicular damage. Zataria multiﬂora Boiss (ZM), a medicinal plant, has antioxidant and anti-inflammatory properties. The aim of this study was to investigate the effects of ZM against CP-induced testicular toxicity. Materials and Methods: In this experimental study, thirty-two adult male mice were randomly divided into four group...

[ 3 ] - 99mTc-Glucarate for assessment of paclitaxel therapy in human ovarian cancer in mice

Objectives: The monitoring of cancer treatment response to chemotherapy is considered an essential strategy for follow-up of patients. The aim of this study was to evaluate the use of 99mTc-glucarate as a radiotracer for in vivo quantification and visualization of necrotic area and therapeutic effect of paclitaxel in ovarian cancer xenografted nude mice. Materials and Methods: After implantatio...

[ 4 ] - Radioprotective effect of thymol against salivary glands dysfunction induced by ionizing radiation in rats

The aim of this study was to investigate the radioprotective effect of thymol as a natural product against salivary glands dysfunction induced by ionizing radiation in rats. The rats were treated with thymol at dose of 50 mg/Kg before exposure to radiation at dose 15Gy. Salivary gland function was evaluated with radioisotope scintigraphy and then salivary gland to background counts ratio was ca...

[ 5 ] - Radioprotective effect of thymol against salivary glands dysfunction induced by ionizing radiation in rats

The aim of this study was to investigate the radioprotective effect of thymol as a natural product against salivary glands dysfunction induced by ionizing radiation in rats. The rats were treated with thymol at dose of 50 mg/Kg before exposure to radiation at dose 15Gy. Salivary gland function was evaluated with radioisotope scintigraphy and then salivary gland to background counts ratio was ca...

[ 6 ] - بررسی درمان زخم سوختگی بر مبنای طب سنتی مردمی و شفاهی از طریق عطاری‌های استان مازندران

مقدمه: آسیب‌های سوختگی در کشور‌های در حال توسعه یک مشکل اساسی می‌باشد. هدف از این مطالعه تعیین درمان‌های گیاهی‌، حیوانی و معدنی زخم‌های سوختگی بر مبنای طب سنتی سینه به سینه توسط عطاران و فروشندگان دارو‌های گیاهی در استان مازندران و عوامل مرتبط با آن بوده است. روش بررسی: این مطالعه مقطعی توصیفی است. جامعه مورد مطالعه ما کلیه عطاران و یا فروشندگان داروهای گیاهی استان مازندران بوده و با استفاده ا...

[ 7 ] - بررسی اثر سمی نانوذره سریم اکساید بر بیضه موش

Background and purpose: Cerium oxide nanoparticles (CNPs) are widely used as a catalyst in industry and as an antioxidant in applied nanomedicine. The biological effect of CNPs exposure on testis tissue is not known. The objective of this study was to evaluate the effect of CNPs on testis in mice model. Materials and methods: In this experimental study, CNPs were administered intraperitoneally...

[ 8 ] - بررسی اثر عصاره دانه گیاه کاسنی (Cichorium intybus L.) روی سمیت سلولی ناشی از بلئومایسین در سلول های نرمال و سرطانی

Background and purpose: Bleomycin as an anticancer drug causes side effects on normal tissues. The aim of this study was to investigate the effect of methanolic extract of Cichorium intybus seed (CI) on antiproliferative activity of bleomycin on human non-malignant skin and ovarian cancer cells. Materials and methods: Human non-malignant fibroblast cells (HFFF2) and ovarian cancer cells (SKOV-...

[ 9 ] - بررسی مفردات دارویی مؤثر بر سوختگی بر مبنای طب سنتی مکتوب ایران

Background and purpose: Burn is an important life-threatening disturbance for human. The purpose of this study was reviewing natural products recommended by resources of Iranian traditional medicine (ITM) for treatment of burn. Materials and methods: We investigated the books of philosophers of Iranian traditional medicine written sources from the 9th century AD with the words of "Hergh" and "...

[ 10 ] - فراورده های طبیعی با قابلیت محافظت پرتوی

Since exposure to irradiation in radiotherapy or unwanted radiation, induces side effects to health, it is important to makear effort to protect humans against side effects induced by irradiation. In these cases, radioprotective drugs could be used to reduce or delay the side effects and the mortality induced by irradiation. Although, thiol compounds were early compounds in these categories, ...

[ 11 ] - Synergistic effect of Achillea millefolium L. combined with bleomycin on prostate cancer cell

Background: The aim of this study was to investigate the effect of methanolic extract of Achillea millefolium L. (MEA) on the antiproliferative activity of bleomycin on human prostate cancer and normal skin cells. Materials and Methods: Human prostate cancer cell (DU-145) and human non-malignant fibroblast cell (HFFF2) were treated with MEA at various concentrations ( 20, 100, 500, 1000 and ...

[ 12 ] - Epicatechin enhances anti-proliferative effect of bleomycin in ovarian cancer cell

Background: Bleomycin (BLM) is an anti-cancer drug widely used in the treatment of cancer. BLM causes several side effects related to DNA and cellular damage. The aim of this study was investigated the effects of tea polyphenol epicatechin on anti-proliferative effects induced by bleomycin in human normal skin and human ovarian cancer cells. Materials and Methods: Human ovarian cancer cell (SK...

[ 13 ] - The Healing Effect of Arnebia Euchroma Ointment versus Silver Sulfadiazine on Burn Wounds in Rat

Background Burn is still a majordevastating condition in emergency medicine departments among both genders and all age groups in all developed and developing countries, leading to physical, psychological scars and economical burden. The present study aimed to determine the healing effect of topical treatment with Arnebia euchroma on second-degree burn wound in rats. Methods Fifty rats were ...

[ 14 ] - Atorvastatin Sensitizes Breast and Lung Cancer Cells to Ionizing Radiation

Tumour cells may be resistant to radiotherapy that results in unsuccessful cancer treatment in patients. The aim of this study was to evaluate the sensitizing effect of atorvastatin (ATV) on breast cancer (MDA-MB-231) and non-small cell lung cancer (A-549) cells following exposure to ionizing radiation (IR). These cells were treated with ATV and exposed to X-ray at dose 4 Gy. The radiosensitizi...

[ 15 ] - Atorvastatin Sensitizes Breast and Lung Cancer Cells to Ionizing Radiation

Tumour cells may be resistant to radiotherapy that results in unsuccessful cancer treatment in patients. The aim of this study was to evaluate the sensitizing effect of atorvastatin (ATV) on breast cancer (MDA-MB-231) and non-small cell lung cancer (A-549) cells following exposure to ionizing radiation (IR). These cells were treated with ATV and exposed to X-ray at dose 4 Gy. The radiosensitizi...

[ 16 ] - Effect of a Herbal Medicine Containing Satureja hortensis L., Hypericum perforatum L. and Foeniculum vulgare L. on Patients with COVID-19 Infection

Background and purpose: This research aimed at investigating the effect of herbal medicine on reduction of pulmonary complications in patients with Coronavirus disease 2019 (COVID-19). Materials and methods: Forty patients with COVID-19 infection older than 18 years of age (60% men) with the average age of over 55 years old enrolled in this study. Written consent was obtained and participants...