Bahareh Amin

[ 1 ] - Evaluation of the antidepressant-like effects of acute and sub-acute administration of crocin and crocetin in mice

Objective: The present study was designed to investigate the putative antidepressant effects of crocin and crocetin, two major active ingredients of Crocus sativus L. (saffron) using mice in two different regimens of acute and sub-acute administration. Material and Methods: In acute treatment, antidepressant-like activities of crocin and crocetin (10, 20 and 40 mg/kg, i.p.) were evaluated using...

[ 2 ] - Repeated systemic administration of the cinnamon essential oil possesses anti-anxiety and anti-depressant activities in mice

Objective(s): The present study aimed to evaluate the putative antidepressant and anti-anxiety effects of the cinnamon essential oil when administered acute (for 3 doses) and sub-acute (for 14 days) to mice. Materials and Methods: In an acute experimental study, forced swim test (FST) was conducted to evaluate the antidepressant-like behavior of animals treated with the intraperitoneal (IP) ess...

[ 3 ] - Enhancement of Antinociceptive Effect by Co-administration of Amitriptyline and Crocus sativus in a Rat Model of Neuropathic Pain

The aim of this study was to evaluate the anti-nociceptive effects of a low, sub-effective dose of amitriptyline, in combination with the different doses of ethanolic and aqueous extracts of Crocus sativus following sciatic nerve chronic constriction injury (CCI) in rats. Amitriptyline (3, 10 and 30 mg/kg, i.p.) and the extracts (25, 50 and 100 mg/kg, i.p.), were separately administered at the ...

[ 4 ] - Enhancement of Antinociceptive Effect by Co-administration of Amitriptyline and Crocus sativus in a Rat Model of Neuropathic Pain

The aim of this study was to evaluate the anti-nociceptive effects of a low, sub-effective dose of amitriptyline, in combination with the different doses of ethanolic and aqueous extracts of Crocus sativus following sciatic nerve chronic constriction injury (CCI) in rats. Amitriptyline (3, 10 and 30 mg/kg, i.p.) and the extracts (25, 50 and 100 mg/kg, i.p.), were separately administered at the ...

[ 5 ] - نقش سلول‌های گلیا در ایجاد دردهای نوروپاتی و بروز پدیده تحمل / پردردی اپیوئیدها

Common cellular and molecular mechanisms are not only involved in the development of neuropathic pain caused by neurological damage but also in the occurrence of the tolerance/hyperalgesia phenomenon caused by chronic use of opioids. It seems that the activation of the neuroimmune system in the brain and spinal cord is one of the most important mechanisms involved in the initiation and mainte...

[ 6 ] - تاثیر آمبلی‌پرنین بر علائم رفتاری درد نوروپاتی در مدل نوروپاتی بستن مزمن عصب سیاتیک (CCI) در موش صحرایی نر بالغ

سابقه و هدف: درد‌های مزمن و نوروپاتی که در اثر آسیب یا اختلال در عملکرد سیستم حسی پیکری ایجاد می‌شود، یکی از مشکلات بهداشتی مهم بوده و افراد زیادی از این بیماری رنج می‌برند. هدف از این مطالعه بررسی اثر آمبلی‌پرنین بر علائم رفتاری درد نوروپاتی در مدل نوروپاتی بستن مزمن عصب سیاتیک (CCI) در موش صحرایی نر بالغ بود.مواد و روش‌ها: تعداد 24 موش صحرایی نر نژاد ویستار (250±20 گرم) به صورت تصادفی به 3 گر...

[ 7 ] - Clavulanic acid improves ethanol withdrawal symptoms in rats

Objective(s): Ethanol withdrawal following chronic use, is an important challenge clinically. In this study, the effect of clavulanic acid was evaluated on the symptoms of ethanol withdrawal in rats. Materials and Methods: Alcohol dependence was induced by the gavage of ethanol (10% v/v, 2 g/kg), twice daily for 10 days. Clavulanic acid ...