Farzaneh Vafaee
Neurogenic Inflammation Research Center & Department of Physiology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
[ 1 ] - The effects of different fractions of Coriandrum sativum on pentylenetetrazole-induced seizures and brain tissues oxidative damage in rats
Objective: In the present work, the effects of different fractions of Coriandrum sativum (C. sativum), on pentylenetetrazole (PTZ)-induced seizures and brain tissues oxidative damage were investigated in rats. Materials and Methods: The rats were divided into the following groups: (1) vehicle, (2) PTZ (90 mg/kg), (3) water fraction (WF) of C. sativum (25 and 100 mg/kg), (4) n-butanol fraction (...
[ 2 ] - The Effects of Nigella Sativa Hydro-alcoholic Extract on Memory and Brain Tissues Oxidative Damage after Repeated Seizures in Rats
Regarding the therapeutic properties of Nigella sativa (NS), the effects of the plant hydro – alcoholic extract on learning, memory and brain tissues oxidative damage were investigated in penthylenetetrazole (PTZ) - induced repeated seizures.There were 4 experimental groups including: 1- control group; received saline, 2- PTZ group ; received saline and PTZ (50 mg/kg, i.p) , 3-PTZ- NS 200 and 4...
[ 3 ] - The Effects of Nigella Sativa Hydro-alcoholic Extract on Memory and Brain Tissues Oxidative Damage after Repeated Seizures in Rats
Regarding the therapeutic properties of Nigella sativa (NS), the effects of the plant hydro – alcoholic extract on learning, memory and brain tissues oxidative damage were investigated in penthylenetetrazole (PTZ) - induced repeated seizures.There were 4 experimental groups including: 1- control group; received saline, 2- PTZ group ; received saline and PTZ (50 mg/kg, i.p) , 3-PTZ- NS 200 and 4...
[ 4 ] - P84: Effect of Insulin-Like Growth Factor 2 (IGF2) as a Microglia-Derived Anti-Iinflammatory Ccytokine on Improving Memory Impairment Following Hippocampal Intracerebral Hemorrhage in Rat
Insulin-like growth factor 2 (IGF2) as a microglia-derived anti-inflammatory cytokine has a pivotal activity in memory consolidation. However, there is limited evidence on brain cell-originated IGF2 expression, regulation and function in pathological condition and neuro-inflammation. Hence, the present study was conducted to investigate the effect of IGF2 on improving the memory impairment in a...
[ 5 ] - Nepeta Dschuparensis Bornm Extract Moderates COX-2 and IL-1β Proteins in a Rat Model of Cerebral Ischemia
Background: Nepeta dschuparensis Bornm (NP) is used as a medicinal herb in Iran. In traditional medicine, this herb is extensively employed for curing ailments such as cardiovascular diseases. NP has antioxidant and anti-inflammatory properties. This project examined the effects of the NP extract on cyclooxygenase-2 (COX-2) and interleukin-1β (IL-1β) protein levels and its efficacy in neuroprot...
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