Fatemeh Ayoobi
Department of Physiology, Medical School, Rafsanjan University of Medical Sciences, Rafsanjan, Iran
[ 1 ] - Ginger extract modulates the expression of IL-12 and TGF-β in the central nervous system and serum of mice with experimental autoimmune encephalomyelitis
Objective: The main function of IL-12 is differentiation of naive T cells intoTh1 cells and TGF-β is a powerful immunoregulatory cytokine. The immunomodulatory and anti-inflammatory properties of ginger have also been reported in some studies. The aim of this study was to evaluate the effects of ginger extract on the expression of IL-12 and TGF-β in a model of experimental autoimmune encephalom...
[ 2 ] - The effect of Zataria multiflora Boiss hydroalcoholic extract and fractions in pentylenetetrazole-induced kindling in mice
Objective: At present, there are many antiepileptic drugs with a wide range of side effects on the human body. It was assumed that Zataria multiflora Boiss (Z. multiflora) with sedative, anti-spasmodic and anti-inflammatory activity may be effective in the treatment of epilepsy. The aim of the present study was to elucidate the effect of Z. multiflora hydroalcoholic extract and its fraction ext...
[ 3 ] - اثر متفورمین بر یادگیری لمسی و رفتار شبه اضطرابی در موش سوری اوارکتومی شده
Introduction: Estrogen regulates many processes in the brain such as synaptic formation, learning, and memory. Empirical evidence shows that there is a correlation among menopause, memory impairment, and anxiety due to Estrogen deficiency. In this study, we tested the effect of Metformin (Met) with antioxidant effect, which can improve the impairment of tactile learning and anxiety-like behavio...
[ 4 ] - Effect of the hydroalcoholic extract of pistachio on avoidance learning in male Wistar rats
Background: Pistachio is a plant that has long been cultivated in different parts of Iran. Pistachios are very nutritious and contain vitamins E and B, flavonoids, antioxidants, and carotenoids. Since the pistachio is effective in the treatment of some neurological disorders and is indigenous to Iran and considering the substantial use of this nut, it is necessary to investigate its effects on ...
[ 5 ] - بررسی اثر عصاره آبی- الکلی برگ گیاه کلپوره بر مسمومیت کلیوی ناشی از کلرید
زمینه و هدف: ترکیبات آنتی اکسیدانی موجود در گیاهان دارویی نماینده های مناسبی برای حفاظت در برابر مسمومیت ناشی از آلاینده های صنعتی هستند. در تحقیق حاضر اثر حفاظتی عصاره آبی الکلی برگ گیاه کلپوره (Teucrium polium) بر مسمومیت کلیوی ناشی از کلرید جیوه ارزیابی گردید. روش بررسی: در این مطالعه تجربی از 28 سر موش سوری نر استفاده شد. حیوانات به طور تصادفی در 4 گروه شاهد، گروه دریافت کننده کلرید جیوه، گ...
[ 6 ] - بررسی اثرات عصاره متانولی دانه گیاه رازیانه در مدل پارکینسونی ایجادشده توسط تزریق داخل بطنی 6-هیدروکسی دوپامین در موش‌های صحرایی ماده، با استفاده از آزمون‌های رفتاری
Background and Aim: Oxidative stresses are involved in neuronal degeneration of substantia nigra and thereby induction of Parkinson's disease. It is reported that Foeniculum Vulgare L. can affect lactating and modulating dopaminergic system activity and antioxidant activity as well. In the present study, the effects of methanolic extract of Foeniculum Vulgare seeds on a Parkinson’s disease mode...