Ali Akbar Oroojan
Department of Physiology, Student Research Committee, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
[ 1 ] - Antidiabetic, hypolipidemic and hepatoprotective effects of Arctium lappa root’s hydro-alcoholic extract on nicotinamide-streptozotocin induced type 2 model of diabetes in male mice
Objective: Arctium lappa (burdock), (A. lappa) root has hypoglycemic and antioxidative effects, and has been used for treatment of diabetes in tradition medicine. This study was conducted to evaluate the antidiabetic and hypolipidemic properties of A. lappa root extract on nicotinamide-streptozotocin (NA-STZ)-induced type2 diabetes in mice.Materials and Methods: In this investigation, 70 adult ...
[ 2 ] - Protective effect of metformin on toxicity of butyric acid and arsenic in isolated liver mitochondria and langerhans islets in male mice: an in vitro study
Objective(s): Arsenic, a toxic metal in drinking water and butyric acid (BA) is a free fatty acid found in many foods. These two can induce oxidative stress in some tissues. The present study investigated the protective effect of metformin against toxicity induced by Arsenic (As) and BA in isolated mice liver mitochondria and pancreatic islets. Materials and Methods: In this study, liver mitoch...
[ 3 ] - Evaluation of Diabetogenic Mechanism of High Fat Diet in Combination with Arsenic Exposure in Male Mice
Obesity is a main reason of type 2 diabetes and also chronic exposure to arsenic (As)can produce diabetic symptoms. In previous studies, the association between high-fat dietand arsenic in the incidence of diabetes was found, but the role of beta cells activity, livermitochondrial oxidative stress, and hepatic enzymes (leptin, adiponectin and beta amylase)was unclear. Thus, present study was co...
[ 4 ] - Evaluation of Diabetogenic Mechanism of High Fat Diet in Combination with Arsenic Exposure in Male Mice
Obesity is a main reason of type 2 diabetes and also chronic exposure to arsenic (As)can produce diabetic symptoms. In previous studies, the association between high-fat dietand arsenic in the incidence of diabetes was found, but the role of beta cells activity, livermitochondrial oxidative stress, and hepatic enzymes (leptin, adiponectin and beta amylase)was unclear. Thus, present study was co...
[ 5 ] - بررسی اثر عصاره آبی و آبی‌الکلی دانه زیره سیاه (Bunium persicum) بر میزان ترشح انسولین از جزایر لانگرهانس جداشده موش سوری نر
Background & Aims: As B. persicum is used in treatment of diabetes, we aimed to study the effect of B. persicum seeds extract on level of insulin secretion from isolated islets of langerhans in male mouse.Materials & Methods: In this experimental study, adult male mice (NMARI) weighting 20-25g were purchased. Islets of langerhans were isolated by collagenase digestion method and were divided i...
[ 6 ] - بررسی سطح پلاسمایی ویتامین D در مبتلایان به ژیاردیازیس مزمن مراجعه کننده به آزمایشگاه بیمارستان‌های آموزشی دانشگاه علوم پزشکی جندی شاپور اهواز و احتمال خطر ابتلاء به دیابت نوع 2 در این افراد
زمینه و هدف: ژیاردیازیس یک بیماری انگلی ایجاد توسط ژیاردیا لامبلیا است که باعث سوء جذب ویتامین Dشده و کمبود این ویتامین احتمال ابتلا به دیابت نوع2 را افزایش می دهد. بنابراین مطالعه حاضر با هدف بررسی اثر ژیاردیازیس مزمن بر وضعیت ویتامینD و خطر ابتلاء به دیابت نوع 2 در بیماران صورت پذیرفت. روش بررسی: در مطالعه مورد شاهدی(Case-Control) حاضر تعداد 60 نفراز مراجعین به آزمایشگاه بیمارستان های آ...
[ 7 ] - Efficiency of naringin against reproductive toxicity and testicular damages induced by bisphenol A in rats
Objective(s): Bisphenol A (BPA) as a synthetic compound is applied in many plastic industries. BPA has been reported to have endocrine-disrupting feature with cytotoxic effects. The study aimed to evaluate the efficiency of Naringin against testicular toxicity induced by BPA in adult rats.Materials and Methods: The animals were assigned into six groups of control, BPA-treated (50 mg/kg), BPA+Na...
[ 8 ] - Antioxidant, anti-apoptotic, and protective effects of myricitrin and its solid lipid nanoparticle on streptozotocin-nicotinamide-induced diabetic nephropathy in type 2 diabetic male mice
Objective(s): The present study evaluates the protective effects of myricitrin and its solid lipid nanoparticle (SLN) on diabetic nephropathy (DN) induced by streptozotocin-nicotinamide (STZ-NA) in mice. Materials and Methods: In this experimental study, 108 adult male NMRI mice were divided into 9 groups: control, vehicle, diabetes, dia...
[ 9 ] - COVID-19: a hypothesis to prevent SARS-CoV-2 from entering respiratory cells
Coronaviruses (CoVs) are a group of viruses that induce infection in the respiratory and other systems in the human body. There are two coronaviruses that transmitted from animals to humans including severe acute respiratory syndrome (SARS) and the Middle East respiratory syndrome (MERS) (1). The novel coronavirus that appeared at first in Wuhan, China, in December 2019 was named as severe acut...
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