Akram Ahangarpour
Health Research Institute, Diabetes Research Center, Department of Physiology, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
[ 1 ] - Antidiabetic, hypolipidemic and hepatoprotective effects of Arctium lappa root’s hydro-alcoholic extract on nicotinamide-streptozotocin induced type 2 model of diabetes in male mice
Objective: Arctium lappa (burdock), (A. lappa) root has hypoglycemic and antioxidative effects, and has been used for treatment of diabetes in tradition medicine. This study was conducted to evaluate the antidiabetic and hypolipidemic properties of A. lappa root extract on nicotinamide-streptozotocin (NA-STZ)-induced type2 diabetes in mice.Materials and Methods: In this investigation, 70 adult ...
[ 2 ] - The effect of hydro-alcoholic celery (Apium graveolens) leaf extract on cardiovascular parameters and lipid profile in animal model of hypertension induced by fructose
Objectives:Hypertension is one of the most common diseases of the modern era. This study evaluates the effect of hydro-alcoholic celery leaf extract onsystolic blood pressure (SBP), heart rate (HR) and lipid profile in animals’ model of hypertension induced by fructose. Materials and Methods: Sprague Dawley rats were divided into five groups: 1) control group (free access to tap drinking water)...
[ 3 ] - Evaluation of Diabetogenic Mechanism of High Fat Diet in Combination with Arsenic Exposure in Male Mice
Obesity is a main reason of type 2 diabetes and also chronic exposure to arsenic (As)can produce diabetic symptoms. In previous studies, the association between high-fat dietand arsenic in the incidence of diabetes was found, but the role of beta cells activity, livermitochondrial oxidative stress, and hepatic enzymes (leptin, adiponectin and beta amylase)was unclear. Thus, present study was co...
[ 4 ] - Progesterone and Cilostazol Protect mice pancreatic islets from oxidative stress induced by hydrogen peroxide
Abstract Reactive oxygen species and oxidative stress impair β-cell function and reduce insulin secretion. It has been shown that progesterone and cilostazol possess antioxidant properties. The present study was aimed to investigate in vitro pretreatment effect of progesterone and cilostazol on insulin secretion as well as their protective effects against hydrogen peroxide-induced oxidative str...
[ 5 ] - Effects of hydro-alcoholic extract of Vitex agnus-castus fruit on kidney of D-galactose-induced aging model in female mice
The aim of the present study was to evaluate the effect of a hydro-alcoholic extract of Vitex agnus-castus (VAC) fruit on blood urea nitrogen (BUN), creatinine (Cr) and, kidney histology of a female mouse model of D-galactose induced aging. In this experimental study, 72 NMRI mice were divided into 6 groups: control, VAC, D-galactose, D-galactose+VAC, aging, and aging+VAC. D-galactose was injec...
[ 6 ] - Evaluation of Diabetogenic Mechanism of High Fat Diet in Combination with Arsenic Exposure in Male Mice
Obesity is a main reason of type 2 diabetes and also chronic exposure to arsenic (As)can produce diabetic symptoms. In previous studies, the association between high-fat dietand arsenic in the incidence of diabetes was found, but the role of beta cells activity, livermitochondrial oxidative stress, and hepatic enzymes (leptin, adiponectin and beta amylase)was unclear. Thus, present study was co...
[ 7 ] - Progesterone and Cilostazol Protect mice pancreatic islets from oxidative stress induced by hydrogen peroxide
Abstract Reactive oxygen species and oxidative stress impair β-cell function and reduce insulin secretion. It has been shown that progesterone and cilostazol possess antioxidant properties. The present study was aimed to investigate in vitro pretreatment effect of progesterone and cilostazol on insulin secretion as well as their protective effects against hydrogen peroxide-induced oxidative str...
[ 8 ] - اثر گیاه کندر (Boswellia serrata) بر میزان قند، انسولین و مقاومت به انسولین در بیماران دیابتی نوع2
Background and Objective: Type 2 diabetes mellitus is characterized by a progressive decline in insulin action. Boswellia serrata administration during diabetes exerts beneficial effects in diabetic rats. The purpose of this study was to assess the effect of Boswellia serrata on blood glucose, insulin, insulin resistance index in type 2 diabetes patients. Materials and Methods: This...
[ 9 ] - اثر سولفید هیدروژن برون‌زاد و درون‌زاد بر سطح پلاسمایی رنین و اریتروپویتین در مسمومیت کلیوی ناشی از سیس‌پلاتین در موش صحرایی
Background & Aims: Hydrogen sulfide due to cytoprotective effects can be used in prevention and treatment of many disorders. The effects of hydrogen sulfide onhormonal system in rat kidneys with cisplatin (CP) nephrotoxicity are unknown. The purpose of the experiments was to survey the effects of hydrogen sulfide on rat kidneys hormonal system with cisplatin nephrotoxicity. Ma...
[ 10 ] - بررسی سطح پلاسمایی ویتامین D در مبتلایان به ژیاردیازیس مزمن مراجعه کننده به آزمایشگاه بیمارستان‌های آموزشی دانشگاه علوم پزشکی جندی شاپور اهواز و احتمال خطر ابتلاء به دیابت نوع 2 در این افراد
زمینه و هدف: ژیاردیازیس یک بیماری انگلی ایجاد توسط ژیاردیا لامبلیا است که باعث سوء جذب ویتامین Dشده و کمبود این ویتامین احتمال ابتلا به دیابت نوع2 را افزایش می دهد. بنابراین مطالعه حاضر با هدف بررسی اثر ژیاردیازیس مزمن بر وضعیت ویتامینD و خطر ابتلاء به دیابت نوع 2 در بیماران صورت پذیرفت. روش بررسی: در مطالعه مورد شاهدی(Case-Control) حاضر تعداد 60 نفراز مراجعین به آزمایشگاه بیمارستان های آ...
[ 11 ] - بررسی تاثیر 6 هفته تمرین هوازی تداومی بر سطوح مقاومت به انسولین، نیتریک اکساید و برخی از پروفایل های لیپیدی موش های نر دیابتی ویستار
مقدمه: دیابت یکی از بیماریهای مهم متابولیکی بوده که از پیامدهای آن، اختلال در عملکرد اندوتلیال است و فعالیت ورزشی مناسب به عنوان راه کاری غیر دارویی توصیه می شود. بنابراین هدف از پژوهش حاضر، بررسی تاثیر تمرین هوازی تداومی بر سطح سرمی نیتریک اکساید، مقاومت به انسولین و برخی از پروفایل های لیپیدی در موش های صحرایی نر دیابتی می باشد. مواد و روش ها: 60 سر موش صحرایی نر ویستار به صورت تصادفی ب...
[ 12 ] - اثر عصاره‌های آبیالکلی و آبیِ پوست و دانه و عصاره آبیالکلی پولپ هندوانه ابوجهل بر میزان گلوکز، انسولین و FIRI موش‌های صحرایی نرِ مقاوم به انسولین
اهداف: رایجترین کاربرد هندوانه ابوجهل در طب سنتی ایران، درمان دیابت و کاهش میزان قندخون است . با توجه به تاثیر فروکتوز در افزایش گلوکز و ایجاد مدل مقاوم به انسولین، این مطالعه با هدف مقایسه اثر عصاره قسمت‌های مختلف هندوانه ابوجهل بر موش‌های صحرایی نر مقاوم به انسولین انجام شد. روش‌ها: در مطالعه تجربی حاضر، 63 سر موش صحرایی نر بالغ ویستار استفاده شد. پس از ایجاد مدل مقاوم به انسولین به‌وسیله فر...
[ 13 ] - Efficiency of naringin against reproductive toxicity and testicular damages induced by bisphenol A in rats
Objective(s): Bisphenol A (BPA) as a synthetic compound is applied in many plastic industries. BPA has been reported to have endocrine-disrupting feature with cytotoxic effects. The study aimed to evaluate the efficiency of Naringin against testicular toxicity induced by BPA in adult rats.Materials and Methods: The animals were assigned into six groups of control, BPA-treated (50 mg/kg), BPA+Na...
[ 14 ] - Antioxidant, anti-apoptotic, and protective effects of myricitrin and its solid lipid nanoparticle on streptozotocin-nicotinamide-induced diabetic nephropathy in type 2 diabetic male mice
Objective(s): The present study evaluates the protective effects of myricitrin and its solid lipid nanoparticle (SLN) on diabetic nephropathy (DN) induced by streptozotocin-nicotinamide (STZ-NA) in mice. Materials and Methods: In this experimental study, 108 adult male NMRI mice were divided into 9 groups: control, vehicle, diabetes, dia...
[ 15 ] - Protective effects of gallic acid on cardiac electrophysiology and arrhythmias during reperfusion in diabetes
Objective(s): Gallic acid (GA), a potent anti-oxidant, plays an important role in reducing diabetic induced cardiac disorders. Therefore, the present investigation was purposed to determine the beneficial effect of GA in cardiac arrhythmias during reperfusion in diabetes induced by alloxan. Materials and Methods: Male Sprague-Dawley rats...
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