Sajad Sahab Negah

[ 1 ] - Curcumin attenuates harmful effects of arsenic on neural stem/progenitor cells

Objective: Arsenic, an environmental pollutant, decreases neuronal migration as well as cellular maturation and inhibits the proliferation of neural progenitor cells. Curcumin has been described as an antioxidant and neuroprotective agent with strong therapeutic potential in some neurological disorders. Human adipose-derived stem cells (hADSCs), a source of multipotent stem cells, can self-rene...

[ 2 ] - Survival, proliferation, and migration of human meningioma stem-like cells in a nanopeptide scaffold

Objective(s): In order to grow cells in a three-dimensional (3D) microenvironment, self-assembling peptides, such as PuraMatrix, have emerged with potential to mimic the extracellular matrix. The aim of the present study was to investigate the influence of the self-assembling peptide on the morphology, survival, proliferation rate, migration potential, and differentiation of human meningioma st...

[ 3 ] - The photoperiod and heat stress effects on histometrical structure of rat prostate gland

BACKGROUND: There is not enough information about theeffects of heat stress and photoperiod on different lobes structure.OBJECTIVES: The present study aims at determining thehistological changes and the rate of changes in each lobes of ratprostate, affected by photoperiod changes and heat stress.METHODS:To this end, 15 adult male wistar rats were divided tothree groups: 1. the control group in ...

[ 4 ] - O 8: Tenasin-C as a New Target for Multiple Sclerosis Treatment

Multiple Sclerosis (MS) is an autoimmune disease, which is characterized by demyelination and neuroinflammation. Extracellular Matrix (ECM) have important role in the central nervous system (CNS). Alterations are happening to the ECM after the CNS disorder like MS, Alzheimer and other neural injury. Tenasin-C (TnC) is a glycoprotein that is highly expressed in inflammatory conditions of the CNS...

[ 5 ] - P 41: Meningioma Stem Like Cells and Self Assembling Nanopeptide Scaffold for Treatment of Traumatic Brain Injury in Animal Model

Introduction: Brain injury is an important cause of morbidity and mortality worldwide and so far, there has been no absolute treatment for the damaged brain tissue. Using human stem cells with self-assembling scaffolds can be a promising method for treatment of traumatic brain injury. Materials and Methods: Human meningioma stem cells were isolated, cultured and then expanded into in vitro cond...

[ 6 ] - P 88: Matrix Metalloproteinases in Neuroinflammation

Matrix metalloproteinases (MMPs) are a family of neutral proteinases that are important in normal development, cellular differentiation or migration, angiogenesis, neurogenesis, wound repair, and a wide range of pathological processes such as oxidative stress and neuroinflammation. MMPs have been demonstrated to increase the permeability of the blood–brain barrier (BBB) by degrading the c...

[ 7 ] - P 99: Self-Assembling Peptide Scaffolds as New Therapeutic Method in TBI: Focused on Bioactive Motifs

Traumatic brain injury (TBI) is a common reason of brain tissue loss as a result of tumors, accidents, and surgeries. Renewal of the brain parenchyma is restricted by many reasons such as inimical substances produced as the result of trauma and also inflammatory responses. A strong cascade of inflammatory responses begins as a result of TBI which include recalling peripheral leukocytes into the...

[ 8 ] - P 100: Stem Cells as Neuroinflammatory Modulator in TBI: A Narrative Review

Traumatic brain injury (TBI) is physical damage to the brain structure which has a high global rate of mortality and morbidity. TBI can cause intense inflammatory response due to accumulation of leukocytes in cerebral matrix and activation of microglia. Microglia can differentiate into M1 macrophages or M2 macrophages following the changes in biochemical properties of brain tissue. M1 sub type ...

[ 9 ] - P 104: Effects of Human Neural Stem Cells in Cure Neuroinflammation of Traumatic Brain Injury

Traumatic brain injury (TBI) is defined as an external mechanical injury to the brain. Neuroinflammation plays a vital role in the pathophysiology of TBI. Microglia and astrocytes play a central role in the initiation and regulation of inflammation. Numerous pro-inflammatory mediators including cytokines, chemokines, reactive oxygen species (ROS) and nitric oxide (NO) released by microglia. In ...

[ 10 ] - P 117: Endocannabinoid System as a Novel Therapeutic Target in Epilepsy

Endocannabinoid (ECB) system plays a vital role in responses to stress. Moreover, ECB and its receptors cause anti-inflammatory, anti-oxidative and neuroprotective effects by modulating neuronal, glial and endothelial cell functions. A number of studies have demonstrated ECB system notably defects in neurotraumatic and neurodegenerative diseases like epilepsy, TBI, Alzheimer’s disease and...

[ 11 ] - P 140: Stem Cells in Multiple Sclerosis

Multiple sclerosis (MS) is an inflammatory disease of the central nervous system (CNS). Inflammation caused by immune cells destroy the myelin and then axon. CNS failure to complete repair results in permanent disabilities. Some types of stem cells have special potentials to repair these injuries and even cure MS. Neural crest stem cells with a mutual origin with CNS and the ability of differen...

[ 12 ] - P 141: Mesenchymal Stem Cells as Treatment in Neuroinflammatory Disease

Mesenchymal stem cells can be obtained from deferent tissues like adipose tissue, umbilical cord, placenta, skin, bone marrow, etc. These cells have regulatory effects on all types of immune cells such as dendritic cell, natural killers and lymphocytes. Mesenchymal stem cells induce inhibitory phenotypes of Antigen Presenting Cells (APCs) following their activity. They also change T cells pheno...

[ 13 ] - P 147: Role of Sparstolonin B in Intracerebral Hemorrhage-Induced Inflammatory Brain Injury: Blocking the Formation of TLR2/TLR4 Heterodimer

Intra-cerebral hemorrhage (ICH) is a particularly severe type of stroke accounting for 10–15 % of all strokes and is associated with a mortality rate of 30–50%. Neuroinflammation contributes to ICH-induced secondary brain injury and understanding the mechanisms causing neuroinflammation can be helpful to find new treatments of ICH. Recent studies demonstrated that toll like receptor...

[ 14 ] - P 148: The Role of Cannabinoids in Ischemia Stroke

Inflammation serves a protective function in controlling infections and promoting tissue repair, and can also cause damage to tissue and disease. Many types of cells involved in this process, expressing the components of the cannabinoid signaling system that can be controlled endogenously or pharmacologically. Cannabinoids inhibit neuroinflammation and the immune cells express the whole machi...

[ 15 ] - P 149: Effect of Glycoprotein IIb/IIIa Inhibition on Acute Ischemic Stroke Injuries

Ischemic stroke accounts for about 87 percent of all cases. It occurs as a result of an obstruction within a vessel of the brain and sudden loss of blood circulation to the corresponding area resulting in the loss of brain function. It is caused by thrombotic or embolic occlusion of an artery and is more common than hemorrhagic stroke. We know that most of the injuries after an acute ischemic s...

[ 16 ] - P 150: The Role of Blood Brain Barrier Restoration in the Multiple Sclerosis

Blood Brain Barrier (BBB) is a specialized non fenestrate barrier that formation by the endothelial cells and controls the transportation of the cells and molecules in to the brain. Reducing in function of BBB is one of disruptions in neurological diseases like multiple sclerosis. Endothelial progenitor cell (EPC) help to the BBB to control the diapedesis of inflammatory cells & molecules in to...

[ 17 ] - P 151: Clinical Trial in Cell Therapy of Multiple Sclerosis

Neuroinflammation is a disorder that causes neurological disease. Neuroinflammation has a significant role in induce of Multiple sclerosis (MS) and one of the situations that must be treated stops the ongoing process of inflammation against the CNS by self-reactive lymphocytes. According to the successful results that were obtained from the pre-clinical phase of cell therapy, many studies were ...

[ 18 ] - P 152: Mesenchymal Stem Cells as a Therapeutic Target in Multiple Sclerosis

Neuroinflammation has a significant role in induce of Multiple sclerosis (MS) many approaches have been used to treat MS, but none of these methods have not been able to fully improve. One of the methods can suppress inflammation and regenerate the nervous system is the use of cell therapy. Using cell therapy in pre-clinic phase can be realized, it's mechanism and potency to suppress neuroinfla...

[ 19 ] - بررسی تکثیر آستروسیت ‌های جدا شده از قشر مغز موش صحرایی در یک داربست نانوپپتید

مقدمه: آستروسیت ها فراوانترین سلول ها در مغز پستانداران هستند و نقش مهمی در تنظیم پیام رسانی عصبی، حفاظت سلول های عصبی و تعیین سرنوشت پیش‌سازهای عصبی ایفاء می کنند. آستروسیت‌ها یکی از بهترین نامزدها برای سلول درمانی می باشد. داربست های سه بعدی یک ماتریکس سنتتیک هستند که یک محیط سه بعدی زیست سازگار، زیست تخریب پذیر و غیر سمی برای انواع سلول ها فراهم می کنند. در مطالعۀ حاضر ما آستروسیت...

[ 20 ] - O18: Role of Adult Hippocampal Neurogenesis in Anxiety Disorders

Neurogenesis occurs throughout life in several regions of the brain. In this lecture, a new sight for the role of the dentate gyrus and adult hippocampal neurogenesis in anxiety disorders will be discussed. The region that has obtained the most attention for its involvement in the neurogenesis of affective and anxiety disorders are the hippocampal and dentate gyrus. Evidence strongly suggests t...

[ 21 ] - اثرات یک پپتید نانوفیبری خود ساختۀ حاوی موتیف لامینین بر روی بقاء و تکثیر سلول‌ های بنیادی عصبی جنینی موش صحرایی

مقدمه: مطالعات اخیر نقش‌های کلیدی توالی‌ها و موتیف‌های مختلف را در هدایت ماتریکس خارج سلولی نشان داده‌اند. فعالیت‌های بیولوژیکی مولکول‌های بزرگ می‌تواند توسط موتیف‌هایی از ماتریکس خارج سلولی تقلید شود. توالی‌های پپتیدی و موتیف‌های لامینین می‌توانند به زیست ‌مواد داربست‌ها متصل شوند، حفاظت مکانیکی سلول‌ها را بهبود بخشند، رشد سلول‌ها را افزایش دهند و منجر به تشکیل بافت ها شوند. مواد و روش‌ها: سل...

[ 22 ] - P5: The Role of Helmet in Bicycle Accidents

لطفاً به چکیده انگلیسی مراجعه شود.

[ 23 ] - P13: Sleepiness in Road Accidents

لطفاً به چکیده انگلیسی مراجعه شود.

[ 24 ] - P17: Road Safety Education for Children

لطفاً به چکیده انگلیسی مراجعه شود.

[ 25 ] - P18: Minor Head Trauma in Children

لطفاً به چکیده انگلیسی مراجعه شود.

[ 26 ] - P23: Child Safety Seat and Accident

لطفاً به چکیده انگلیسی مراجعه شود.

[ 27 ] - P1: Negative Television and Memory

According to reports about 30-thousand people spent watching television had the impact on their memory and recall that the results showed no differences between men and women. The people who watched less than an hour a day did better at every memory function. As these contributors watched negative political ads, physiological responses indicated that their body was reflexively preparing to move...

[ 28 ] - P2: Neocortex and Memory

The human prefrontal cortex differs from all other mammals: the seat of complex cognition, abstract thinking, planning and future forecasting, and behavioral inhibition. Using our prefrontal cortex is a significant energy drain on the body, so despite its impressive capabilities, it’s daily capacity is limited. Some researchers estimate a mere 2-3 hours per day of activity depletes the pr...

[ 29 ] - P8: Thalamic Damage and Memory

Memory is the cognitive ability that allows acquiring, store and recalling information. Anterior thalamic dysfunction creates memory deficits in rats and humans. Anterior thalamus forms a memory network in connection with the hippocampus. This connectivity profile proposes that ventrolateral and anterior thalamus may display a nexus between reminder and control functions, such as action or atte...

[ 30 ] - P11: The Effect of Flavonoids in Memory

Flavonoids may exert particularly powerful actions on mammalian cognition and may reverse age-related declines in memory and learning. Flavonoids can be modulated neuronal function and there by influencing memory, learning and cognitive function. Dietary supplementation with flavonoid-rich foods, such as blueberry, green tea and Ginkgo biloba lead to significant reversals of age-related deficit...

[ 31 ] - P16: The Effect of PTSD on Memory

Post-traumatic stress disorder (PTSD), panic disorder and phobia manifest in ways that are consistent with an uncontrollable state of fear. Impaired memory for elements of the traumatic experience is a core feature of PTSD, and clinical complaints of memory impairment for non-trauma-related stimuli are common. Several studies have documented generalized memory impairment among patients with com...

[ 32 ] - P20: The Role of Protein Kinases in Memory

When an experience is encrypted into a long-lasting memory, it is believed that specific sets of neurons in the brain of the animal undergo changes including the strengthening of preexisting synapses and the growth and maintenance of new synaptic connections. These activity-dependent synaptic changes appear to require the coordination of a variety of cellular processes in spatially separated ce...

[ 33 ] - W7: In Vitro Traumatic Brain Injury Models

لطفاً به چکیده انگلیسی مراجعه شود.

[ 34 ] - P63: Application of Nanofibrous Scaffolds with Biomolecules as a Promise Approach for Reconstruction of Peripheral Nerve Injury

لطفاً به چکیده انگلیسی مراجعه شود.

[ 35 ] - P4: Evaluation of Mice Sperm Fertility Quality in Voice-Induced Stress

Reports indicate that one of the causes of harmful to the genital system, especially the testes is stress. Result of damage to testicular quality certainly will affect the quality of sperm fertility. Stress could be created secondarily after some pathological conditions such as neurological diseases or environmental factors. One of the causes of stress could be scary voices, such as cat voice f...

[ 36 ] - P41: The Effects of Voice-Induced Stress on Mice Testes Parameters

Reports indicate that one of the causes of harmful to the genital system, especially the testes stress. Stress could be created secondarily after some pathological conditions such as neurological diseases or environmental factors. One of the causes of stress could be scary voices, such as cat voice for mice. In this study we aimed to investigate the testes parameters in the animals that were ex...

[ 37 ] - P139: Role of Dopamine Receptor D3 in Depression and Anxiety

Dopamine (DA) is one of the main catecholamines in the brain and is crucial for movement coordination, endocrine function, reward, mood, memory and emotions. The dopaminergic system is the primary therapeutic target in the treatment of Parkinson’s disease (PD), drug addiction and schizophrenia. Notwithstanding, dysfunction of central dopaminergic neurotransmission has also been associated to de...

[ 38 ] - P140: Lipopolysaccharide and BDNF in Anxiety and Depression

Brain derived neurotrophic factor (BDNF) is a neurotrophin acting at several levels in the brain. Additionally, BDNF was shown to be responsible for the survival, maintenance and growth of neurons. Also, BDNF plays an important role in synaptic plasticity and memory processes. In activity-dependent synaptic plasticity, BDNF enhances long-term potentiation (LTP) in the hippocampus but blocks the...

[ 39 ] - P141: Role of Dopamine in Anxiety Behavior

The mesolimbic dopamine (DA) system contains both D1-like and D2-like receptors, has been connected to control of locomotor behavior. An apparent role for D1 and D2 receptors throughout the mesolimbic system in the alteration of locomotor behavior has been demonstrated in pharmacological studies. The nucleus accumbens (NAc) is comprised of a core and a shell subregion, which is a component of t...

[ 40 ] - PuraMatrix hydrogel enhances the expression of motor neuron progenitor marker and improves adhesion and proliferation of motor neuron-like cells

Objective(s): Cell therapy has provided clinical applications to the treatment of motor neuron diseases. The current obstacle in stem cell therapy is to direct differentiation of stem cells into neurons in the neurodegenerative disorders. Biomaterial scaffolds can improve cell differentiation and are widely used in translational medicine and tissue engineering. The aim...