Hamid Reza Rahimi
Student Research Committee, Department of Modern Sciences & Technologies, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
[ 1 ] - Curcumin: Reintroduced Therapeutic Agent from Traditional Medicine for Alcoholic Liver Disease
Alcoholic liver disease (ALD) is the main cause of chronic liver disease across the world and can lead to fibrosis and cirrhosis. The etiopathogenesis of ALD is related to ethanol-induced oxidative stress, glutathione reduction, abnormal methionine metabolism, malnutrition, and production of endotoxins that activate Kupffer cells. Curcumin is an active ingredient of the rhizome of turmeric. The...
[ 2 ] - The effect of nano-curcumin on HbA1c, fasting blood glucose, and lipid profile in diabetic subjects: a randomized clinical trial
Objective: Diabetes mellitus is defined as a group of metabolic diseases characterized by hyperglycemia resulting from defects in insulin secretion, insulin action, or both or insulin resistance. Curcumin inhibits NF-κB signaling pathway. The aim of this study is evaluation of the effect of Nano-curcumin on HbA1C, fast blood glucose and lipid profile in diabetic patients. Materials and Methods:...
[ 3 ] - Novel delivery system for natural products: Nano-curcumin formulations
Objective: Curcumin is extracted from Curcuma longa and regulates the intracellular signal pathways which control the growth of cancerous cell, inflammation, invasion and apoptosis. Curcumin molecules have special intrinsic features that can target the intracellular enzymes, genome (DNA) and messengers (RNA). A wide range of studies have been conducted on the physicochemical traits and pharmaco...
[ 4 ] - The Antiviral Effects of Curcumin Nanomicelles on the Attachment and Entry of Hepatitis C Virus
Background and Aims: Hepatitis C virus (HCV) is a member of the Flaviviridae family, which causes approximately 500,000 deaths annually. HCV infection treatment is often associated with significant adverse effects. Curcumin is an active ingredient of turmeric which has therapeutic anti-inflammatory effects in many diseases including infectious ones. Although curcumin is not soluble in water, if...
[ 5 ] - An In vitro Study on Curcumin Delivery by Nano-Micelles for Esophageal Squamous Cell Carcinoma (KYSE-30)
Background: The incidence of esophageal squamous cell carcinoma (ESCC) is increasing, causing catastrophic health burdens on communities. Curcumin has shown promise as a therapeutic agent in the treatment of colon, colorectal, pancreatic, and esophageal cancers but it has very poor bioavailability. The application of nano-carriers as drug delivery systems increases curcumin's bioavailability. C...
[ 6 ] - The effects of curcumin on the prevention of atrial and ventricular arrhythmias and heart failure in patients with unstable angina: A randomized clinical trial
Objective: Inflammation along with oxidative stress has an important role in the pathophysiology of unstable angina which leads to acute myocardial infarction, arrhythmias and eventually heart failure. Curcumin has anti-inflammatory and anti-oxidant effects and thereby, it may reduce cardiovascular complications. This randomized controlled trial aimed to investigate the effects of curcumin on t...
[ 7 ] - بررسی تاثیر نانو ریزحباب‌‌ها بر بیان ژن p53، القائ آپوپتوز و مهار رشد سلولی سرطان سینه (4T1)
مقدمه سرطان سینه، شایع‌‌ترین سرطان در بین زنان است و میانگین سن ابتلا در کشور ایران پایین‌‌تر از میانگین جهانی است. امروزه استفاده از ترکیبات نانو به عنوان یکی از روش‌‌های درمان موثر سرطان تبدیل شده است. تحقیق حاضر برای اولین بار در ایران با هدف بررسی استفاده از آب حاوی نانو حباب اکسیژن با غلظت 98 درصد اکسیژن به عنوان مکمل درمانی در درمان سرطان سینه در موش می‌‌باشد. مواد و روش‌‌ها موش‌‌ها...
[ 8 ] - The effect of nanomicelle curcumin, sorafenib, and combination of the two on the cyclin D1 gene expression of the hepatocellular carcinoma cell line (HUH7)
Objective(s): Hepatocellular carcinoma (HCC) is one of the most significant health condition around the world. As the only curative therapies, liver transplantation and surgical resection are the clinical treatments of HCC. Due to the systemic toxicity and severe side effects of these treatments, it is vital to establish new therapeutic approaches. The present study ai...
[ 9 ] - بررسی اثرات نانو میکروحباب ها هوا و اکسیژن بر سمیت سلولی و القای آپوپتوز در سلولهای سرطانی کبد (رده Huh7)
مقدمه کارسینوم کبدی (کارسینوم هپاتوسلولار) یکی از شایع‌‌ترین سرطانهای دنیا است و سالانه حدود یک میلیون نفر به این بیماری مبتلا میشوند. فناوری نانو یکی از فناوری‌های پیشرو در سال های اخیر است که در بخش های کشاورزی، صنعت و سیستم</strong...
[ 10 ] - Evaluation of the Effect of Curcumin and Imatinib on BCR-ABL Expression Gene in Chronic Human k562 Cells
Background and Aims: Detection of overexpression in tumor-inhibiting genes provides valuable information for leukemia diagnosis and prognosis. Chronic myeloid leukemia (CML) is a stem cell disorder determined by a well-defined genetic anomaly involving BCR-ABL translocation in the Philadelphia chromosome. Curcumin is a chemo-preventive agent for the primary cancer targets, such as the breast, p...
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