Abbas Zare Mirakabadi
Department of Venomous Animals and Antivenom Production, Razi Vaccine and Serum Research Institute, Karaj, Iran(Agricultural Research, Education and Extension Organization( AREEO), Tehran, Iran)
[ 2 ] - Evaluation of Iranian Snake ‘Macrovipera lebetina’ Venom Cytotoxicity in Kidney Cell Line HEK-293
Background:Envenomation by Macrovipera lebetina (M. lebetina) is characterized by prominent local tissue damage, hemorrhage, abnormalities in the blood coagulation system, necrosis, and edema. However, the main cause of death after a bite by M. lebetina has been attributed to acute renal failure (ARF). It is unclear whether the venom components have a direct or indirect action in causing ARF. T...
[ 3 ] - Acute Effects of the Iranian Snake (Naja Naja Oxiana) Venom on Heart
The myocardial effect of snake venoms is considered as one of the most common pathogenesis in many cases of snake envenomation. This study was under taken to investigate the effects of snake (Naja naja oxiana) venom on cardiac function in experimental animals. The blood samples from all the rabbits were collected before venom injection and then 140 µg/kg venom of snake (Naja naja oxiana) was in...
[ 4 ] - Partial Purification and Characterization of Anticoagulant Factor from the Snake (Echis carinatus) Venom
Objective(s): Snake venoms contain complex mixture of proteins with biological activities. Some of these proteins affect blood coagulation and platelet function in different ways. Snake venom toxin may serve as a starting material for drug design to combat several pathophysiological problems such as cardiovascular disorders. In the present study, purification of anticoagulation facto...
[ 5 ] - Effect of crude Venom of Odonthobuthus doriae scorpion in cell culture using ion channel modulators
Scorpion venom toxicity is one of the major medical concerns from old years, due to its influence on human activities and health. From many years ago a lot of researches established to examine different aspects of venom toxicity and its effects on different organs. During these years researchers are doing more specific studies on the cytotoxicity of scorpion venom. In Iran, Odonthobuthus doriae...
[ 6 ] - Anticancer Activity a of Caspian Cobra (Naja naja oxiana) snake Venom in Human Cancer Cell Lines Via Induction of Apoptosis
Abstract Cancer is the leading cause of death worldwide. Current anticancer drugs involve various toxic side effects; efforts are ongoing to develop new anticancer agents especially from the screening of natural compounds. Present study investigated cytotoxic effects and mode of cell death induced by the Caspian cobra venom in some human cancer cell lines. Cytotoxic effects of snake venom toxin...
[ 7 ] - Cytotoxic Effect of Iranian Vipera Lebetina snake Venom on HUVEC Cells
Objective: Envenomation by heamotoxic snakes constituted a critical health occurrence in the world. Bleeding is the most sever consequence following snake bite with viperid and crothalid snakes. It is believed that the degradation of vascular membrane caused hemorrhage; in contrast, some suggested that direct cytotoxicity has role in endothelial cell disturbances. This study was to evaluate the...
[ 8 ] - Cytotoxicity of ICD-85 NPs on Human Cervical Carcinoma HeLa Cells through Caspase-8 Mediated Pathway
The biological application of nanoparticles (NPs) is a rapidly developing area of nanotechnology that raises new possibilities in the treatment of human cancers. The cytotoxicity was evaluated by MTT and LDH assays. The apoptotic effect of free ICD-85 and ICD-85 NPs on HeLa cells was assessed using caspase-8 colorimetric assay. The MTT assay showed that ICD-85 NPs could enhance the in-vitro cyt...
[ 9 ] - Effect of crude Venom of Odonthobuthus doriae scorpion in cell culture using ion channel modulators
Scorpion venom toxicity is one of the major medical concerns from old years, due to its influence on human activities and health. From many years ago a lot of researches established to examine different aspects of venom toxicity and its effects on different organs. During these years researchers are doing more specific studies on the cytotoxicity of scorpion venom. In Iran, Odonthobuthus doriae...
[ 10 ] - Anticancer Activity a of Caspian Cobra (Naja naja oxiana) snake Venom in Human Cancer Cell Lines Via Induction of Apoptosis
Abstract Cancer is the leading cause of death worldwide. Current anticancer drugs involve various toxic side effects; efforts are ongoing to develop new anticancer agents especially from the screening of natural compounds. Present study investigated cytotoxic effects and mode of cell death induced by the Caspian cobra venom in some human cancer cell lines. Cytotoxic effects of snake venom toxin...
[ 11 ] - Cytotoxic Effect of Iranian Vipera Lebetina snake Venom on HUVEC Cells
Objective: Envenomation by heamotoxic snakes constituted a critical health occurrence in the world. Bleeding is the most sever consequence following snake bite with viperid and crothalid snakes. It is believed that the degradation of vascular membrane caused hemorrhage; in contrast, some suggested that direct cytotoxicity has role in endothelial cell disturbances. This study was to evaluate the...
[ 12 ] - Cytotoxicity of ICD-85 NPs on Human Cervical Carcinoma HeLa Cells through Caspase-8 Mediated Pathway
The biological application of nanoparticles (NPs) is a rapidly developing area of nanotechnology that raises new possibilities in the treatment of human cancers. The cytotoxicity was evaluated by MTT and LDH assays. The apoptotic effect of free ICD-85 and ICD-85 NPs on HeLa cells was assessed using caspase-8 colorimetric assay. The MTT assay showed that ICD-85 NPs could enhance the in-vitro cyt...
[ 13 ] - Production of a Human Recombinant Polyclonal Fab Antivenom against Iranian Viper Echis carinatus
Venomous snakebite is a life-threatening injury in many tropical and subtropical areas including Iran. The gold standard treatment option for human envenomation is the use of antivenoms. Despite the unique effects of horse-derived antivenoms on the treatment of snakebite, they are not fully perfect and need improvements. In this study, human recombinant Fab fragment antivenom was produced in Ro...
[ 14 ] - Cytotoxic and Anticancer Effects of ICD-85 (Venom Derived Peptides) in Human Breast Adenocarcinoma and Normal Human Dermal Fibroblasts
ICD-85 (venom derived peptides) has anti-proliferative effect and anti-angiogenesis activity on cancer cells. This study was performed to test the effect of ICD-85, on Human breast adenocarcinoma (MCF-7) and normal Human Dermal Fibroblasts (HDF) cell lines. In this experimental study, Mitochondrial activity, Neutral red uptake, Lactate dehydrogenase (cell necrosis), and cell morphology we...
[ 15 ] - Cytotoxic and Anticancer Effects of ICD-85 (Venom Derived Peptides) in Human Breast Adenocarcinoma and Normal Human Dermal Fibroblasts
ICD-85 (venom derived peptides) has anti-proliferative effect and anti-angiogenesis activity on cancer cells. This study was performed to test the effect of ICD-85, on Human breast adenocarcinoma (MCF-7) and normal Human Dermal Fibroblasts (HDF) cell lines. In this experimental study, Mitochondrial activity, Neutral red uptake, Lactate dehydrogenase (cell necrosis), and cell morphology we...
[ 16 ] - تأثیر22هفته تمرین هوازی بر بیان اینترفرون گاما و زیر رده های لکوسیتی در روند تولید پادزهر
یکارگیری فعالیت های ورزشی به عنوان روش غیر دارویی می تواند در فرایند تولید پادزهر و حفظ و ارتقا سلامت دام نقش مهمّی را ایفا کند. هدف از پژوهش حاضر، بررسی اثرات تمرین هوازی بر بیان اینترفرون گاما و زیر رده های لکوسیتی در روند تولید پادزهر بود. بدین منظور، 10 رأس اسب نژاد مخلوط بالغ 8- 5 ساله با میانگین وزنی350-300 کیلوگرم در چرخه تولید پادزهر به صورت تصادفی به دو گروه زهر (V) و گروه زهر + تمرین (...
[ 17 ] - First Case Report of an Unusual Echis genus (Squamata: Ophidia: Viperidae) Body Pattern Design in Iran
Three families of venomous snakes exist in Iran including Viperidae, Elapidae, and Hydrophidae. Viperidae family is the only family with a widespread distribution. Saw-scaled vipers are important poisonous snakes in Asia and Africa. This name is given to this snake due to the presence of obliquely keeled and serrated lateral body scales. Distribution of this genera is mostly reported in t...
[ 19 ] - Characterizing and controlling the loading of Vipera albicornuta venom in chitosan nanoparticles as an adjuvant and vaccine delivery system
The aim of this study was designing and preparing the chitosan nanoparticles (CS-NPs) loading with snake (Vipera albicornuta) venom as well as evaluating the influence of different factors on the encapsulation efficiency (EE) and loading capacity (LC) of venom. The morphologies and characteristics of CS-NPs were determined by scanning electron microscopy (SEM), Fourier transform infrared spectr...
نویسندگان همکار