Zahra Mousavi
Department of Pharmacology-Toxicology, Faculty of Pharmacy, Pharmaceutical Sciences Branch, Islamic Azad University,Tehran, Iran
[ 1 ] - Comparison of the Modified QuEChERS Method and the Conventional Method of Extraction in Forensic Medicine to Detect Methadone in Post-Mortem Urine by GCMS
Background:Extraction of drugs is one of the biggest concerns and the most important part of preparation and determination in forensic medicine. The lack of an easy, efficient and fast extraction method is the most important and most difficult problem despite the development of forensic centers and their being equipped with new diagnostic devices. In the present study, a comparison was conducte...
[ 2 ] - Anti-inflammatory activity and chemical composition of Pycnocycla bashagardiana fruit’s essential oil in animal models
Objective(s): Pycnocycla bashagardiana is an endemic species found only in Iran. Due to the presence of myristicin as the major component of the fruit’s oil we were prompted to assess the antinociceptive and anti-inflammatory properties of P. bashagardiana fruit’s essential oil (PBFEO). Materials and Methods: The analgesic activities of PBFEO (100, 200, and 400 mg/kg, IP) were studied by hot-pl...
[ 3 ] - A Multi Residue GC-MS Method for Determination of 12 Pesticides in Cucumber
Cucumber is one of the main vegetables in Iranian food basket. A wide range of pesticides are used for crops protection during the cultivation of vegetables such as cucumber due to heavy pest infestation. Analysis of pesticide residues in food and other environmental commodities have become essential requirement for consumers, producers, and food quality control authorities. This study was aime...
[ 4 ] - Interaction between Cannabinoid Compounds and Capsazepine in Protection against Acute Pentylenetetrazole-induced Seizure in Mice
The pharmacological interaction between cannabinoidergic system and vanilloid type 1 (TRPV1) channels has been investigated in various conditions such as pain and anxiety. In some brain structure including hippocampus, CB1 and TRPV1 receptors coexist and their activation produces opposite effect on excitability of neurons. In this study, we tested the hypothesis that TRPV1 channel is involved i...
[ 5 ] - A Direct Comparison of Anti-ulcer Effects of Coenzyme Q10 and Vitamin C on Indomethacin-induced Gastric Ulcer in Rat: A Controlled Experimental Study
Introduction: Indomethacin increases generation of mitochondrial reactive oxygen species (ROS) which have a crucial role in the indomethacin-induced gastric ulcer. Coenzyme Q10 has an antioxidant activity on mitochondria and cell membranes and protects lipids from oxidation and is essential for stabilizing biological membranes. Superoxide dismutase (SOD) acts as one of the defense mechanisms ag...
[ 6 ] - Sports supplements and Anabolic Androgenic Steroids
Recently, the use of sport supplements has become so common among most athletes. These supplements may contain undeclared substances that are banned by such international authorities as WHO, IOC and WADA. The present study, thus, is aimed at examining the final sport supplement products in terms of banned substances and measuring the adulteration level in order to prove the safety of these prod...
[ 7 ] - An investigation on the lead and cadmium content of cosmetics and sanitary products- a case study of toothbrush
Accordingly, this study was conducted to investigate the concentration of lead and cadmium of different toothbrush brands. For this purpose, a total number of 20 toothbrushes from different brands were taken randomly. The concentration of lead and cadmium in the toothbrushes was then specified using Graphite furnace atomic absorption spectroscopy (GFAAS), model AAS 6200. The samples were prepar...
[ 8 ] - The Effect of Hydro-alcoholic Extract of Leaves of Vitex on the Gestation Indices of Male Rats
Background: Phytoestrogens are some plant compounds with estrogenic biological effects which are found in many nutritional sources as soybean, flaxseed, and sesame. Vitex agnus-castus, also called Vitex, owns phytoestrogen properties. Studies have shown that phytoestrogens have different impacts on the gestation process and reproduction indices. Objective: The present study was aimed to inves...
[ 9 ] - Comparison of MnO2 nanoparticles and microparticles distribution in CNS and muscle and effect on acute pain threshold in rats
Objective(s): Recently, applications of MnO2 nanoparticles and microparticles in industry, pharmacology, and medicine have considerably expanded. Mn distribution and clearance from brain and spinal cord tissue compared with muscle tissue of rats after single subcutaneous injection of nanoparticles and microparticle of MnO2. Pain sensory threshold of rat was evaluated as neurologic consequence...
[ 10 ] - A Multi Residue GC-MS Method for Determination of 12 Pesticides in Cucumber
Cucumber is one of the main vegetables in Iranian food basket. A wide range of pesticides are used for crops protection during the cultivation of vegetables such as cucumber due to heavy pest infestation. Analysis of pesticide residues in food and other environmental commodities have become essential requirement for consumers, producers, and food quality control authorities. This study was aime...
[ 11 ] - Interaction between Cannabinoid Compounds and Capsazepine in Protection against Acute Pentylenetetrazole-induced Seizure in Mice
The pharmacological interaction between cannabinoidergic system and vanilloid type 1 (TRPV1) channels has been investigated in various conditions such as pain and anxiety. In some brain structure including hippocampus, CB1 and TRPV1 receptors coexist and their activation produces opposite effect on excitability of neurons. In this study, we tested the hypothesis that TRPV1 channel is involved i...
[ 12 ] - اثرات حفاظتی کوئرستین در مقابل سمیت قلبی دوکسوروبیسین در موش صحرایی نر
سابقه و هدف: دوکسوروبیسین داروی ضد سرطان موثر از دسته آنتراسیکلینها است، گرچه به دلیل عوارض جانبی حاد و مزمن از جمله سمیت قلبی کاربرد بالینی آن محدود شده است. در این مطالعه اثر حفاظتی کوئرستین در سمیت قلبی ناشی از دوکسوروبیسین مورد بررسی قرار گرفت. روش بررسی: در این مطالعه تجربی، موش های ویستار در 5 گروه (هر گروه 6موش) استفاده شدند. در یک گروه کنترل، موشهای صحرایی محلول سالین(mL/kg1) و در گرو...
[ 13 ] - Effects of Enoxaparin Emulsion on Dimethylbenzanthracene-induced Breast Cancer in Female Rats
Background : Enoxaparin is an anticoagulant medication. Anticoagulation inhibits tumor cell–mediated release of angiogenic proteins and diminishes angiogenic response. Angiogenesis is an important event in various cancers such as breast cancer. Angiogenesis provide oxygen and nutrients to tumor cells and causes tumor progression. The aim of the present study was to evaluate the anti-angio...
[ 14 ] - A New Potentiometric Sensor for Determination and Screening Phenylalanine in Blood Serum Based on Molecularly Imprinted Polymer
Methods routinely utilized for detection of phenylalanine in new-born blood consist of enzymatic assays, lacking sensitivity and HPLC assays which are expensive and time-consuming to conduct. We, here, report for the first time, the construction of a phenylalanine sensitive electrode, on the basis of a selective molecularly imprinted polymer, offering sensitivity, economy and ease of use for th...
[ 15 ] - A New Potentiometric Sensor for Determination and Screening Phenylalanine in Blood Serum Based on Molecularly Imprinted Polymer
Methods routinely utilized for detection of phenylalanine in new-born blood consist of enzymatic assays, lacking sensitivity and HPLC assays which are expensive and time-consuming to conduct. We, here, report for the first time, the construction of a phenylalanine sensitive electrode, on the basis of a selective molecularly imprinted polymer, offering sensitivity, economy and ease of use for th...
[ 16 ] - بررسی علل و شیوع مسمومیت با دیگوکسین در بیماران قلبی بستری در بیمارستان فیروزگر تهران در طی سالهای 1394- 1390
زمینه و هدف : داروی دیگوکسین به وفور برای بیماران قلبی تجویز می شود و اوردوز اتفاقی بویژه در صورت بروز نارسایی کلیوی یا در نتیجه تداخلات داروی در این بیماران بصورت شایع رخ میدهد. هدف از این مطالعه، بررسی رابطۀ سطح سرمی دیگوکسین با علائم مسمومیت، تعیین نقش فاکتورهای مداخلهکننده مانند بیماریهای زمینهای، اختلالات الکترولیتی و متابولیک در رابطه با بروز مسمومیت و تعیین شیوع علائم قلبی و غیر قلبیِ ...
[ 17 ] - اثر ضد درد روغن دانههای مریم گلی جنوبی (Salvia sharifii Rech. F. & Esfand) در آزمون فرمالین در موش سوری نر
سابقه و هدف: مریم گلی جنوبی (Salvia sharifii Rech. F. & Esfand) از خانوادهLamiaceae به عنوان یک گیاه دارویی، کاربردهای فراوانی دارد. با توجه به داشتن اثرات ضددردی و ضدالتهابی گونه های دیگر Salvia مطالعه پیش رو به منظور بررسی اثرات ضد دردی روغن دانه گیاه مریم گلی جنوبی انجام گرفت. روش بررسی: روغن دانه های گیاه با استفاده از روش سوکسله استخراج شد. به منظور بررسی اثر ضددردی، حیوانات در پنج گروه ک...
[ 18 ] - Safety Assessment of Arctium lappa L. Fruit Extract in Female Wistar Rats: Acute and Repeated Oral Toxicity Studies
Background and objectives: Arctium lappa belonging to the Compositae (Asteraceae) family has been used as a medicinal and nutritional supplement in the world. The fruits, leaves and roots of the plant are well-known for their pharmaceutical effects. Toxicity of the fruit’s extract in female rats was investigated in the present study. Methods: To assess...
[ 19 ] - Biochemical and Histopathological Evidence for Beneficial Effects of Pelargonium graveolens Essential Oil on the Rat Model of Inflammatory Bowel Disease
Background and objectives: Pelargonium graveolens L'Hér. is an essential oil bearing plant used in traditional medicine of Iran for the treatment of inflammatory disease and pain, anxiety, sadness and also for the relief of gastrointestinal symptoms. Its pharmaceutical product is presently used in Iran for the treatment of depression disorders. Since colitis is a brain...
[ 20 ] - Safety Assessment of Mentha mozaffarianii Essential Oil: Acute and Repeated Toxicity Studies
Background: Mentha mozaffarianii, an endemic species from the Labiatae family, is used in Iranian traditional medicine. This study evaluated the acute and repeated oral toxicity of the Mentha mozaffarianii essential oil (MMEO) in rats and mice. Methods: To assess the toxicity profile of the MMEO, we administered the essential oil to 48 rats and mice of both sexes by gavage in acute and repeated...
[ 21 ] - N-octyl-modified magnetite NPs for optimization of solid phase extraction for trace analysis of phenytoin in real samples
objective: Phenytoin is an anti-seizure medication used to treat epilepsy, as well as to control arrhythmias (irregular heartbeat) and to treat migraine headaches and nerve pain. It is recommended to determine the amount of this drug in the blood to control the seizure and prevent its toxicity. In the present study, a sensitive and simple procedure based on the dispersive solid phase extraction...
[ 22 ] - The Effect of Voluntary Exercise and Prenatal Exposure to Sodium Valproate on Learning, Memory, and Anxiety of Rats’ Offspring
Background: Antiepileptic drugs, such as sodium valproate (SV), are teratogenic as their usage by the pregnant mother has been associated with an increased risk of major congenital abnormalities in the fetus. In this study, the effects of voluntary exercise and prenatal exposure to SV on learning, memory, and anxiety in rats’ offspring are investigated.Methods: In the present study, 70 fe...
[ 23 ] - Method validation and determination of caffeine in drinks in the Iranian market by the HPLC
Background: Caffeinated energy drinks are common drinks among athletes and general population that have benefits such as providing quick energy, reducing fatigue and creating alertness, but can lead to serious complications in patients, especially those who have cancer and mental, cardiovascular, or renal diseases. The aim of this study was to validate the quantitative analysis and determine ca...
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