هادی ولیزاده

[ 1 ] - تولید نانوژل کیتوزان و گالیک اسید و اثر آن در پایداری اکسیداسیونی سس مایونز حاوی روغن آفتابگردان

در این پژوهش، گالیک اسید با کیتوزان به وسیلهی ماده اتصالی کربودی ایمید با روش تجمع خود به خود با هدف افزایش اثرآنتیاکسیدانی گالیکاسید، رهایش تدریجی و افزایش مدت اثرگذاری بصورت نانوژل تهیه شد. به این صورت که محلول 5/0 درصد کیتوزان با محلول 1اتیل 3دی متیل آمینو پروپیل کربودی ایمید و پودر گالیک اسید مخلوط می‌شود 24 ساعت هم زده میشود سپس تحت عمل سانتریفیوژ قرار گرفته سپس تحت خلاء خشک شده و نها...

[ 2 ] - Preparation and evaluation of PCL-PEG-PCL micelles as potential nanocarriers for ocular delivery of dexamethasone

Objective(s): Micelles have been studied as nanoparticulate drug delivery systems for improving the topical ocular delivery of hydrophobic drugs. The objective of this study was to develop and characterize dexamethasone-loaded polycaprolactone-polyethylene glycol-polycaprolactone (PCL-PEG-PCL) micelles to improve patient compliance and enhance the ocular bioavailability of poorly water-soluble ...

[ 3 ] - Inhibitory effect of clemastine on P-glycoprotein expression and function: an in vitro and in situ study

Objective(s):Transporters have an important role in pharmacokinetics of drugs. Inhibition or induction of drug transporters activity can affect drug absorption, safety, and efficacy. P-glycoprotein (P-gp) is the most important membrane transporter that is responsible for active efflux of drugs. It is important to understand which drugs are substrates, inhibitors, or inducers of P-gp to minimize...

[ 4 ] - Preparation and Evaluation of Poly (s-caprolactone) Nanoparticles-in- Microparticles by W/O/W Emulsion Method

Objective(s) Theophylline, a xanthenes derivative, is still widely used as an effective bronchodilator in the management of asthmatic patients. It is used both as a prophylactic drug and to prevent acute exacerbations of asthma. The aim of study was to formulate and evaluate effect of the microencapsulation of theophylline loaded nanoparticles on the reduction of burst release. Materials and Me...

[ 5 ] - Statistical Optimization of Oral Vancomycin-Eudragit RS Nanoparticles Using Response Surface Methodology

A Box-Behnken design with three replicates was used for preparation and evaluation of Eudragit vancomycin (VCM) nanoparticles prepared by double emulsion. The purpose of this work was to optimize VCM nanoparticles to improve the physicochemical properties. Nanoparticles were formed by using W1/O/W2 double-emulsion solvent evaporation method using Eudragit RS as a retardant material. Full factor...

[ 6 ] - Statistical Optimization of Oral Vancomycin-Eudragit RS Nanoparticles Using Response Surface Methodology

A Box-Behnken design with three replicates was used for preparation and evaluation of Eudragit vancomycin (VCM) nanoparticles prepared by double emulsion. The purpose of this work was to optimize VCM nanoparticles to improve the physicochemical properties. Nanoparticles were formed by using W1/O/W2 double-emulsion solvent evaporation method using Eudragit RS as a retardant material. Full factor...