محمد شکرزاده
دانشیار گروه سم شناسی و فارماکولوژی.گروه سم‌شناسی و فارماکولوژی، دانشکده داروسازی، مرکزتحقیقات علوم دارویی، دانشگاه علوم پزشکی مازندران، ساری، ایران.
[ 1 ] - بررسی پراکندگی پلی مورفیسم ژن SLC30A8 (rs13266634)در بیماران دیابتی نوع 2 در غرب استان مازندران- ایران
زمینه و هدف: دیابت نوع 2یک گروه ناهمگن پیچیده ای از شرایط متابولیکی است که با افزایش سطح قند خون به علت اختلال در عملکرد انسولین و یا ترشح انسولین توصیف می شود. ژن SLC30A8به عنوان یکی از ژنهای عمده مستعدکننده ابتلا به دیابت نوع 2 درنظرگرفته شده است. روش بررسی:دراین مطالعه ی مورد - شاهدی 135 بیمار و 76 فرد سالم...
[ 2 ] - Synergism effects of pioglitazone and Urtica dioica extract in streptozotocin-induced nephropathy via attenuation of oxidative stress
Objective(s): Hyperglycemia promotes oxidative stress that plays a crucial role in the pathogenesis of Diabetic nephropathy (DN). In this study, we investigated the synergism effects of hydroalcoholic extract of Urtica dioica and pioglitazone (PIO) on the prevention of DN in streptozotocin induced-diabetic mice. Materials and Methods: Forty-two mice were divided into six groups as follows: non-...
[ 3 ] - Effects of Cooking Methods on the Concentrations of Lead, Chromium, and Cadmium in Whitefish (Rutilus frissi kutum) from the Caspian Sea, Iran
Today seafood plays a significant role in feeding people worldwide. Identification nutritional value of these products over other protein intake is increasing day by day. In parallel wif the increase in fish consumption, assessment of hygiene and health of these products is important. In this study, Heavy metals (Pb, Cr, and Cd) were investigated in white fish (Rutilus frissi kutum) from th...
[ 4 ] - Embryo-Protective Effects Of Cerium Oxide Nanoparticles Against Gestational Diabetes in Mice
Context: Gestational diabetes is defined as carbohydrate intolerance with onset or first recognition during pregnancy. Diabetes during pregnancy increases the incidences of congenital anomalies, in a mother and her embryo. Oxidative stress has been implicated to be responsible in diabetic embryopathy. Objective: In this study, we used nanoceria as an antioxidant for amelioration of diabetic embry...
[ 5 ] - Preparation of Diaminedicarboxyplatinum (II) Functionalized Single-Wall Carbon Nanotube via Bingel Reaction As a Novel Cytotoxic Agent
Carbon nanotubes have unique properties like high stability, high surface to mass ratio and so on which make them suitable for medicinal purpose applications. Treatment of cancer by organoplatinum agents like Cisplatin has become unresponsive in most cases due to low distribution of drug in biological fluids, inability of drug to cross cellular membranes and low stability in biological environm...
[ 6 ] - Association of rs12108497 (Caspase 3 Gene) Polymorphism in Gastric Cancer Patients in Sari
Gastric cancer is the fourth most common cause of malignancy death in the world, which also has a high prevalence in Iran. Caspase 3 gene is considered one of the major genes related to gastric cancer. The present study aimed to investigate the relationship between rs12108497 polymorphism of Caspase 3 gene. Due to the fundamental role of caspases, we have considered an SNP of Caspase 3 (common ...
[ 7 ] - Increased Expression of CYP2E1 Gene in Gastric Cancer May be a Molecular Marker for Mazandaran Province Population
Cytochrome P450 2E1 (CYP2E1) enzyme metabolically activates a large number of low molecular mass xenobiotics probably involved in gastric cancer incidence through activation of procarcinogens. North of Iran is amongst high incidence rate areas of gastric carcinoma where environmental carcinogenic compounds, including agricultural pesticides, are massively used. In this report, we quantitatively...
[ 8 ] - Embryo-Protective Effects Of Cerium Oxide Nanoparticles Against Gestational Diabetes in Mice
Context: Gestational diabetes is defined as carbohydrate intolerance with onset or first recognition during pregnancy. Diabetes during pregnancy increases the incidences of congenital anomalies, in a mother and her embryo. Oxidative stress has been implicated to be responsible in diabetic embryopathy. Objective: In this study, we used nanoceria as an antioxidant for amelioration of diabetic embry...
[ 9 ] - Preparation of Diaminedicarboxyplatinum (II) Functionalized Single-Wall Carbon Nanotube via Bingel Reaction As a Novel Cytotoxic Agent
Carbon nanotubes have unique properties like high stability, high surface to mass ratio and so on which make them suitable for medicinal purpose applications. Treatment of cancer by organoplatinum agents like Cisplatin has become unresponsive in most cases due to low distribution of drug in biological fluids, inability of drug to cross cellular membranes and low stability in biological environm...
[ 10 ] - علل مسمومیت‌های حاد منجر به بستری نوجوانان در گرگان
Introduction: Acute poisonings in adolescents – a common worldwide problem- is a preventable cause morbidity and mortality. The aim of this study was to determine the causes of acute poisoning in hospitalized adolescents in Gorgan. Methods: This cross-sectional study was conducted on all adolescents (aged 12-19) patients admitted for acute poisoning who are hospitalized in 5 Azar Hospita...
[ 11 ] - بررسی اثرات سلولی نارنجین برپیشگیری از سمیت ژنتیکی ناشی از میفه پریستون بر روی لنفوسیت های خون محیطی انسان
Background and purpose: Mifepristone is an oral synthetic steroid with antiglucocorticoid and antiprogesterone activities. Therefore, it could be dangerous during pregnancy since it causes cytogenetic damage and, consequently, abortion. Flavonoid compounds such as naringin have antioxidant properties and eliminate various free radicals. Naringin is abundantly found in Iran, so, we investigated ...
[ 12 ] - مهار ژن هومانین جهت بررسی اثرات آن در اثر بخشی داروی Etoposide در رده سلولی سرطان معده
Background and purpose: Humanin is a 24-aa peptide that is considered as one of the probable players of autophagy. Its inevitable role in the inhibition of apoptosis in cells is revealed, but its probable importance in autophagy is under evaluation. This study evaluated the role of humanin protein in induction of autophagy and efficacy of chemotherapy drug etoposide. Materials and methods: HN3...
[ 13 ] - بررسی همراهی پلی مورفیسم G>A(rs4647603)ژن کاسپاز 3 با آدنوکارسینوم معده در جمعیت شمال ایران
Background and purpose: Gastric cancer is the second most common cause of cancer worldwide. Having a genetic predisposition plays an important role in cancer development. Defects in the apoptosis way may cause accumulation of immortal cells that ultimately lead to numerous disorders, including cancer. In both domestic and foreign apoptosis ways, casepase 3 plays a key role as executive casepase...
[ 14 ] - اپیدمیولوژی فوت ناشی ازمسمومیت باعوامل دارویی در شهرهای مرکزی استان مازندران طی سال های 1390-1395
Background and purpose: Drug-poisoning is amongst major health problems throughout the world. Evidence shows high prevalence of drug-poisoning in Iran. This study investigated the epidemiology of drug-poisoning death in central cities of Mazandaran province (Sari, Qaemshahr, Behshahr, Juybar, and Chhardangeh). Materials and methods: We conducted a cross-sectional analysis of all fatality recor...
[ 15 ] - بررسی میزان باقی مانده سموم دیازینون و مالاتیون در خیار تولیدی استان مازندران در سال 1394
Background and purpose: Pesticides can accumulate in the body due to chronic toxicity. This accumulation is caused by direct exposure to the chemicals or indirect exposure, i.e. foods, breathing, and skin. This study was performed to assess the levels of diazinon and malathion residues in cucumber produced in Mazandaran province, Iran. Materials and methods: In this experimental study,...
[ 16 ] - اپیدمیولوژی فوت ناشی از مسمومیت با گاز مونوکسید کربن در استان گلستان در سال های 1394-1389
Background and purpose: Carbon monoxide (CO) is one of the most common causes of death due to poisoning in Iran. This study is an epidemiological survey of death due to CO poisoning in Golestan province, Iran. Materials and methods: This cross-sectional study was carried out on all profiles of referential bodies to Golestan Department of Forensic Medicine who died due to CO poisoning bet...
[ 17 ] - ارزیابی سمیت تحت حاد و تحت مزمن عصاره آبی چای کوهی بر موش صحرایی
Background and purpose: Therapeutic effects of Stachys lavandulifolia include anxiolytic effects also, it has beneficial effects in rheumatic diseases, genital tumors and cancerous ulcers but it showed adverse effects on liver and kidney. We investigated the subacute and subchronic toxic effect of Stachys lavandulifolia water extract in rat. Materials and methods: The animals were randomly div...
[ 18 ] - روی و مس در کولیت اولسراتیو
Background and purpose: Ulcerative colitis (UC), a subtype of inflammatory bowel diseases (IBD), is an immune-mediated chronic intestinal condition. Changes in the copper (Cu) and zinc (Zn) concentrations have been reported previously in IBD. Due to controversial results, the aim of this study was to evaluate and compare serum and urine levels of Zn and Cu in patients with UC and control group....
[ 19 ] - بررسی غلظت کادمیوم، کروم و سرب در برنج چمپا شهرستان مبارکه در سال 1388
Introduction: Since, rice is the main source of food for the majority of people in the world, including Iran, determine of concentration and distribution of heavy metals in rice plants is important. The aim of this study was to determine cadmium, chromium and zinc concentrations in rice produced of the Mobarakeh County. Material and Method: Sampling was conducted based on stratified random met...
[ 20 ] - ارزیابی میزان باقی مانده سموم اورگانو فسفره در برنج تولیدی شهرستان آمل در شمال ایران
Background and purpose: Organophosphorous insecticides are chemical substances that are widely used globally against plant pests and diseases, led to an increase in farm productivity. On the other hand, their excessive use/misuse especially in the developing countries, their volatility, long-distance transports eventually results in widespread environmental contamination that creating serious a...
[ 21 ] - بررسی تاثیر سمپاشی همراه با فرآیندهای نگهداری میوه خیار بر باقیمانده سم دیازینون
Background and purpose: Âccumulation of toxic agents in food, water, soil and air is an important concern of human health and environmental safety. Ïn this study, residual content of Diazinon at different days after spraying pesticide was measured and reducing factors were analyzed. Materials and methods: Ïn this study cultivated cucumbers were exposed to specific concentrations of Diazino...
[ 22 ] - بررسی فلزات سنگین (سرب، کادمیوم، کروم و روی) در آب و رسوب سواحل استان گلستان
چکیده حضور فلزات سنگین بیش از استاندارد تعریف شده در زیستگاهای آبی می تواند باعث بروز مشکلات و عوارض زیست محیطی قابل توجهی برای موجودات آبزی شود. در این تحقیق غلظت فلزات سنگین (سرب، کادمیوم، کروم و روی) در 4 منطقه سواحل غربی و شرقی استان گلستان، تالاب گمیشان و خلیج گرگان در آب و رسوباب در 11 ایستگاه مورد بررسی و اندازه گیری قرار گرفت. اندازه گیری فلزات در آب و رسوب از روش اسپکتروفتومتری جذب اتم...
[ 23 ] - A review of acrylamide toxicity and its mechanism
Acrylamide (AA) is an important industrial chemical agent that is mainly used in the production of polymers and copolymers. Recently it has been attention because of its production in the diet at high-temperature (>120 ºC) processes such as cooking, frying, toasting, roasting or baking of high carbohydrate foods. According to high exposure to acrylamide, recognition of its toxic effect is ...
[ 24 ] - Study of cyp2E1 gene RsaI/PstI polymorphisms in patients with gastric cancer in north of Iran
Background: North of Iran is amongst high incidence rate areas of gastric carcinoma where environmental carcinogenic compounds especially agricultural pesticides are massively used. Cytochrome P450 2E1 (CYP2E1) enzyme metabolically activates a large number of low molecular mass xenobiotics. The polymorphic nature of cyp2E1 gene control elements is associated with interindividual differences...
[ 25 ] - Organ toxicity attenuation by nanomicelles containing curcuminoids: Comparing the protective effects on tissues oxidative damage induced by diazinon
Objective(s): Diazinon (DZ) is an organophosphate pesticide that induces oxidative damage in different organs. The aim of this study was to compare the effectiveness of nanomicelles containing curcuminoids (NCUR) and natural curcumin (CUR) in attenuating the oxidative damage induced by DZ in male rats. Materials and Methods: After a single intraperitoneal (IP) injection of DZ (100 mg/kg), the r...
[ 26 ] - بررسی پراکندگی پلی مورفیسم ژن TCF7L2 (rs7903146) در بیماران دیابتی نوع 2 در غرب مازندران ایران
مقدمه: دیابت نوع 2 یک گروه ناهمگن پیچیده ای از شرایط متابولیکی است که با افزایش سطح قند خون به علت اختلال در عملکرد انسولین و یا ترشح انسولین توصیف می شود. ژن TCF7L2 به عنوان یکی از ژنهای عمده مستعد ابتلا به دیابت در نظر گرفته شده است. پلی مورفیسم تک نوکلئوتیدی rs7903146 واقع در اینترون شماره 3 این ژن می باشد که به طور قابل توجهی با دیابت نوع 2 موثر است. مواد و روش‌ها: در این مطالعه ی مورد – ش...
[ 27 ] - Anticancer Effects of Deoxypodophyllotoxin and Juniperus communis L. on Prostate Cancer Cell Lines
Background and purpose: In this study, the effects of a mixture of deoxypodophyllotoxin/DPT and Juniperus communis L. on apoptosis and cellular inhibition were evaluated. Also, their cytotoxicity effects on prostate cancer cells (PC3 and DU145) and normal cells (HGFs), their anti-inflammatory effects, oxidation properties, and their effects on the expression of androgen receptors (AR) and clust...
[ 28 ] - Contamination Assessment and Zoning of Heavy Metals in Water and Sediment of Alagol Wetland, Iran 2017
Background and purpose: Heavy metal pollution is among the most serious environmental issues that is caused directly or indirectly through human activities or natural sources. Alagol wetland is one of the most important ecosystems in Iran which is affected by numerous agricultural and industrial development programs. Materials and methods: A descriptive cross-sectional study was performed in s...
[ 29 ] - Effects of Flaxseed (Linum Usitatissimum L.) against Genotoxicity Induced by Cyclophosphamide on Human Blood Lymphocyte
Introduction: Medicinal plants, such as flaxseeds play an important role in the health of individuals and communities. Regarding the phytochemical properties of flaxseed, this study aimed to investigate the hydroalcoholic effects of this plant on the genetic toxicity of cyclophosphamide in peripheral blood lymphocytes. Materials & Methods: The flaxseed extract was initially prepared by macer...
[ 30 ] - Self-Medication Practice and Associated Factors among Adults in Gorgan, North of Iran
Background and Purpose: Self-medication is an important concern in every part of the world. The aim of this study was to estimate the prevalence and to investigate the associate factors of self-medication among adults in Gorgan, north of Iran. Materials and Methods: This descriptive cross-sectional study was carried out among adults aged 12 years and above who were residents in Gorgan city. T...
[ 31 ] - Association of the -160 C>A Polymorphism in the CDH1 Promoter with Gastric Cancer: A Case-control Study
E-cadherin is a tumor suppressor protein that plays a crucial role in cell-cell adherens junction and tissue architecture and it is hypothesized to participate in carcinogenesis. It has been shown that a polymorphism in the upstream of the transcription start site of the CDH1 gene affects E-cadherin transcriptional regulation and seems to be associated with a variety of cancers. For the first t...
[ 32 ] - Evaluation of the Anti-apoptotic and Anti-cytotoxic Effect of Epicatechin Gallate and Edaravone on SH-SY5Y Neuroblastoma Cells
Introduction: Parkinson disease (PD) is the second most common neurodegenerative disease affecting older individuals with signs of motor disability and cognitive impairment. Epicatechin (EC) and edaravone have neuroprotective effects most probably due to their antioxidant activity; however, a limited number of studies have considered their role in PD. This research aimed at investigating the ne...
[ 33 ] - The Protective Effects of Origanum vulgare L. Extract on Genetic Damage of Cyclophosphamide in Mice Blood Lymphocytes Using Micronucleus Test
Despite its various clinical applications, cyclophosphamide (CP), an alkylating chemotherapeutic agent, has demonstrated numerous side effects, including genetic toxicity. This study investigated the protective action of Origanum vulgare L., a powerful antioxidant plant, on the genotoxicity of CP in the mice blood lymphocytes. The mice were pretreated orally with different doses of (50, 100, 20...
[ 34 ] - A review of the requirements and hazards of toxic metals from orthodontic wires
Background: Orthodontics is a part of dentistry that includes preventive methods and correction of dental irregularities that need to be repositioned by functional and mechanical tools to provide an ideal occlusion and a beautiful face for patients. There are currently four metal arch wires used in orthodontic treatment: stainless steel alloy, cobalt-chromium alloy, nickel-titanium alloy, and b...
[ 35 ] - Epidemiology of Tramadol Poisoning in Qaemshahr, Iran
Background and purpose: Tramadol poisoning is a serious medical emergency and one of the most common causes of drug poisoning. The present study aims to determine the epidemiological features of patients who were served by Qaemshahr pre-hospital emergency care due to tramadol toxicity in 2016. Materials and methods: In this descriptive cross-sectional study, medical records of patients with...
[ 36 ] - Protective Effects of Simvastatin on Cytotoxicity and Oxidative Stress in Human Gingival Fibroblasts Cells Exposed to Venlafaxine
Background and purpose: Venlafaxine is an antidepressant that belongs to the family of selective serotonin and norepinephrine reuptake inhibitor (SNRIs) drugs. Recent studies have indicated that prolonged use of antidepressants leads to a state where increased formation of reactive oxygen species (ROS) overwhelms body antioxidant protection and subsequently induces DNA damage, lipid peroxidatio...
[ 37 ] - Effect of Clarithromycin on Enhancement of Doxorubicin-induced Cytotoxicity and Apoptosis in A549 Tumor-Cell Line
Background and purpose: Nowadays, multi-drug regimens or combination therapy are new approaches in cancer treatment that combine two or several therapeutic agents. Combination therapy aims at improving the therapeutic efficacy of anticancer drugs while reducing toxicity and preventing drug resistance. The aim of this study was to determine the synergistic effect of combined clarithromycin and d...
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