مریم صاحباری
دانشیار روماتولوژی مرکز تحقیقات بیماریهای روماتیسمی، دانشکده پزشکی، دانشگاه علوم پزشکی مشهد،مشهد، ایران
[ 1 ] - آدیپوکینازها : رزیستین و بیماریهای روماتیسمی
در سالهای اخیر ،اپیدمی جهانی افزایش وزن منجر به افزایش توجه به شناخت بیولوژی بافت چربی سفید شده است. آدیپوسیت ها و ماکروفاژهای موجود در نسج چربی تولیدکننده چندین پروتئین واسطه ای تحت عنوان آدیپوکین ها است. آدیپوکین ها شامل انواع مختلفی از پپتیدها با خواص پیش التهابی از جمله لپتین ، رزیستین، لیپوکالین 2، اینترلوکین 18 واثرات ضد التهابی مثل آدیپونکتین می باشند. رزیستین یکی از این پپتیدهای جدی...
[ 2 ] - بررسی خصوصیات بالینی و اپیدمیولوژیک 100بیمار مبتلا به سارکوئیدوز و آرتریت سارکوئیدی
مقدمه سارکوئیدوز یک بیماری گرانولوماتوز چندعضوی با علت ناشناخته است که ارگانهای مختلف را با شیوع متفاوت درگیر میکند. سندرم لوفگرن از اشکال سارکوئیدوز حاد به شکل آرتریت،اریتم ندوزوم و آدنوپاتی ناف ریه است. روش کار در این مطالعه توصیفی آینده نگر که در سال های 1389-1392 در درمانگاه های روماتولوژی مشهد انجام شد، 100 بیمار مبتلا به سارکوئیدوز حاد که تشخیص آنها توسط روماتولوژیست اثبات شده بود توسط ...
[ 3 ] - بررسی ارتباط بین سطح سرم HSP27 در بیماران با و بدون یووئیت مبتلا به بیماری بهجت
مقدمه بیماری بهجت یک بیماری خودایمن و مزمن است که می تواند چندین سیستم بدن را درگیر کند. اثر پروتئین های شوک گرمایی و آنتی بادیهای ضد آن از عواملی هستند که در اتیولوژی و بیماری زایی بهجت شرح داده شده اند. هدف اصلی در این مطالعه تعیین سطح سرمی HSP27 در بیماران بهجت و ارتباط آن با یووئیت در این بیماران بود. روش کار مطالعه حاضر یک مطالعه توصیفی- مقطعی متشکل از 94 نفر است که در بیمارستان خ...
[ 4 ] - Brain Single Photon Emission Computed Tomography Scan (SPECT) and Functional MRI in Systemic Lupus Erythematosus Patients with Cognitive Dysfunction: A Systematic Review
Objective(s): Systemic lupus erythematosus (SLE) is an autoimmune disease with a wide range of clinical manifestations. Cognitive dysfunction is one of the manifestations that could present prior to the emergence of any other neuropsychiatric involvements in SLE. Cognitive dysfunction is a subtle condition occurring with ahigh frequency. However, there is no data on the correlation of cognitive...
[ 5 ] - Choosing a Medical Specialty: Factors Considered by Iranian General Practitioners
Background: For medical students, the selection of a specialty is one of the most critical decisions to be made. On a personal level, it determines lifetime career achievements and, for the community, it directly affects the outcome of public health programs. The aim of this study was to investigate which factors were more important among Iranian residents when considering a specialty. Methods:...
[ 6 ] - Influence of 1 Alpha, 25-Dihydroxyvitamin D3 on T Helper 17 Cells and Related Cytokines in Systemic Lupus Erythematosus
Background: Systemic lupus erythematosus (SLE) is a multisystem autoimmune disease. Emerging data suggests that T helper 17 (Th17) cells play a pathogenic role in SLE and the increased number of these cells correlates with disease activity. In recent years, 1α, 25-dihydroxyvitamin D3 (1,25VitD3) has been considered as an immunomodulatory factor. Objective: To investigate the effect of 1,25VitD3...
[ 7 ] - Serum alpha–actinin antibody status in systemic lupus erythematosus and its potential in the diagnosis of lupus nephritis
Background: In lupus nephritis (LN), deposition of pathogenic autoantibodies in the glomeruli is mediated via cross-reactivity with alpha-actinin. Association of serum alpha-actinin antibody (AαA) with LN has been shown in a few studies but the results are controversial. Methods: Eighty patients into entered the study. The diagnosis of SLE was confirmed according to the American College of Rheu...
[ 8 ] - Metabolic syndrome in lupus patients in northeast of Iran, and their lifestyle habits
Background: Systemic lupus erythematous is an autoimmune disease associated with atherosclerotic manifestations or metabolic disturbance due to inflammation. The aim of this study was to determine frequency of metabolic syndrome (MetS) in SLE compared to healthy controls. Methods: In this cross-sectional study, 150 SLE patients and 220 healthy volunteers were enrolled. MetS was diagnosed acc...
[ 9 ] - Skin inflammatory reactions to capsaicin in rheumatoid arthritis patients compared to healthy controls
Objective: Previous studies have examined the role of sensory nerves and neural mediators in symmetrical joint inflammation and autoimmunity in rheumatoid arthritis (RA). In this study, we sought to examine the association between capsaicin skin test and disease activity in RA patients. Materials and Methods: Eighty RA patients (case group) and 20 healthy volunteers were enrolled in this experi...
[ 10 ] - Preoperative Evaluation and Management of Patients Receiving Biologic Therapies
The preoperative care of patients undergoing orthopedic surgery and treated with biologic agents is of great significance.Perioperative use of biologic agents could lead to such complications as infection and delayed postoperative woundhealing. This narrative review aimed to evaluate the current information on the use of biologic agents in patientsundergoing orthopedic surgery...
[ 11 ] - Evaluation of clinical symptoms and sonographic characteristics of femoral trochlear cartilage in primary knee osteoarthritis
Objective: This study was designed to evaluate the clinical symptoms and sonographic characteristics of femoral trochlear cartilage in patients with knee joint osteoarthritis (OA). Methods: This cross-sectional study was conducted on 94 patients with painful primary knee OA according to the American College of Rheumatology criteria with a visual analog scale pain score of 30 mm or more. Clinica...
[ 12 ] - Skin reaction to capsaicin in patients with Systemic Lupus Erythematosus compared to that in healthy controls
Background: The interaction between nervous and immune systems has been under investigation. Transient receptor potential vanilloid type 1(TRPV1) is a ligand gated calcium channel expressed by sensory neurons which mediates neurogenic inflammatory response. Substance p which can be released following exposure to capsaicin is a TRPV1 inducer, shown to have altered concentration and function in m...
[ 13 ] - The effect of Pilates exercises on the pain and the flexor and extensor knee muscles momnetum in women with rheumatoid arthritis
Aims and background: Rheumatoid arthritis is an inflammatory, autoimmune, chronic, and progressive connective tissue disease with an unknown cause that is associated with symptoms such as pain, swelling, tenderness, stiffness, and dryness in the joints and decreased energy, leading to muscle inactivity and atrophy. The aim of this study was to investigate the effect of Pilates exercises on ...
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