بهرام رسولیان
دانشیار، مرکز تحقیقات داروهای گیاهی رازی، دانشگاه علوم پزشکی لرستان، خرم آباد ، ایران.
[ 1 ] - اثر تعاملی تمرین هوازی و مصرف عصاره آبی کلاله زعفران بر میزان مالون دی آلدئید و سیستم آنتی اکسیدانی قلب و ناحیه پیش‌حرکتی کورتکس مغز موشهای صحرایی نر جوان پس از یک جلسه فعالیت حاد وامانده‌ساز
هدف از تحقیق حاضر بررسی اثر تعاملی تمرین هوازی و مصرف عصاره آبی کلاله زعفران بر میزان مالون دی آلدئید و سیستم آنتی اکسیدانی قلب و ناحیه پیش‌حرکتی کورتکس مغز موشهای صحرایی نر جوان پس از یک جلسه فعالیت حاد وامانده‌ساز بود. 64 سر موش3 ماهه (وزن26±212) در چهار زیر گروه (هر زیرگروه 16 سر) [ 1-=CW مصرف آب مقطر ؛2- CSW= مصرف عصاره آبی زعفران ؛3-= ETW مصرف آب مقطر +تمرین ؛4-= ETSW مصرف عصاره آبی زعفرا...
[ 2 ] - Effect of normobaric hyperoxia on gentamicin-induced nephrotoxicity in rats
Objective(s):Gentamicin sulphate (GS) nephrotoxicity seems to be related to the generation of reactive oxygen species. There is evidence that oxygen preconditioning increases the activity of antioxidant enzymes. Materials and Methods: Forty eight female rats were divided into 6 groups (n=8) as follows: group 1 was the control, group 2 received daily GS, groups 3,4 and 5 received oxygen 2 hr/day...
[ 3 ] - Prolonged Oral Administration of Oleuropein Might Protect Heart against Aconitine-induced Arrhythmia
In this study, it was surveyed to know whether an oral single dose of oleuropein could mimic the cardiac preconditioning in rats’ hearts or whether its prolonged oral administration could protect the heart against the aconitine-induced arrhythmia in rats. Eighty male Wistar rats were divided into two series (n = 8 in each group). In the first series, all groups (except the control (Con) group) ...
[ 4 ] - Prolonged Oral Administration of Oleuropein Might Protect Heart against Aconitine-induced Arrhythmia
In this study, it was surveyed to know whether an oral single dose of oleuropein could mimic the cardiac preconditioning in rats’ hearts or whether its prolonged oral administration could protect the heart against the aconitine-induced arrhythmia in rats. Eighty male Wistar rats were divided into two series (n = 8 in each group). In the first series, all groups (except the control (Con) group) ...
[ 5 ] - تأثیر پیش‌درمانی با مقادیر مختلف ال-آرژینین بر نفروپاتی ناشی از سیسپلاتین در موشهای صحرایی نر
Introduction: Cisplatin is a widely used anti-cancer drug, which its application is limited by nephrotoxicity. In this study, the effect of pretreatment with different l-arginine doses on Cisplatin-induced renal functional injury was investigated. Methods: 63 male rats were divided into 7 groups: In groups 3, 4, 5 and 6, 60 min before the Cisplatin injection (5mg/kg); L-Arginine with doses o...
[ 6 ] - بررسی تأثیر پیش‌درمانی با اکسیژن بر مهار نفروتوکسیسیتی حاد القا شده به وسیله جنتامایسین در رت
Introduction: The toxicity of gentamycin in the kidney seems to be related to the generation of reactive oxygen species (ROS). There is evidence that pretreatment with oxygen increases the rate and activity of antioxidant enzymes. Methods: In this experimental study, forty eight female rats (Sprague Dawlley) were divided into 6 groups randomly (8 in each) as follows: group 1 was the control an...
[ 7 ] - اثر تجویز اسانس گیاه مرزه خوزستانی بر شدت آسیب کلیوی ناشی از تجویز سیسپلاتین در موشهای صحرایی
Cisplatin is a major chemotherapeutic drug in the treatment of some cancers and nephropathy is its main side effect. Reactive oxygen species have an important role in the nephrotoxicity of this drug. The goal of the present study was to investigate the effect of Satureja Khuzestanica essential oil, which contains antioxidant agents, on Cisplatin induced nephropathy. Materials and Methods: This...
[ 8 ] - کاهش نسبی آسیب کلیوی ناشی از سیسپلاتین در موشهای صحرایی از طریق پیش درمانی با عصاره برگ زیتون
Cisplatin is a major anti-neoplastic agent which nephrotoxicity is its main side effect and limits its usage in cancer chemotherapy. Reactive oxygen species (ROS) are highly responsible for cisplatin induced nephropathy, so we determined the effects of oral administration of ethanolic olive leaf extract (OLE) as a plant antioxidant on nephrotoxicity of this drug. Material and methods: 21 adult...
[ 9 ] - Evaluating the effect of short ischemic periods on subsequent rat renal ischemic injury
Introduction: Using brief episodes of ischemia and reperfusion (IR) prior to a more sustained IR insult – ischemic preconditioning (IPC) – can reduce IR injury of the heart, brain and many other tissues. The purpose of present study was to investigate the effect of 2min ischemic periods on subsequent rat renal IR injury. Methods: Male rat's renal IR injury was investigated in a right nephrectom...
[ 10 ] - Cardioprotective effect of ethanolic leaf extract of Melissa officinalis L against regional ischemia-induced arrhythmia and heart injury after five days of reperfusion in rats
Abstract Melissa officinalis has antioxidant and anti-inflammatory activities and is used in various diseases. Aim of the study: We investigated the role of M. officinalis extract (MOE) against ischemia-induced arrhythmias and heart injury after five days of reperfusion in an in-vivo rat model of regional heart ischemia. The leaf extract of M. officinalis was standardized thr...
[ 11 ] - Cardioprotective effect of ethanolic leaf extract of Melissa officinalis L against regional ischemia-induced arrhythmia and heart injury after five days of reperfusion in rats
Abstract Melissa officinalis has antioxidant and anti-inflammatory activities and is used in various diseases. Aim of the study: We investigated the role of M. officinalis extract (MOE) against ischemia-induced arrhythmias and heart injury after five days of reperfusion in an in-vivo rat model of regional heart ischemia. The leaf extract of M. officinalis was standardized thr...
[ 12 ] - The Effect of 6 Weeks Aerobic Training and Aqueous Extract of Caraway Seed (Carum Carvi) on the Expression of CTRP12 Gene, Body Weight Changes and Subcutaneous Adipose Tissue in Obese Male Rats: An Experimental Study
Background and Objectives: Caraway (Carum carvi) is one of the medicinal plants which is traditionally used for weight loss. The purpose of the present study was to determine the effect of 6 weeks aerobic training and aqueous extract of caraway seed (carum carvi) on expression of CTRP12 gene, body weight changes and subcutaneous adipose tissue in obese male rats. Materials and Methods: In this...
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