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دانشیار مرکز تحقیقات علوم اعصاب دانشگاه علوم پزشکی، دانشگاه شهید بهشتی
[ 1 ] - تأثیر یک جلسه فعالیت تداومی و تناوبی با شدت بالا بر شاخص هایپوکسی و التهاب در بافت چربی موشهای چاق نر ویستار
هدف از انجام این تحقیق بررسی تأثیر یک جلسه فعالیت تداومی و تناوبی با شدت بالا بر سطوح HIF-1α و TNF-α در بافت چربی موشهای چاق نر ویستار بود. آزمودنیها شامل 30 سر موش 16 هفتهای چاق بود که به مدت هشت هفته از رژیم پرچرب استفاده کرده بودند. آزمون واماندهساز پیشبین حداکثر اکسیژن مصرفی برای تعیین شدت فعالیت انجام شد. سپس حیوانات به گروههای کنترل، فعالیت تداومی و HIIE تقسیم شدند. فعالیت HIIE شام...
[ 2 ] - تأثیر یک دوره مکمل‌دهی ال‌آرژنین بر پاسخ گیرندۀ نیکوتینی استیل کولین عضلۀ اسکلتی موشهای صحرایی نر سالمند به فعالیت حاد واماندهساز
هدف از انجام این پژوهش، بررسی تأثیر یک دوره مکمل‌دهی ال‌آرژنین بر پاسخ گیرندۀ نیکوتینی استیل کولین بافت عضلات اندام عقبی موشهای صحرایی سالمند به فعالیت حاد واماندهساز بود. بدین‌منظور، 32 سر موش نر نژاد ویستار (22ماهه،20±380 گرم) آزمودنی‌های این پژوهش را تشکیل دادند و به‌طور تصادفی به چهار گروه مکمل ال‌آرژنین همراه با فعالیت استقامتی واماندهساز بلافاصله، مکمل ال‌آرژنین بلافاصله، ورزش و ...
[ 3 ] - تأثیر هشت هفته تمرین استقامتی همراه با مهار nNOS بر میزان پروتئین گیرنده‌های نیکوتینی استیل کولین عضلة اسکلتی موشهای صحرایی مسن
پیوندگاه عصب ـ عضله(NMJ) طی سالمندی تغییرات عمده‌ای از جمله کاهش فعالیت نیتریک اکساید سنتاز نورونی (nNOS) می‌یابد که در نهایت سبب تضعیف عملکرد جسمانی و بروز سارکوپنیا می‌گردد. هدف از انجام این پژوهش تعیین تأثیر هشت هفته تمرین استقامتی همراه با مهار nNOS بر میزان پروتئین گیرنده‌های نیکوتینی استیل کولین (nAchR) بود. تولید نیتریک اکساید (NO) بوسیله دو دوز mg-1.kg-1.day -1 25 و 100 N G نیترو- L – آ...
[ 4 ] - Protective effect of a polyherbal traditional formula consisting of Rosa damascena Mill., Glycyrrhiza glabra L. and Nardostachys jatamansi DC. , against ethanol-induced gastric ulcer
“VARD” formula consisting of Rosa damascena Mill. (Rosaceae) petal, and rhizomes of Glycyrrhiza glabra L. (Papilionaceae) and Nardostachys jatamansi DC. (Valerianaceae), has been proposed for gastric ulcer in Iranian traditional medicine. We investigated the antiulcer activity of each plant separately and in combination. The biochemical and molecular function of extracts was also evaluated. Eac...
[ 5 ] - Ameliorating of Memory Impairment and Apoptosis in Amyloid β-Injected Rats Via Inhibition of Nitric Oxide Synthase: Possible Participation of Autophagy
It has been proposed that appearance of amyloid beta (Aβ) in hippocampus is one of the characteristic features of Alzheimer’s disease (AD). The role of Nitric oxide (NO) in neurodegenerative disorders is controversy in different contexts. Here, we examined the effect of NO on spatial memory. For this purpose, we compared the effects of three different concentrations of L-NG-Nitroarginine Methyl...
[ 6 ] - Protective effect of a polyherbal traditional formula consisting of Rosa damascena Mill., Glycyrrhiza glabra L. and Nardostachys jatamansi DC. , against ethanol-induced gastric ulcer
“VARD” formula consisting of Rosa damascena Mill. (Rosaceae) petal, and rhizomes of Glycyrrhiza glabra L. (Papilionaceae) and Nardostachys jatamansi DC. (Valerianaceae), has been proposed for gastric ulcer in Iranian traditional medicine. We investigated the antiulcer activity of each plant separately and in combination. The biochemical and molecular function of extracts was also evaluated. Eac...
[ 7 ] - Ameliorating of Memory Impairment and Apoptosis in Amyloid β-Injected Rats Via Inhibition of Nitric Oxide Synthase: Possible Participation of Autophagy
It has been proposed that appearance of amyloid beta (Aβ) in hippocampus is one of the characteristic features of Alzheimer’s disease (AD). The role of Nitric oxide (NO) in neurodegenerative disorders is controversy in different contexts. Here, we examined the effect of NO on spatial memory. For this purpose, we compared the effects of three different concentrations of L-NG-Nitroarginine Methyl...
[ 8 ] - P42: Luteolin Counteracts ER Stress in PC12 Cells through Moderating ER Chaperones and Heat Shock Proteins
لطفاً به چکیده انگلیسی مراجعه شود.
[ 9 ] - Actors of necroptosis scenario in cell\'s scene
Necroptosis, as a novel concept, has been recently introduced in scientific literature. Much of our knowledge about necroptosis comes from ligation of tumor necrosis factor-α to its receptor, TNF receptor 1. Receptor-interacting protein kinase 1, receptor-interacting protein kinase 3 and its substrate, the pseudokinase mixed lineage kinase domain-like protein, have been comprehensively st...
[ 10 ] - A comprehensive approach to investigate the contradictory effects of metformin therapy in cerebral ischemic injury
Ischemic brain injury involves a complex sequence of excitetoxic and oxidative events. Metformin is proposed as one of the potential candidates for returning the body to its basic homeostasis in ischemic situations. Metformin can either protect or damage cells by activating AMP-activated protein kinase (AMPK) and its downstream factors so, it has a dual role in the cerebral ischemia context, bu...
[ 11 ] - A molecular study on the endoplasmic reticulum potassium channels in hepatocytes
Introduction: It has recently been suggested that the KATP channel subunits Kir6.x and BKCa channels exist in the endoplasmic reticulum of cardiomyocytes and neurons. Our previous studies showed the electrophysiological behavior of cation channels in the rough endoplasmic reticulum (RER) of rat hepatocytes. Therefore, we hypothesized that KATP channels and Ca2+-activated potassium channels m...
[ 12 ] - Effect of morphine on apoptotic factors caspase-3, PARP and Bax/Bcl-2 ratio in nucleus accumbens in conditioned place preference model in rat
Introduction: Nucleus accumbens (NAc) plays a critical role in neuronal reward circuits that are responsible for motivated and goal-directed behaviors. Some data suggest that morphine induces apoptosis in neurons, while other evidences show that morphine could have beneficial effects against neuronal cell death. This study was designed to evaluate the effect of morphine on apoptosis in the N...
[ 13 ] - Peroxisomal Malfunction Caused by Mitochondrial Toxin 3-NP: Protective Role of Oxytocin
Peroxisomes are single membrane cell organelles with a diversity of metabolic functions. Here we studied the peroxisomal dysfunction and oxidative stress after 3-nitropropionic acid (3-NP) induced neurotoxicity and the possible protective effects of oxytocin. Adult male and female rats were subjected to Oxt and/or 3-NP treatment. The antioxidant enzymes, Superoxide dismutase (SOD) and Catalase ...
[ 14 ] - Peroxisomal Malfunction Caused by Mitochondrial Toxin 3-NP: Protective Role of Oxytocin
Peroxisomes are single membrane cell organelles with a diversity of metabolic functions. Here we studied the peroxisomal dysfunction and oxidative stress after 3-nitropropionic acid (3-NP) induced neurotoxicity and the possible protective effects of oxytocin. Adult male and female rats were subjected to Oxt and/or 3-NP treatment. The antioxidant enzymes, Superoxide dismutase (SOD) and Catalase ...
[ 15 ] - Mitochondrial Complex I Is an Essential Player in LPS-Induced Preconditioning in Differentiated PC12 Cells
Preconditioning (PC) as a protective strategy against noxious insults can decline cell death and apoptosis. It has been approved that mitochondria play a key role in PC mechanism. The critical role of complex I (CI) in oxidative phosphorylation machinery and intracellular ROS production, particularly in the brain, accentuates its possible role in PC-induced neuroprotection. Here, differentiated...
[ 16 ] - Calcium Channel Blockade Ameliorates Endoplasmic Reticulum Stress in the Hippocampus Induced by Amyloidopathy in the Entorhinal Cortex
Entorhinal cortex (EC) is one of the first Entorhinal cortex (EC) is one of the first cerebral regions affected in Alzheimer’sdisease (AD). The pathology propagates to neighboring cerebral regions through a prion-likemechanism. In AD, intracellular calcium dyshomeostasis is associated with endoplasmicreticulum (ER) stress. This study was designed to examine hippocampal ER stre...
[ 17 ] - Mitochondrial Complex I Is an Essential Player in LPS-Induced Preconditioning in Differentiated PC12 Cells
Preconditioning (PC) as a protective strategy against noxious insults can decline cell death and apoptosis. It has been approved that mitochondria play a key role in PC mechanism. The critical role of complex I (CI) in oxidative phosphorylation machinery and intracellular ROS production, particularly in the brain, accentuates its possible role in PC-induced neuroprotection. Here, differentiated...
[ 18 ] - Calcium Channel Blockade Ameliorates Endoplasmic Reticulum Stress in the Hippocampus Induced by Amyloidopathy in the Entorhinal Cortex
Entorhinal cortex (EC) is one of the first Entorhinal cortex (EC) is one of the first cerebral regions affected in Alzheimer’sdisease (AD). The pathology propagates to neighboring cerebral regions through a prion-likemechanism. In AD, intracellular calcium dyshomeostasis is associated with endoplasmicreticulum (ER) stress. This study was designed to examine hippocampal ER stre...
[ 19 ] - Neuronal injury and death following focal mild brain injury: The role of network excitability and seizure
Objective(s): While traumatic brain injury (TBI) is a predisposing factor for development of post-traumatic epilepsy (PTE), the occurrence of seizures following brain trauma can infuriate adverse consequences of brain injury. However, the effect of seizures in epileptogenesis after mild TBI cannot yet be accurately confirmed. This study was designed to investigate the ...
[ 20 ] - The Effects of Noise and Whole Body Vibration on Urinary Metanephrine and Normetanephrine
Background and Aim: Little attention has been paid to the effects of combined exposure to noise and vibration. Exposure to noise and vibration can effect stress hormones and may lead to high blood pressure and cardiovascular disorders. This study aims to investigate the effects of noise and vibration on urinary Metanephrine and Normetanephrine among men. Methods: In this experimental study, 30 ...
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