سمانه ذوالقدری
پژوهشگاه علوم و فنون هسته‌ای، سازمان انرژی اتمی ایران
[ 1 ] - بررسی امکان استفاده از ترکیب عناصر سرب، تنگستن و باریم به منظور افزایش بازده ی روپوش های محافظ در تضعیف پرتوهای ایکس محدوده ی تشخیصی به وسیله ی کد MCNP
در این پژوهش، به منظور کاهش وزن و افزایش بازده‌ی روپوش‌های محافظتی در تضعیف پرتوهای ایکس محدوده‌ی تشخیصی، استفاده از عناصر تنگستن و باریم در ترکیب با سرب، مورد بررسی قرار گرفت. ابتدا دستگاه پرتو ایکس مستقر در مرکز تحقیقات تابش دانشگاه شیراز با استفاده از کد MCNP4C شبیه‌سازی شد و طیف خروجی پرتوهای ایکس ترمزی و مشخصه‌ی دستگاه به دست آمد. به منظور بررسی صحت شبیه‌سازی انجام شده با کد مونت‌کا...
[ 2 ] - Evaluation of the Possible Utilization of 68Ga-DOTATOC in Diagnosis of Adenocarcinoma Breast Cancer
Objective(s): Studies have indicated advantageous properties of [DOTA-DPhe1 , Tyr3 ] octreotide (DOTATOC) in tumor models and labeling with gallium. Breast cancer is the second leading cause of cancer mortality in women, and most of these cancers are often an adenocarcinoma. Due to the importance of target to non-target ratios in the efficacy of diagnosis, the pharmacokinetic of 68Ga-DOTATOC in...
[ 3 ] - Preclinical Studies of 68Ga-DOTATOC: Biodistribution Assessment in Syrian Rats and Evaluation of Absorbed Dose in Human Organs
Objective(s): Gallium-68 DOTA-DPhe1-Tyr3-Octreotide (68Ga-DOTATOC) has been applied by several European centers for the treatment of a variety of human malignancies. Nevertheless, definitive dosimetric data are yet unavailable. According to the Society of Nuclear Medicine and Molecular Imaging, researchers are investigating the safety and efficacy of this radiotracer to meet Food and Drug Admin...
[ 4 ] - Production, biodistribution assessment and dosimetric evaluation of 177Lu-TTHMP as a bone pain palliation agent
Objective(s): Recently, bone-avid radiopharmaceuticals have been shown to have potential benefits for the treatment of widespread bone metastases. Although 177Lutriethylene tetramine hexa methylene phosphonic acid (abbreviated as 177Lu- TTHMP), as an agent for bone pain palliation, has been evaluated in previous studies, there are large discrepancies between the obtained results. In this study,...
[ 5 ] - Preparation, quality control and biodistribution study of 68Ga-BPAMD: Optimized production with an in-house 68Ge-68Ga generator
Introduction: Bone metastases are common in the progression of various tumors leading to severe pain and decrease in quality of life. The aim of this study was to optimize the production of 68Ga-BPAMD as an ideal bone imaging agent using an in-house 68Ge/68Ga generator for future clinical use. Methods: The optimized condit...
[ 6 ] - Preparation and biodistribution assessment of low specific activity 177Lu-DOTATOC for optimization studies
Introduction: Somatostatin receptors expressed on a wide range of human tumors, are potential targets for the peptide receptor radionuclide therapy (PRRT). In this study, 177Lu-[DOTA-DPhe1, Tyr3]octreotide (177Lu-DOTATOC) as an agent for PRRT was prepared and its biodistribution was studied in rats. Methods:The ...
[ 7 ] - Preclinical studies of 166Ho-chitosan for treatment of hepatocellular carcinoma
Introduction: Recently, due to the special characteristics of 166Ho and chitosan, 166Ho-chitosan complex was developed for treatment of tumors such as hepatocellular carcinoma. This complex has been lately prepared with high radiochemical purity in our lab. The preclinical studies of the complex however should be performed to evaluate the tracer concentration in target and...
[ 8 ] - Human organ absorbed dose estimation of 166Ho-BPAMD complex based on biodistribution data of male Syrian rats
Introduction: Recently, 166Ho-BPAMD was introduced as a suitable agent for bone marrow ablation. The aim of this study was to estimate the absorbed dose of this novel agent in the human organs which is necessary before the clinical application. Methods: 166Ho was produced by direct irradiation of 165Ho in the research reactor. 250 µg...
[ 9 ] - Biological assessment and human absorbed dose estimation of [111In]In-DTPA-antiMUC1 as a radioimmunoconjugate for breast cancer imaging
Introduction: The aim of this study was to evaluate the human organ absorbed dose of [111In]In-DTPA-antiMUC1, as a newly developed radioimmunoconjugate. Methods: [111In]In-DTPA-antiMUC1 was prepared at optimized conditions while the radiochemical purity of the tracer was investigated using ITLC method. Biodistribution of the radiolab...
نویسندگان همکار