Tomoki Nishiyama

Maruyama Memorial General Hospital

[ 1 ] - Spinally mediated analgesic interaction between γ-aminobutyric acid B receptor agonist and glutamate receptor antagonists in rats

Background. Many mechanisms are involved in pain transmission in the spinal cord. Therefore, combination of drugs acting on different kinds of mechanisms might be useful for analgesia. We investigated the interaction betweenγ-aminobutyric acid （GABA）B receptor agonist, baclofen, and N-methyl-D-aspartate （NMDA） receptor antagonist, AP-5, orα-amino-3-hydroxy-5-methylisoxazole-4-propionic acid ...

[ 2 ] - Anesthesia for leg amputation in high risk patients: Case reports

Background: High risk cases of leg amputation were one of major concerns in anesthesiologists.　 Cases: Sixteen cases with American Society of Anesthesiologists physical status (ASA-PS) 3 or 4 for leg amputation were reported. Fifteen patients were medicated with more than two anticoagulants and 11 patients had bleeding tendency. Thirteen patients received below knee amputation (BKA) and thre...

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