Solimani, Poriea

[ 1 ] - The effects of chronic administration of pioglitazone on learning and memory in streptoztocin rat model of Alzheimer’s disease

Background: Alzheimer’s disease (AD) is a chronic neurodegenerative disease characterized by abnormal protein accumulation, synaptic dysfunction, and cognitive impairment. Peroxisome proliferator-activated gamma receptors (PPARγ) play a crucial role in regulating insulin sensitivity and may serve as potential therapeutic targets for AD. Pioglitazone (Piog) as a PPARγ   agonist reduce β-amyloid ...