Fatemi R

[ 1 ] - P-212: Association between Polymorphisms of CTLA-4 Gene and Unexplained Recurrent Spontaneous Abortion in An Iranian Population

Background: Unexplained recurrent spontaneous abortion (URSA) has been suggested being associated with the failure of fetal-maternal immunologic tolerance in which the regulatory T lymphocytes (Tregs) play a crucial role. Cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) is expressed transiently on activated T cells and constitutively on Tregs. CTLA-4 interacts with the B7 cell surface molec...

[ 2 ] - P-154: Comparison between The Effect of 17-Bestradiol at Preovulatory and Pregnancy Levels for In Vitro Generation of Regulatory T Cells

Background: Naturally occurring CD4+CD25+ regulatory T cells (Treg) exert an important role in mediating maternal tolerance to the fetus during pregnancy. During pregnancy the elevated number of regulatory T cells (Tregs) correlates with 17-b oestradiol (E2) level. The role of maternal hormones in successful pregnancy is well known. Maternal hormones through re-engineering of the maternal immun...

[ 3 ] - P-210: Estrogen Receptor Beta Gene Polymorphisms and Recurrent Pregnancy Loss: A Case- Control Study in A Population of Iranian Women

Background: Recurrent pregnancy loss (RPL), that affects 1-5% of couples, is a multifactorial disorder as both genetic and environmental factors are involved. The aim of this study was to determine association of single nucleotide polymorphisms (SNPs) located on estrogen receptor beta (ERβ) gene with the risk of RPL in a population of Iranian women; +1082G>A (rs1256049) in exon 5, +1730G>A (rs4...