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[ 1 ] - P-57: Simvastatin Abates Doxorubicin-Induced Teratozoospermia

Background: Therapeutic utilities of doxorubicin (DOX), an anticancer anthracycline antibiotic, are limited by its serious dosedependent toxicity to non-target tissues such as testis. The aim of the present study was to elucidate the potential of simvastatin (SIM), a lipid lowering agent with antioxidant and anti-inflammatory activities, to attenuate DOX-induced spermatotoxicity in male mice. M...

[ 2 ] - P-145: Efficacy of Simvasiatin in The Prevention of Doxorubicin-Induced Testicular Morphometric-Stereological Alterations in Mice

Background: Doxorubicin (DOX), a widely used antineoplastic compound, is associated with testicular damage and infertility. In this study, we intended to determine the possible preventive effects of simvastatin (SIM), a lipid lowering agent with antioxidant and anti-inflammatory activities, on testicular morphometric-stereological changes due to DOX treatment in mice. Materials and Methods: Mal...

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