A Ruzov

[ 1 ] - O-5: Reprogramming of Paternal DNA Methylome during Spermiogenesis

Background Chromatin of male and female gametes undergoes a number of reprogramming events during the transition from germ cell to embryonic developmental programs in the zygote. This process involves reorganisation of the patterns of 5-methylcytosine (5mC), a DNA modification associated with regulation of gene activity. Notably, both maternal and paternal genomes undergo Tet3-dependent oxidati...