Shafia, Sakineh
Assistant Professor, Department of Physiology, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran
[ 1 ] - Effects of Moderate Treadmill Exercise and Fluoxetine on Spatial Memory and Serum BDNF Levels in an Animal Model of Post-traumatic Stress Disorder
Background and purpose: Post-traumatic stress disorder (PTSD) develops after major trauma that is accompanied by certain signs, including pervasive fear memories, anxiety, abnormality in spatial and cognition memory, and decrease in hippocampal brain-derived neurotrophic factor (BDNF). Selective serotonin reuptake inhibitors (SSRIs) are the first-line treatment for PTSD. This study aimed at inv...
[ 2 ] - Effects of Moderate Treadmill Exercise and Fluoxetine on Spatial Memory, Anxiety, and Positive Tunnel Cells in the Hippocampus in a Rat Model of PTSD
Background and purpose: Post-traumatic stress disorder (PTSD) is a condition that develops after experiencing major trauma. Selective serotonin reuptake inhibitors (SSRIs) are first-line treatment for PTSD. This study aimed at investigating the effects of moderate treadmill exercise and fluoxetine on anxiety, spatial memory, and positive tunnel cells in the hippocampus in a rat model of PTSD. ...
[ 3 ] - Effects of Moderate Treadmill Exercise on Anxiety and Serum Corticosterone and IGF-1 Levels in A Rat Model of Post-Traumatic Stress Disorder
Background and purpose: Post-traumatic stress disorder (PTSD (is a psychotic illness caused by different types of stressors and is associated with high economic and psychological burdens on health systems. Physiological studies of the brain have shown that serum corticosterone and insulin-like growth factor 1 (IGF-1) levels have important roles during brain damage and trauma to the nervous syst...
[ 4 ] - Cognitive Function and Hippocampal Glutathione and Malondialdehyde Levels in Paraoxon-intoxicated Rats
Background and purpose: Exposure to organophosphorus (OP) compounds may contribute to an increased risk of cognitive impairments and induction of oxidative stress. The present study was designed to evaluate the effects of exposure to paraoxon (the active metabolite of insecticide parathion) on cognitive function and oxidative stress biomarkers. Materials and methods: Adult male Wistar rats (n=...
[ 5 ] - Comparing the Effect of Treadmill Exercise and Fluoxetine on Sex Hormones, Testicular Histopathology, and Fear Extinction in Adult Wistar Rats with Post-Traumatic Stress Disorder
Background and purpose: Post-traumatic stress disorder (PTSD) is a mental and physical complication. Fluoxetine (FLX) as a selective serotonin reuptake inhibitor is considered as the first line of treatment for PTSD. Exercise can improve the symptoms of PTSD. The aim of this study was to determine the effects of exercise and FLX on testicular tissue and sex hormones in rats with PTSD. Materia...
[ 6 ] - Responsiveness to the Effect of Fluoxetine in Male and Female Rats Exposed to Single Prolonged Stress: A Behavioral, Biochemical, Molecular and Histological Study
Background: Selective serotonin reuptake inhibitors (SSRIs) like fluoxetine are the first-line choice in patients with PTSD. Animal studies have indicated that chronic fluoxetine exposure leads to persistent behavioral changes and neuroplasticity in the hippocampal formation and cortex. Previous studies revealed that adult female rats respond differently to trauma from adult males. Here, we hav...
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