Seyed Ali Nojoumi
Microbiology Research Center, Pasteur Institute of Iran, Tehran, Iran.
[ 1 ] - Computational Approach for Rational Design of Fusion Uricase with PAS Sequences
Tumor lysis syndrome is a life-threatening condition for humans due to the lack of urate oxidase. In this study, several variants of PASylateduricasefrom the Aspergillus flavus species were analyzed computationally to find the appropriate fusions to solve short half-life and stability concerns. The Ab initio method was performed using Rosetta software to structurally characterize the PAS sequen...
[ 2 ] - Interaction between Intestinal Microbiota and Serotonin Metabolism
Gut microbiota regulates the production of signaling molecules, such as serotonin or 5-Hydroxytryptamine: 5-HT in the host. Serotonin is a biogenic amine that acts as a neurotransmitter in the gut and brain. There is a perfect interaction between human gastrointestinal microbiota and the serotonin system. The gut microbiota plays an important role in the serotonin signaling pathways through the...
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