Saeed Ghasemi
Department of Medicinal Chemistry, School of Pharmacy, Guilan University of Medical Sciences, Rasht, Iran.
[ 1 ] - Evaluation of Antioxidant, Antibacterial and Cytotoxic Activity of Methanol Extract from Leaves and Fruits of Iranian Squirting Cucumber (Ecballium elaterium (L.) A. Rich)
Background and objectives: Ecballium elaterium (L.) A. Rich (squirting cucumber) has been used traditionally as a remedy for different disorders such as fever, sinusitis, and rheumatic disease. In the present study, antibacterial, antioxidant, and cytotoxic activities of leaves and fruits were evaluated. Also, total flavonoid and phenolic contents were measured were me...
[ 2 ] - 2D-QSAR and docking studies of 4-anilinoquinazoline derivatives as epidermal growth factor receptor tyrosine kinase inhibitors
Introduction: Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor derivatives play an important role in the treatment of cancer. We aim to construct 2D-QSAR models using various chemometrics using 4-anilinoquinazoline-containing EGFR TKIs. In addition, the binding profile of these compounds was evaluated using a docking study. Materials and Methods: In this study, 122 compounds of...
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