Nasrollahi, Saeedeh
Student Research Center, Kashan University of Medical Sciences, Kashan, I.R. Iran.
[ 1 ] - The effect of chronic caffeine administration on hyperalgesia in a rat neuropathic pain model: role of nitric oxide pathway
Background: Neuropathic pain is a chronic pain caused by damage to the central nervous system and the peripheral. Caffeine is a non-selective antagonist of A1, A2a, receptors of adenosine, which has a protective effect on neuropathic pain in some doses by inhibiting A2a, A2b receptors. Considering that the nitric oxide (NO) levels are apparently effective in the parts of caffeine central effect...
[ 2 ] - Evaluation of the effect of orexin-1 receptors in the nucleus accumbens shell on cost-benefit decision making in male rats
Background: Cost-benefit decision-making is a one of the decision-making models in which the animal achieves a final benefit (reward) by evaluating the cost (effort or delay). The role of different brain regions such as nucleus accumbens in this process has been proven. Orexin is a neuropeptide expressed exclusively by lateral hypothalamus area neurons and orexin-producing neurons project their...
[ 3 ] - Effect of acute caffeine administration on hyperalgesia and allodynia in a rat neuropathic pain model
Introduction: Damage to the central and peripheral nervous system causes neuropathic pain. Caffeine is a plant alkaloid and non-selective antagonist of A1, A2a and A2b adenosine receptors. It is reported that caffeine increases the threshold of pain. In this study, the effect of acute caffeine on behavioral responses of neuropathic pain was investigated. Materials and Methods: The present study...
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