پاشایی, مهرنوش
. مرکز تحقیقات سرطان، دانشگاه علوم پزشکی سمنان، سمنان، ایران 2. دکترای ایمونولوژی، گروه ایمنی شناسی، دانشکده پزشکی، دانشگاه علوم پزشکی تهران، تهران، ایران
[ 1 ] - اثر بربرین بر بیان ژن Bcl-2 در بیماران لوسمی لنفوسیتی مزمن در مقایسه با گروه کنترل
Background and purpose: Anti-apoptotic protein Bcl-2 prevents apoptosis through the mitochondrial pathway and high-level expression of Bcl-2 is required for survival of chronic lymphocytic leukemia (CLL). Berberine (BBR) is an alkaloid that induces apoptosis of cancer cells via mitochondrial pathways. The aim of this study was to investigate the effect of Berberine on Bcl-2 gene expression in p...
[ 2 ] - Effect of IL-27 on activity of bone marrow NK cells of patient with B-chronic lymphocytic leukemia in vitro
Introduction: Functional defect in immune cells is the prominent feature in hematological malignancies that lead to the expansion of tumor cells. Using immunostimulatory cytokines is one of the new therapeutic approaches. This study aimed to investigate the effect of IL-27 on the activity of bone marrow-NK cells of chronic lymphocytic leukemia (CLL) patients in vitro. Materials and Methods: 10 ...
[ 3 ] - Review on Interferon beta: from cells to clinical usage
Introduction: Interferon (IFN) was first introduced by Isaacs and Linddeman in 1957. It referred to a factor that could cause inhibition in the growth of the live influenza virus. Interferons are intracellular proteins that are involved in many cellular processes such as growth, proliferation, differentiation, metabolism of the extracellular matrix, apoptosis, and regulating immune responses. T...
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