Soghra Khabnadideh

[ 1 ] - Antibacterial Activity of Some New Azole Compounds

[ 2 ] - Antigiardiais Effects of New Metronidazole Derivatives on Trophozoites in TYI-S-33

      Giardia is a flagellate protozoan with worldwide distribution that causes significant gastrointestinal diseases. The life cycle of the organism alternates between the active, proliferating trophozoite and the dormant cyst. 5-Nitroimida-zoles have been used extensively in the treatment of amoebiasis, giardiasis, and trichomoniasis. We have previously synthesized ...

[ 3 ] - Solubility of Cyproterone Derivatives in the Presence of Hydroxypropyl-β-Cyclodextrin: Experimental and Molecular Modeling Studies

      This study presents the influence of hydroxypropyl-β-cyclodextrin (HPBCD) on the aqueous solubility of acyl esters of cyproterone. First, a number of esters of cyproterone were synthesized. Then the phase solubility analysis of the compounds in the presence of HPBCD was investigated in phosphate buffer solution at a pH of 7.4. To gain a better understanding of the complexation mechanism, ...

[ 4 ] - Post Marketing Surveillance on Propranolol and Atenolol Tablets Manufactured in Iran

       Propranolol, a prototypical b-adrenergic receptor antagonist and atenolol, a cardio-selective b-antagonist are widely used in therapeutic regimens for treatment of hypertensive patients. In Iran, several pharmaceutical manufacturers formulate these two b-blockers. As the formulation of a dosage form is essential for the patient's safety and drug efficacy, in this study we aimed to evalu...

[ 5 ] - Design and Synthesis of 2-Methyl and 2-Methyl-4-Nitro Imidazole Derivatives as Antifungal Agents

      Two series (a and b) of N- substituted heteroaromatic compounds related to clotrimazole were synthesized. Imidazole ring of the clotrimazole was replaced by 2-methylimidazole in series a, and by 2-methyl-4-nitroimidazole in series b. O-cholortrityl moiety of clotrimazole was also replaced by trityl, mono or dimethoxy trityl. Chemical structures...