Jitendra Banweer

[ 1 ] - Development and Optimization of Transdermal System of Lisinopril dehydrate: Employing Permeation Enhancers

      Lisinopril dihydrate (angiotensin converting enzyme inhibitor) is a lysine derivative of enalaprilat and does not require hydrolysis to exert pharmacological activity. It has an extensive hepatic first pass metabolism resulting in a bioavailabil-ity of 6-60%. To overcome the poor bioavailability of the drug, transdermal patches have been prepared. The present study also aims at optimizati...