Ali Pourmotabbed
Dept. of Physiology, School of Medicine, Kermanshah University of Medical Sciences
[ 1 ] - The effect of Crocin on scopolamine induced spatial learning and memory deficits in rats
Introduction: The cholinergic system plays an important role in learning and memory. Administration of either extracts of Crocus Sativus (Saffron) or its constituent, crocin, reduced ethanol-induced memory impairment. Based on the above findings, we investigated the effect of crocin in antagonizing spatial learning and memory impairment induced by scopolamine, a cholinergic receptor antagoni...
[ 2 ] - The effect of morphine dependence on expression of hippocampal N-methyl-D-aspartate receptor subunits in male rats
Introduction: N-methyl-D-aspartate (NMDA) receptors play a pivotal role in the development of tolerance and physical dependence to opiates. Activation of NMDA receptors involves the induction of long term potentiation (LTP) in hippocampus. Our previous study suggested that chronic oral administration of morphine enhanced NMDA dependent LTP in the CA1 area of hippocampal slices of rats. The p...
[ 3 ] - Assessment of the effect of nitric oxide within hippocampal CA1 area on spatial learning and memory in morphine dependent rats
Introduction: There are evidences showing the role of nitric oxide in the opiate reward properties. The role of nitric oxide signaling pathway as an intracellular mechanism on augmentation of long term potentiation in hippocampal CA1 area of rats is also confirmed. It has been also reported that oral morphine dependence facilitates formation of spatial learning and memory via activation of N...
[ 4 ] - Assessment of the role of NMDA receptors located in hippocampal CA1 area on the effects of oral morphine dependency on spatial learning and memory in rat
Introduction: It has been reported that oral morphine dependency facilitated formation of spatial learning and memory. In the present study the role of NMDA receptors located in hippocampal CA1 area of morphine dependent rats was studied. Methods: Male rats were divided into 4 groups. Two cannulae were stereotaxically implanted bilaterally into the hippocampal CA1 area. After 5 days recover...
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