Elias Adikwu
Department of Pharmacology, Faculty of Basic Medical Sciences, University of Port Harcourt, Choba, Rivers State, Nigeria
[ 1 ] - Melatonin and alpha lipoic acid as possible therapies for lopinavir/ritonavir-induced hepatotoxicity in albino rats
Introduction: The use of lopinavir/ritonavir (LPV/r) has decreased morbidity and mortality due to human immunodeficiency virus (HIV); however its use could be impaired by hepatotoxicity. Therefore, this study was designed to investigate the effects of melatonin (MT) and alpha lipoic acid (ALA) on LPV/r-induced hepatotoxicity in male albino rats. Methods: Rats were divided into groups and treate...
[ 2 ] - Melatonin and Alpha Lipoic Acid: Possible Mitigants for Lopinavir/Ritonavir- Induced Renal Toxicity in Male Albino Rats
Introduction: This study evaluated the effects of pretreatments with melatonin (MT), and Alpha Lipoic acid (ALA) on lopinavir/ritonavir (LPV/r) -induced serum levels of creatinine (Cr), urea (U), uric acid (Ua) and kidney levels of malondialdehyde (MDA), superoxide dismutase (SOD), glutathione (GSH) and catalase (CAT) in male albino rats. Effects of treatments with MT and ALA were also evaluate...
[ 3 ] - Selenium safeguards the liver against 5flurouracil-induced toxicity
Hepatotoxic effect of 5-Fluourouracil (5-FU) can deprive cancer patients of maximum therapeutic benefits. Aim: This study assessed the ability of selenium (Se) to protect against hepatotoxicity induced by 5-FU in rats. Forty adult albino rats were groups and used. Rats in group A (control) were treated intraperitoneally (ip) with 0.2ml of normal saline daily for 5 days. Rats in groups B1-B3 wer...
[ 4 ] - Protective Effect of Time-Modulated Cimetidine on Methotrexate-induced Liver Toxicity
Background: Methotrexate (MTX) is one of the frequently used chemotherapeutic agents, especially in hematological malignancies and solid tumors. Objectives: MTX hepatotoxicity symptoms range from elevations in serum aminotransferases to hepatocyte necrosis and fibrosis. The time of medication administration significantly impacts treatment outcomes. Hence this study evaluated the protective eff...
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