Sorour Shojaeian
Department of Clinical Biochemistry, Medical Genetics, Nutrition, Alborz University of Medical Sciences, Karaj, Iran
[ 1 ] - Single administrations of high and low doses of acetaminophen causes different effects on COX-2 gene expression and on tissue damage in liver and kidneys
Introduction: High dose of acetaminophen (APAP) is known to have hepatotoxic and nephrotoxic effects and studies show that this toxicities are dependent on the function of phase I bioactivation enzymes- Cyp450- and phase II biotransformation enzymes especially glucuronosylation and sulfonation pathways. However, the role of cyclooxygenase (COX) as an inflammatory mediator in toxic effects of AP...
نویسندگان همکار